Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
MCF 10A
NM
Basal B
 Gefitinib
EGFR
ErbB
7867.016
uM
0.67463
0.83770
 -0.4905 -0.3312 2.3474 0.3641
0.9804
 2.2657
MCF 10A
NM
Basal B
 Geldanamycin
HSP90
HSP90
9551.012
uM
0.00696
0.00763
 -0.3517 -0.2925 5.0000 0.9286
0.9964
 2.7057
MCF 10A
NM
Basal B
 Geldanamycin
HSP90
HSP90
7867.04
uM
0.00537
0.00675
 -0.4350 -0.4003 2.5605 1.0387
0.9983
 2.4460
MCF 10A
NM
Basal B
 Geldanamycin
HSP90
HSP90
7870.012
uM
0.00680
0.00806
 -0.2834 -0.2754 2.5891 0.9316
0.9997
 2.3112
MCF 10A
NM
Basal B
 Gemcitabine
DNA replication
DNA replication
7867.011
uM
0.03370
0.04296
 -0.1230 -0.0832 0.6337 0.6639
0.9530
 2.3684
MCF 10A
NM
Basal B
 Gemcitabine
DNA replication
DNA replication
9551.011
uM
0.05977
0.04969
 0.0427 0.0559 0.6424 0.5718
0.9564
 2.7742
MCF 10A
NM
Basal B
 Gemcitabine
DNA replication
DNA replication
7870.011
uM
0.03926
0.07694
 -0.1964 -0.2068 0.5144 0.6901
0.9658
 2.1270
MCF 10A
NM
Basal B
 Glycyl-H-1152
ROCK2
11056.15
uM
inf
2.34330
 0.5757 0.5710 2.1336 0.0938
0.9859
 3.0207
MCF 10A
NM
Basal B
 GM6001
MMP
MMP
7485.096
uM
inf
inf
 0.9280 0.9280 0.0000 0.0372
0.4223
 3.6265
MCF 10A
NM
Basal B
 GSK1070916
AURK
AURK
9551.001
uM
1.7540
36.29570
 -0.0203 -1.0000 0.3626 0.2778
0.9514
 2.6913
MCF 10A
NM
Basal B
 GSK1070916
AURK
AURK
7870.001
uM
1.96320
10.9960
 -0.4454 -1.0000 0.6376 0.2925
0.9560
 2.0700
MCF 10A
NM
Basal B
 GSK1838705A
IGF1R
RTK
7483.071
uM
11.22290
4.02960
 0.2279 0.3500 1.1754 0.1989
0.8634
 3.5590
MCF 10A
NM
Basal B
 GSK1838705A
IGF1R
RTK
7484.09
uM
inf
0.39993
 0.5550 0.5919 1.0858 0.1983
0.9279
 2.6525
MCF 10A
NM
Basal B
 GSK1838705A
IGF1R
RTK
7483.091
uM
5.84960
6.37170
 -0.4695 -0.2667 5.0000 0.3192
0.9527
 3.0465
MCF 10A
NM
Basal B
 GSK1838705A
IGF1R
RTK
7483.098
uM
inf
1.18680
 0.6417 0.6509 1.1161 0.1112
0.9837
 3.1224
MCF 10A
NM
Basal B
 GSK1838705A
IGF1R
RTK
7485.098
uM
1.00030
2.9910
 -0.4745 -0.6398 0.7523 0.4067
0.9921
 3.3725
MCF 10A
NM
Basal B
 GSK1838705A
IGF1R
RTK
7484.098
uM
5.08830
17.60130
 -0.5501 -1.0000 0.8853 0.2731
0.9940
 2.6137
MCF 10A
NM
Basal B
 GSK1838705A
IGF1R
RTK
7485.092
uM
1.89580
4.83330
 -0.2772 -0.4760 0.7146 0.3201
0.9954
 3.6408
MCF 10A
NM
Basal B
 GSK1838705A
IGF1R
RTK
7484.07
uM
4.1850
5.73620
 -0.5360 -0.5440 2.3350 0.3014
0.9954
 2.4739
MCF 10A
NM
Basal B
 GSK461364
PLK1
PLK
7870.001
uM
0.04308
0.04394
 -0.5473 -0.0517 4.9976 0.5236
0.8583
 2.0700
MCF 10A
NM
Basal B
 GSK461364
PLK1
PLK
9551.001
uM
0.04916
0.05138
 -0.1588 -0.1234 4.9999 0.5825
0.9782
 2.6913
MCF 10A
NM
Basal B
 GSK923295
CENPE
Kinesin
7870.001
uM
0.45656
5.52670
 -0.1697 -0.6438 0.3318 0.3706
0.8743
 2.0700
MCF 10A
NM
Basal B
 GSK923295
CENPE
Kinesin
9551.001
uM
0.05519
0.04299
 0.3271 0.3567 4.9990 0.3437
0.980
 2.6913
MCF 10A
NM
Basal B
 GW-5074
CRAF
MAPK
7485.088
uM
37.34470
38.63010
 0.6475 -0.0920 4.9918 0.0294
0.9488
 3.6725
MCF 10A
NM
Basal B
 Ibandronate
FDPS
11056.143
uM
513.60230
657.23440
 -0.0072 -0.2578 1.6861 0.0771
0.9915
 2.8628