Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LY2 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 9536.011 | uM | 0.03769 | 0.01732 | 0.4261 | 0.4619 | 3.3111 | 0.3847 | 0.9569 | 1.2640 | |
| LY2 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 10264.011 | uM | 0.01515 | 0.00980 | 0.4029 | 0.4434 | 5.0000 | 0.4053 | 0.9814 | 1.3983 | |
| LY2 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 12319.169 | uM | 0.10975 | 2.69160 | -0.4744 | -1.0000 | 0.3434 | 0.6374 | 0.8878 | 0.9948 | ||
| LY2 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 10816.15 | uM | 1.03120 | 1.75740 | -0.9598 | -0.9331 | 1.9753 | 0.3994 | 0.9955 | 0.3031 | ||
| LY2 | HR+ | Luminal | GSK1070916 | AURK | AURK | 10264.001 | uM | 9.11390 | 14.85550 | -0.7214 | -0.9999 | 2.2485 | 0.1714 | 0.9881 | 1.5356 | |
| LY2 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 7477.098 | uM | 2.130 | 2.42270 | -0.7323 | -0.4519 | 5.0000 | 0.5164 | 0.8510 | 1.4247 | |
| LY2 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 7477.091 | uM | 0.67592 | 1.69210 | -0.9946 | -1.0000 | 1.1972 | 0.6859 | 0.9762 | 1.1485 | |
| LY2 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 7477.071 | uM | 0.62597 | 1.35510 | -1.0000 | -0.9841 | 1.4086 | 0.6625 | 0.9893 | 0.5122 | |
| LY2 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 10380.092 | uM | 0.46366 | 0.42214 | 0.1747 | 0.1872 | 5.0000 | 0.3130 | 0.9930 | 1.4888 | |
| LY2 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 10264.001 | uM | 1.5220 | 12.28790 | -0.5051 | -1.0000 | 0.5260 | 0.3393 | 0.7954 | 1.5356 | |
| LY2 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 10264.001 | uM | 2.16170 | 56.86920 | -0.0483 | -1.0000 | 0.3360 | 0.2627 | 0.8398 | 1.5356 | |
| LY2 | HR+ | Luminal | Ibandronate | FDPS | 12319.143 | uM | 54.84830 | 90.60060 | -0.9785 | -0.9712 | 2.1503 | 0.5591 | 0.8637 | 0.5178 | ||
| LY2 | HR+ | Luminal | Ibandronate | FDPS | 10816.143 | uM | 120.21070 | 144.11240 | -0.7303 | -0.7380 | 4.9993 | 0.2822 | 0.9954 | 0.4975 | ||
| LY2 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 12319.157 | uM | 1.06990 | 5.52430 | 0.1972 | -0.3028 | 0.2884 | 0.3663 | 0.7639 | 1.0058 | |
| LY2 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 10816.151 | uM | inf | 0.3770 | 0.6390 | 0.6502 | 5.0000 | 0.0869 | 0.9395 | 0.9672 | |
| LY2 | HR+ | Luminal | IKK16 | IKK | NFKB | 10380.093 | uM | 4.96840 | 6.12220 | -0.9112 | -0.9204 | 5.0000 | 0.3282 | 0.9978 | 1.4880 | |
| LY2 | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 10380.092 | uM | 22.08650 | 30.64770 | -0.9366 | -0.9292 | 3.2060 | 0.4107 | 0.9976 | 1.4888 | |
| LY2 | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 7477.091 | uM | 22.92130 | 28.53740 | -0.9946 | -0.9956 | 4.9997 | 0.4021 | 0.9980 | 1.1485 | |
| LY2 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 7477.067 | uM | 0.02797 | 0.03324 | -0.9999 | -0.6861 | 5.0000 | 0.8886 | 0.9769 | 0.6787 | |
| LY2 | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 10380.095 | uM | 0.00555 | 0.00888 | -0.9425 | -0.5797 | 1.6393 | 0.9929 | 0.9335 | 1.4726 | |
| LY2 | HR+ | Luminal | JNK-IN-5A | JNK | JNK | 10816.144 | uM | 1.95210 | 2.04450 | -0.5137 | -0.1287 | 4.9543 | 0.3671 | 0.7409 | 0.9146 | |
| LY2 | HR+ | Luminal | JNK-IN-5A | JNK | JNK | 12319.168 | uM | 0.51624 | 0.69972 | -0.6500 | -0.6240 | 2.6635 | 0.7125 | 0.9962 | 0.9560 | |
| LY2 | HR+ | Luminal | L-779450 | BRAF | MAPK | 12319.166 | uM | inf | inf | 0.6126 | 0.6126 | 0.0000 | 0.2273 | 0.0745 | 1.3789 | |
| LY2 | HR+ | Luminal | L-779450 | BRAF | MAPK | 10816.149 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.4545 | |
| LY2 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 7477.098 | uM | inf | inf | 0.7778 | 0.7778 | 0.0000 | 0.0908 | -0.0575 | 1.4247 |