Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | TNBC | Basal B | Epirubicin | TOP2 | TOP | 7861.017 | uM | 0.25036 | 0.80531 | -0.9757 | -0.8847 | 0.8718 | 0.7806 | 0.9887 | 1.8068 | |
| Hs 578T | TNBC | Basal B | Erlotinib | EGFR | ErbB | 7472.092 | uM | inf | inf | 1.0174 | 1.0174 | 0.0000 | -0.0459 | -20.4790 | 1.2676 | |
| Hs 578T | TNBC | Basal B | Erlotinib | EGFR | ErbB | 7474.09 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0177 | -0.3118 | 2.4405 | |
| Hs 578T | TNBC | Basal B | Erlotinib | EGFR | ErbB | 7471.092 | uM | inf | inf | -0.3277 | -0.3277 | 0.0000 | 0.7586 | -0.0557 | 0.3860 | |
| Hs 578T | TNBC | Basal B | Erlotinib | EGFR | ErbB | 10379.092 | uM | 90.50410 | 757.49670 | 0.6506 | -1.0000 | 0.5171 | 0.0829 | 0.7673 | 2.5811 | |
| Hs 578T | TNBC | Basal B | Erlotinib | EGFR | ErbB | 7473.091 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 2.3297 | |
| Hs 578T | TNBC | Basal B | Erlotinib | EGFR | ErbB | 7475.091 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 2.6839 | |
| Hs 578T | TNBC | Basal B | Etoposide | TOP2 | TOP | 7475.074 | uM | 6.17310 | 10.49360 | -0.7940 | -0.6193 | 1.5188 | 0.3945 | 0.9715 | 2.4793 | |
| Hs 578T | TNBC | Basal B | Etoposide | TOP2 | TOP | 7472.074 | uM | 11.96570 | 14.17630 | -0.6937 | -0.6671 | 5.0000 | 0.3973 | 0.9945 | 1.5922 | |
| Hs 578T | TNBC | Basal B | Etoposide | TOP2 | TOP | 7474.074 | uM | 6.21020 | 8.89680 | -0.6288 | -0.5755 | 2.1305 | 0.4129 | 0.9955 | 2.6218 | |
| Hs 578T | TNBC | Basal B | Etoposide | TOP2 | TOP | 7473.074 | uM | 7.38250 | 9.0670 | -0.4978 | -0.4637 | 3.1924 | 0.3952 | 0.9970 | 2.5364 | |
| Hs 578T | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 7473.084 | uM | 0.95755 | 1.15660 | -0.9410 | -0.7856 | 4.9994 | 0.4445 | 0.9889 | 2.0337 | |
| Hs 578T | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 7474.084 | uM | 0.83282 | 1.00080 | -0.8699 | -0.7532 | 5.0000 | 0.4995 | 0.9908 | 2.6631 | |
| Hs 578T | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 7475.084 | uM | 0.86639 | 1.04980 | -0.8415 | -0.8056 | 4.9999 | 0.4773 | 0.9973 | 2.7804 | |
| Hs 578T | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 10694.149 | uM | inf | inf | 0.9542 | 0.9542 | 0.0000 | 0.0010 | 0.4579 | 2.3563 | |
| Hs 578T | TNBC | Basal B | FTase Inhibitor I | Ftase | MAPK | 10694.154 | uM | inf | inf | 0.9764 | 0.9764 | 0.0000 | -0.0084 | -0.0364 | 2.3045 | |
| Hs 578T | TNBC | Basal B | Gefitinib | EGFR | ErbB | 7864.016 | uM | 34.76760 | 37.50720 | 0.5230 | -0.0824 | 2.0104 | 0.0610 | 0.8868 | 1.4893 | |
| Hs 578T | TNBC | Basal B | Gefitinib | EGFR | ErbB | 7861.016 | uM | 9.68140 | 16.81060 | -0.5950 | -1.0000 | 1.9909 | 0.2241 | 0.9544 | 2.0473 | |
| Hs 578T | TNBC | Basal B | Gefitinib | EGFR | ErbB | 7862.016 | uM | 26.62450 | 28.66980 | 0.3047 | -0.1303 | 3.1298 | 0.0522 | 0.9551 | 1.3229 | |
| Hs 578T | TNBC | Basal B | Gefitinib | EGFR | ErbB | 7863.016 | uM | 24.11230 | 39.92670 | 0.2219 | -0.9065 | 2.0508 | 0.0723 | 0.9834 | 1.7699 | |
| Hs 578T | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 9511.012 | uM | 0.02880 | 0.05161 | -0.5604 | -0.4151 | 1.0360 | 0.8079 | 0.9749 | 1.2568 | |
| Hs 578T | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 7862.04 | uM | 0.08575 | 0.11793 | -0.5151 | -0.4589 | 2.0433 | 0.7824 | 0.9896 | 1.4556 | |
| Hs 578T | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 7864.011 | uM | 1.67230 | 1.46940 | 0.1733 | 0.2381 | 5.0000 | 0.2906 | 0.9134 | 1.4831 | |
| Hs 578T | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 7862.011 | uM | 0.06272 | 0.05076 | 0.0913 | 0.1315 | 1.4424 | 0.5464 | 0.9506 | 1.3695 | |
| Hs 578T | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 7863.011 | uM | 5.23790 | 4.73310 | 0.0692 | 0.0626 | 1.3206 | 0.2615 | 0.9938 | 2.0237 |