Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LY2 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9536.017 | uM | 10.58090 | 19.62810 | -0.9093 | -0.9422 | 1.7144 | 0.4000 | 0.9978 | 1.4526 | |
| LY2 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 10264.121 | uM | 13.98020 | 36.9810 | -0.4963 | -1.0000 | 1.1294 | 0.2307 | 0.9667 | 1.3643 | |
| LY2 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 12319.155 | uM | inf | inf | 0.9243 | 0.9243 | 0.0000 | 0.2716 | 0.2645 | 0.9333 | |
| LY2 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 10816.155 | uM | 0.14517 | 0.24916 | -0.8172 | -0.7752 | 1.7334 | 0.6687 | 0.9970 | 0.8353 | |
| LY2 | HR+ | Luminal | Dichloroacetate | PDK | PDK | 12627.176 | uM | inf | 0.57139 | 0.9425 | 0.9399 | 1.6582 | 0.0008 | 0.6060 | 1.2157 | |
| LY2 | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 12627.174 | uM | 4.71770 | 8.06620 | -0.9429 | -0.9781 | 2.0208 | 0.4654 | 0.8456 | 1.3419 | |
| LY2 | HR+ | Luminal | Docetaxel | TUBB | TUBB | 10264.002 | uM | 0.00945 | 0.00756 | 0.1452 | 0.1345 | 1.4084 | 0.4669 | 0.9869 | 1.2356 | |
| LY2 | HR+ | Luminal | Docetaxel | TUBB | TUBB | 9536.002 | uM | 0.00418 | 0.00548 | -0.2397 | -0.2457 | 1.4695 | 0.7191 | 0.9989 | 1.3627 | |
| LY2 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 10264.121 | uM | 0.19334 | 0.23702 | -0.8571 | -0.3147 | 2.3968 | 0.5984 | 0.8617 | 1.3643 | |
| LY2 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 7865.017 | uM | 0.24347 | 5.35440 | -0.9199 | -1.0000 | 0.3555 | 0.6601 | 0.8352 | 1.9138 | |
| LY2 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 9536.017 | uM | 0.30234 | 0.34796 | -0.9612 | -0.5096 | 5.0000 | 0.6777 | 0.9311 | 1.4526 | |
| LY2 | HR+ | Luminal | Erlotinib | EGFR | ErbB | 7477.091 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0458 | -19.0433 | 1.1485 | |
| LY2 | HR+ | Luminal | Erlotinib | EGFR | ErbB | 10380.092 | uM | inf | inf | 0.9525 | 0.9525 | 0.0000 | -0.0404 | -1.1056 | 1.4888 | |
| LY2 | HR+ | Luminal | Etoposide | TOP2 | TOP | 7477.074 | uM | inf | inf | 0.5030 | 0.5030 | 0.0000 | 0.1633 | 0.4030 | 0.6324 | |
| LY2 | HR+ | Luminal | Everolimus | MTOR | MTOR | 12319.156 | uM | 0.04161 | 0.21099 | -0.1875 | -0.3108 | 0.2978 | 0.6003 | 0.8851 | 1.2070 | |
| LY2 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 7477.084 | uM | 0.00794 | 0.01777 | -0.9982 | -1.0000 | 1.3641 | 1.1602 | 0.9984 | 0.9476 | |
| LY2 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 10816.149 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0238 | -0.1642 | 0.4545 | |
| LY2 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 12319.166 | uM | inf | inf | 0.4592 | 0.4592 | 0.0000 | 0.2482 | 0.3896 | 1.3789 | |
| LY2 | HR+ | Luminal | FTase Inhibitor I | Ftase | MAPK | 12319.167 | uM | inf | inf | 0.5142 | 0.5142 | 0.0000 | 0.2423 | -0.0087 | 1.2676 | |
| LY2 | HR+ | Luminal | Gefitinib | EGFR | ErbB | 10264.024 | uM | 25.92930 | 87.30260 | 0.4027 | -1.0000 | 0.9049 | 0.1136 | 0.6077 | 1.2223 | |
| LY2 | HR+ | Luminal | Gefitinib | EGFR | ErbB | 7865.016 | uM | 35.70420 | 38.80070 | 0.5990 | -0.2547 | 4.9509 | -0.0199 | 0.8958 | 1.8047 | |
| LY2 | HR+ | Luminal | Gefitinib | EGFR | ErbB | 9536.019 | uM | 23.67790 | 53.88280 | 0.3153 | -0.9720 | 1.3131 | 0.0656 | 0.9923 | 1.5595 | |
| LY2 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 10264.024 | uM | 0.03199 | 0.04163 | -0.2424 | -0.2295 | 1.4346 | 0.7421 | 0.9942 | 1.2223 | |
| LY2 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 9536.012 | uM | 0.10678 | 0.15177 | -0.3348 | -0.2847 | 1.2818 | 0.6292 | 0.9960 | 1.4096 | |
| LY2 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 10264.131 | uM | inf | inf | 0.2519 | 0.2519 | 0.0000 | 0.4839 | 0.4210 | 1.4548 |