Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset - HMS LINCS Database

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Small molecules	Cells	Antibodies

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Cell	Clinical Subtype	Transcriptional Subtype	Small Molecule	Perturbagen Target	Perturbagen Class	Biological Replicate ID	Conc Unit	GR50	GEC50	GRmax	GRinf	GR Hill Coefficient	GR_AOC	GR r2	Nominal Division Rate
MCF 10A	NM	Basal B	Disulfiram	Proteasome	Proteasome	12944.174	uM	inf	inf	0.7857	0.7857	0.0000	0.1217	0.4057	2.7985
MCF 10A	NM	Basal B	Docetaxel	TUBB	TUBB	9551.002	uM	0.00319	0.00422	-0.1619	-0.1867	1.1322	0.7043	0.9806	2.5642
MCF 10A	NM	Basal B	Docetaxel	TUBB	TUBB	12944.002	uM	0.00427	0.00446	-0.0196	-0.0200	0.9350	0.6124	0.9841	2.6856
MCF 10A	NM	Basal B	Docetaxel	TUBB	TUBB	7870.002	uM	0.00325	0.00288	0.1066	0.0714	1.2804	0.5829	0.9881	2.4447
MCF 10A	NM	Basal B	Docetaxel	TUBB	TUBB	7867.002	uM	0.00341	0.00309	0.0793	0.0606	1.2920	0.5837	0.9918	2.3763
MCF 10A	NM	Basal B	Doxorubicin	TOP2	TOP	9551.121	uM	0.25152	0.63585	-0.6995	-0.7668	1.0024	0.6901	0.9874	2.7416
MCF 10A	NM	Basal B	Doxorubicin	TOP2	TOP	7870.007	uM	0.19862	0.32968	-0.8598	-0.8459	1.9540	0.8262	0.9946	2.0710
MCF 10A	NM	Basal B	Epirubicin	TOP2	TOP	7867.017	uM	0.29421	0.40107	-0.7942	-0.7508	2.9594	0.8491	0.9882	2.5255
MCF 10A	NM	Basal B	Epirubicin	TOP2	TOP	9551.017	uM	0.29670	0.42488	-0.7121	-0.7017	2.4421	0.8016	0.9910	2.5886
MCF 10A	NM	Basal B	Epirubicin	TOP2	TOP	7870.017	uM	0.31849	0.43889	-0.9394	-0.8660	3.1343	0.8589	0.9970	2.0447
MCF 10A	NM	Basal B	Erlotinib	EGFR	ErbB	7484.09	uM	1.93170	3.34270	-0.0487	-0.2143	0.6504	0.3081	0.9911	2.6525
MCF 10A	NM	Basal B	Erlotinib	EGFR	ErbB	7483.091	uM	2.19190	2.52950	-0.0587	-0.0974	1.2421	0.2939	0.9968	3.0465
MCF 10A	NM	Basal B	Erlotinib	EGFR	ErbB	7485.092	uM	2.71020	1.84470	0.2084	0.1437	0.8807	0.2027	0.9985	3.6408
MCF 10A	NM	Basal B	Etoposide	TOP2	TOP	7484.074	uM	16.44680	29.48960	0.1342	-0.1689	0.4983	0.2717	0.9722	2.6137
MCF 10A	NM	Basal B	Etoposide	TOP2	TOP	7485.074	uM	15.31060	187.97350	-0.1329	-1.0000	0.4381	0.2952	0.9748	3.5413
MCF 10A	NM	Basal B	Etoposide	TOP2	TOP	7483.074	uM	8.83460	38.17020	-0.0681	-0.4758	0.4570	0.3237	0.9803	3.2613
MCF 10A	NM	Basal B	Everolimus	MTOR	MTOR	11056.156	uM	5.13780	19.52290	-0.7096	-1.0000	0.8230	0.3395	0.8509	2.5844
MCF 10A	NM	Basal B	Fascaplysin	CDK4	CDK	7485.085	uM	0.38068	0.51769	-0.5759	-0.5322	2.3577	0.4987	0.9979	3.6369
MCF 10A	NM	Basal B	Fascaplysin	CDK4	CDK	7484.084	uM	0.37434	0.49507	-0.6886	-0.6809	3.0746	0.5446	0.9980	2.6217
MCF 10A	NM	Basal B	Fascaplysin	CDK4	CDK	7483.084	uM	0.52191	0.66339	-0.4665	-0.4620	2.7284	0.4526	0.9996	3.2830
MCF 10A	NM	Basal B	FR180204	ERK1/2	MAPK	11056.149	uM	49.1670	47.38650	0.8659	0.0842	4.9997	0.0119	0.6025	2.9204
MCF 10A	NM	Basal B	FTase Inhibitor I	Ftase	MAPK	11056.154	uM	inf	inf	0.8956	0.8956	0.0000	0.0427	0.0000	2.9341
MCF 10A	NM	Basal B	Gefitinib	EGFR	ErbB	9551.132	uM	inf	inf	0.7505	0.7505	0.0000	0.0283	0.4755	2.8612
MCF 10A	NM	Basal B	Gefitinib	EGFR	ErbB	7868.016	uM	0.76989	1.8230	-0.8265	-0.7821	1.0924	0.3828	0.9558	2.0998
MCF 10A	NM	Basal B	Gefitinib	EGFR	ErbB	7870.016	uM	0.49921	0.65150	-0.5476	-0.3625	2.0478	0.3943	0.9754	2.1045

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HMS LINCS Project

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)