Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LY2 | HR+ | Luminal | LBH589 | HDAC | HDAC | 12319.167 | uM | 0.02773 | 0.12090 | -0.9159 | -1.0000 | 0.7461 | 0.8921 | 0.9764 | 1.2676 | |
| LY2 | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 12319.167 | uM | 0.15825 | 0.47441 | -0.9708 | -1.0000 | 1.0006 | 0.7010 | 0.9853 | 1.2676 | |
| LY2 | HR+ | Luminal | Mebendazole | 12627.174 | uM | 0.50329 | 0.43275 | 0.0237 | 0.1162 | 1.7513 | 0.3409 | 0.9831 | 1.3419 | |||
| LY2 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 7477.084 | uM | inf | inf | 0.4295 | 0.4295 | 0.0000 | 0.3986 | 0.4934 | 0.9476 | |
| LY2 | HR+ | Luminal | Methylglyoxal | 13639.184 | uM | inf | inf | -0.8274 | -0.8274 | 0.0000 | 0.3747 | 0.4895 | 1.5976 | |||
| LY2 | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 14134.189 | uM | inf | inf | -0.3706 | -0.3706 | 0.0000 | 0.2938 | 0.5072 | 2.7572 | |
| LY2 | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 14134.189 | uM | inf | inf | -0.3706 | -0.3706 | 0.0000 | 0.2938 | 0.5072 | 2.7572 | |
| LY2 | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 12319.17 | uM | 0.22251 | 0.27719 | -0.9999 | -1.0000 | 5.0000 | 0.9111 | 0.9545 | 0.4684 | |
| LY2 | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 12319.17 | uM | 0.22251 | 0.27719 | -0.9999 | -1.0000 | 5.0000 | 0.9111 | 0.9545 | 0.4684 | |
| LY2 | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 10816.145 | uM | 0.22071 | 0.27486 | -0.9983 | -0.9977 | 5.0000 | 0.8771 | 0.9969 | 0.7766 | |
| LY2 | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 10816.145 | uM | 0.22071 | 0.27486 | -0.9983 | -0.9977 | 5.0000 | 0.8771 | 0.9969 | 0.7766 | |
| LY2 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 12319.135 | uM | 0.08180 | 0.10116 | -0.9468 | -0.9099 | 4.8799 | 0.9801 | 0.9968 | 0.3806 | |
| LY2 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 10816.148 | uM | 0.16358 | 0.24353 | -0.7404 | -0.7173 | 2.2359 | 0.7251 | 0.9980 | 0.7402 | |
| LY2 | HR+ | Luminal | Nelfinavir | 12627.174 | uM | 8.39840 | 12.76790 | -0.8520 | -1.0000 | 2.6227 | 0.1651 | 0.9984 | 1.3419 | |||
| LY2 | HR+ | Luminal | Nilotinib | ABL | nRTK | 10816.145 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0123 | -0.0004 | 0.7766 | |
| LY2 | HR+ | Luminal | Nilotinib | ABL | nRTK | 12319.17 | uM | inf | inf | 0.9335 | 0.9335 | 0.0000 | 0.1304 | 0.1701 | 0.4684 | |
| LY2 | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 10816.152 | uM | 0.48617 | 1.24280 | -0.9738 | -1.0000 | 1.1706 | 0.8282 | 0.9683 | 1.0111 | |
| LY2 | HR+ | Luminal | NU6102 | CDK1/2 | CDK | 12319.147 | uM | 18.25020 | 28.30340 | -0.7907 | -0.9998 | 2.5033 | 0.2886 | 0.8469 | 1.1783 | |
| LY2 | HR+ | Luminal | NU6102 | CDK1/2 | CDK | 10816.147 | uM | 31.85780 | 39.68620 | -0.8650 | -1.0000 | 5.0000 | 0.1140 | 0.9659 | 0.7283 | |
| LY2 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 7477.066 | uM | 5.95670 | 7.42050 | -1.0000 | -1.0000 | 5.0000 | 0.4047 | 0.9709 | 0.3409 | |
| LY2 | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 10380.066 | uM | 5.08760 | 12.14760 | -0.8275 | -1.0000 | 1.2623 | 0.2564 | 0.9954 | 1.2245 | |
| LY2 | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 12319.147 | uM | 2.25940 | 5.91090 | -0.9046 | -1.0000 | 1.1424 | 0.6134 | 0.9123 | 1.1783 | |
| LY2 | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 10816.147 | uM | 5.0970 | 6.34790 | -0.9997 | -0.9981 | 5.0000 | 0.4155 | 0.9979 | 0.7283 | |
| LY2 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 10380.087 | uM | 0.0120 | 0.02509 | -0.7779 | -0.7670 | 1.2601 | 0.9793 | 0.9962 | 1.3481 | |
| LY2 | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 9536.011 | uM | 7.84540 | 27.8330 | -0.9125 | -1.0000 | 0.8676 | 0.5254 | 0.9629 | 1.2640 |