Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset - HMS LINCS Database

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Small molecules	Cells	Antibodies

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Cell	Clinical Subtype	Transcriptional Subtype	Small Molecule	Antibody	Perturbagen Target	Perturbagen Class	Biological Replicate ID	Conc Unit	GR50	GEC50	GRmax	GRinf	GR Hill Coefficient	GR_AOC	GR r2	Nominal Division Rate
MCF 10A	NM	Basal B	Temsirolimus		MTOR	MTOR	11056.144	uM	2.42720	24.19480	-0.6770	-1.0000	0.4778	0.4247	0.8799	2.8424
MCF 10A	NM	Basal B	Topotecan		TOP1	TOP	7870.007	uM	0.09852	0.52219	-0.7793	-0.9193	0.6256	0.8238	0.9875	2.0710
MCF 10A	NM	Basal B	Topotecan		TOP1	TOP	9551.121	uM	0.14549	0.94182	-0.6234	-0.8039	0.5132	0.6861	0.9897	2.7416
MCF 10A	NM	Basal B	Torkinib				15392.211	uM	0.09065	0.05717	0.1059	0.1141	0.5621	0.4665	0.9882	2.9667
MCF 10A	NM	Basal B	Tozasertib		AURK/FLT3/ABL/JAK2	AURK	11056.15	uM	4.25490	9.16210	0.2253	-0.1815	0.4037	0.2101	0.9544	3.0207
MCF 10A	NM	Basal B	TPCA-1		IKK	NFKB	7485.093	uM	6.39950	5.74660	0.0979	0.0862	1.7585	0.1771	0.9982	3.5766
MCF 10A	NM	Basal B	Trametinib		MEK	MAPK	7867.036	uM	0.00791	0.00675	-0.0327	0.0848	1.1700	0.5437	0.9810	2.2053
MCF 10A	NM	Basal B	Trametinib		MEK	MAPK	7868.05	uM	0.00940	0.00831	0.0550	0.0904	1.6251	0.5275	0.9950	2.0672
MCF 10A	NM	Basal B	Trametinib		MEK	MAPK	9551.012	uM	0.00733	0.00636	0.1316	0.1356	2.2386	0.5355	0.9963	2.7057
MCF 10A	NM	Basal B	Trametinib		MEK	MAPK	7870.012	uM	0.00915	0.00756	0.0892	0.1088	1.2843	0.5296	0.9980	2.3112
MCF 10A	NM	Basal B		Trastuzumab	HER2	ErbB	9551.026	uM	inf	inf	0.9124	0.9124	0.0000	-0.0111	0.4645	2.6508
MCF 10A	NM	Basal B	Trichostatin A		HDAC	HDAC	7484.065	uM	18.74420	41.72610	-0.7775	-0.7559	1.1509	0.6385	0.9975	2.3857
MCF 10A	NM	Basal B	Trichostatin A		HDAC	HDAC	7485.065	uM	28.32790	56.52840	-0.4782	-0.4940	0.9945	0.5158	0.9984	3.5869
MCF 10A	NM	Basal B	Trichostatin A		HDAC	HDAC	7483.065	uM	21.97690	39.36970	-0.5162	-0.5201	1.2230	0.5796	0.9993	3.0487
MCF 10A	NM	Basal B	Triciribine		AKT	AKT	7483.074	uM	1.68540	11.43670	0.1197	-0.4802	0.3515	0.2863	0.9878	3.2613
MCF 10A	NM	Basal B	Triciribine		AKT	AKT	7484.074	uM	0.65898	1.60360	0.0276	-0.2269	0.4208	0.3354	0.9903	2.6137
MCF 10A	NM	Basal B	Triciribine		AKT	AKT	7485.074	uM	1.94840	26.26440	0.1167	-0.6967	0.3355	0.2816	0.9922	3.5413
MCF 10A	NM	Basal B	Valproic acid		HDAC	HDAC	11056.143	uM	702.02350	1000.00000	-0.6298	-0.3399	1.4659	0.2242	0.9123	2.8628
MCF 10A	NM	Basal B	Vinorelbine		TUBB	TUBB	7870.018	uM	0.03238	0.03842	-0.7364	-0.2435	2.3170	0.6886	0.8696	2.2478
MCF 10A	NM	Basal B	Vinorelbine		TUBB	TUBB	7867.042	uM	0.01177	0.01245	-0.6816	-0.1609	4.9999	0.7168	0.8832	2.3427
MCF 10A	NM	Basal B	Vinorelbine		TUBB	TUBB	7868.018	uM	0.03803	0.04346	-0.7472	-0.2455	2.9889	0.6376	0.9065	2.1110
MCF 10A	NM	Basal B	Vorinostat		HDAC	HDAC	7483.065	uM	234.78130	497.97180	-0.3871	-0.4448	0.8464	0.4040	0.9957	3.0487
MCF 10A	NM	Basal B	Vorinostat		HDAC	HDAC	7484.065	uM	327.82880	879.89750	-0.7361	-0.8346	0.9944	0.4311	0.9957	2.3857
MCF 10A	NM	Basal B	Vorinostat		HDAC	HDAC	7485.065	uM	376.22630	511.40920	-0.1618	-0.1983	1.0882	0.3267	0.9967	3.5869
MCF 10A	NM	Basal B	XRP44X		ELK3	MAPK	11056.151	uM	0.35713	0.35089	0.0205	0.0422	5.0000	0.4286	0.9989	3.0292

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HMS LINCS Project

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)