Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
LY2
HR+
Luminal
 XRP44X
ELK3
MAPK
10816.151
uM
0.63031
0.71266
 -0.4513 -0.4239 5.0000 0.5934
0.9944
 0.9672
LY2
HR+
Luminal
 Z-Leu-Leu-Norvalinal
Proteasome
Proteasome
14134.189
uM
3.01790
3.82350
 -0.3296 -0.3329 2.1565 0.2847
0.9966
 2.7572
LY2
HR+
Luminal
 ZM-447439
AURK
AURK
12319.169
uM
inf
inf
 0.3374 0.3374 0.0000 0.2734
0.4729
 0.9948
LY2
HR+
Luminal
 ZM-447439
AURK
AURK
10816.15
uM
inf
inf
 1.0500 1.0500 0.0000 -0.0500
-inf
 0.3031
MB 157
Unknown
Unknown
 (Z)-4-Hydroxytamoxifen
ESR1
9039.016
uM
56.67380
1000.00000
 0.2424 -0.8928 0.3569 0.1994
0.6376
 0.5468
MB 157
Unknown
Unknown
 17-AAG
HSP90
HSP90
9039.05
uM
0.12547
0.19845
 -0.9559 -0.8699 2.1984 0.8996
0.9931
 0.4285
MB 157
Unknown
Unknown
 5-DFUR
TYMS
TYMS
12580.143
uM
10.78580
8.72060
 0.0852 0.2270 2.8463 0.3694
0.9745
 2.2318
MB 157
Unknown
Unknown
 Afatinib
EGFR/HER2
ErbB
12580.165
uM
0.02446
0.53837
 -0.7389 -1.0000 0.3553 0.7931
0.9550
 2.2883
MB 157
Unknown
Unknown
 AG1024
IGF1R
RTK
7482.066
uM
inf
inf
 1.0500 1.0500 0.0000 0.0332
-0.0335
 1.1347
MB 157
Unknown
Unknown
 AG1478
EGFR
ErbB
9039.016
uM
inf
inf
 -0.3711 -0.3711 0.0000 0.3841
0.5565
 0.5468
MB 157
Unknown
Unknown
 AS-252424
PI3K
PI3K
12580.165
uM
inf
inf
 0.9815 0.9815 0.0000 0.0012
0.1111
 2.2883
MB 157
Unknown
Unknown
 Bortezomib
Proteasome
Proteasome
7482.074
uM
0.06606
0.12226
 -0.9072 -0.9152 1.6901 1.0906
0.9972
 1.7663
MB 157
Unknown
Unknown
 Bortezomib
Proteasome
Proteasome
7482.074
uM
0.06606
0.12226
 -0.9072 -0.9152 1.6901 1.0906
0.9972
 1.7663
MB 157
Unknown
Unknown
 Bosutinib
Src
nRTK
12580.17
uM
0.23378
0.96284
 -0.6288 -0.8257 0.6889 0.5094
0.9755
 1.9993
MB 157
Unknown
Unknown
 CPT-11
TOP1
TOP
9039.078
uM
3.48660
7.04560
 -0.9875 -1.0000 1.5617 0.3981
0.9915
 0.6306
MB 157
Unknown
Unknown
 Dactolisib
PI3K
PI3K
12580.155
uM
0.15405
0.11476
 0.2968 0.2441 2.2754 0.3494
0.9739
 2.2315
MB 157
Unknown
Unknown
 Doxorubicin
TOP2
TOP
9039.078
uM
0.07987
0.15879
 -1.0000 -1.0000 1.5989 1.0364
0.9906
 0.6306
MB 157
Unknown
Unknown
 Erlotinib
EGFR
ErbB
7482.091
uM
0.1180
1.89770
 -0.3261 -0.6655 0.3047 0.5539
0.9073
 1.9368
MB 157
Unknown
Unknown
 Etoposide
TOP2
TOP
7482.074
uM
0.18831
0.56350
 -0.8009 -0.6662 0.7727 0.8202
0.9535
 1.7663
MB 157
Unknown
Unknown
 Everolimus
MTOR
MTOR
12580.164
uM
0.21629
454.8150
 0.0020 -1.0000 0.1436 0.4876
0.8287
 2.0914
MB 157
Unknown
Unknown
 Fascaplysin
CDK4
CDK
7482.084
uM
0.12446
0.15235
 -0.9397 -0.8743 5.0000 0.7825
0.9980
 1.8697
MB 157
Unknown
Unknown
 FR180204
ERK1/2
MAPK
12580.166
uM
41.2180
19.53060
 0.4213 0.4065 2.2451 0.0457
0.9696
 1.8686
MB 157
Unknown
Unknown
 FTase Inhibitor I
Ftase
MAPK
12580.167
uM
inf
inf
 1.0233 1.0233 0.0000 -0.0124
-0.4459
 2.1970
MB 157
Unknown
Unknown
 Gefitinib
EGFR
ErbB
9039.016
uM
3.54030
10.82390
 -0.5859 -1.0000 0.9831 0.3413
0.8529
 0.5468
MB 157
Unknown
Unknown
 Glycyl-H-1152
ROCK2
12580.169
uM
2.21430
2.9020
 -0.2656 -0.2333 1.4159 0.2752
0.9908
 2.1524