Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LY2 | HR+ | Luminal | Taxol | TUBB | TUBB | 9536.002 | uM | 0.01084 | 0.01337 | -0.3863 | -0.2961 | 2.2129 | 0.7657 | 0.9928 | 1.3627 | |
| LY2 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 10816.152 | uM | 0.21478 | 0.64415 | -0.9742 | -1.0000 | 1.0003 | 0.6827 | 0.9825 | 1.0111 | |
| LY2 | HR+ | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 10816.148 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.7402 | |
| LY2 | HR+ | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 12319.135 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.3806 | |
| LY2 | HR+ | Luminal | Temsirolimus | MTOR | MTOR | 12319.168 | uM | 0.05481 | 2.32860 | -0.9885 | -1.0000 | 0.2930 | 0.7272 | 0.8342 | 0.9560 | |
| LY2 | HR+ | Luminal | Temsirolimus | MTOR | MTOR | 10816.144 | uM | 0.17417 | 3.49250 | -0.9847 | -1.0000 | 0.3664 | 0.6354 | 0.8650 | 0.9146 | |
| LY2 | HR+ | Luminal | Topotecan | TOP1 | TOP | 10264.121 | uM | 0.28155 | 1.02050 | -0.3709 | -0.5394 | 0.5683 | 0.5872 | 0.9712 | 1.3643 | |
| LY2 | HR+ | Luminal | Torkinib | 15391.211 | uM | 0.00743 | 0.00789 | -0.0237 | -0.0145 | 0.4813 | 0.6703 | 0.9914 | 1.2835 | |||
| LY2 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 12319.169 | uM | 0.83834 | 8.04070 | -0.9492 | -1.0000 | 0.4859 | 0.5381 | 0.7850 | 0.9948 | |
| LY2 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 10816.15 | uM | 21.64110 | 26.9580 | -0.4840 | -0.9997 | 5.0000 | 0.0458 | 0.9904 | 0.3031 | |
| LY2 | HR+ | Luminal | TPCA-1 | IKK | NFKB | 10380.093 | uM | 23.58160 | 13.81610 | 0.4657 | 0.4655 | 5.0000 | 0.0314 | 0.9632 | 1.4880 | |
| LY2 | HR+ | Luminal | Trametinib | MEK | MAPK | 7865.05 | uM | inf | inf | 0.9133 | 0.9133 | 0.0000 | 0.0469 | 0.0653 | 1.5015 | |
| LY2 | HR+ | Luminal | Trametinib | MEK | MAPK | 10264.024 | uM | inf | 998.55080 | 0.6181 | -0.1985 | 0.2283 | 0.1218 | 0.6493 | 1.2223 | |
| LY2 | HR+ | Luminal | Trametinib | MEK | MAPK | 9536.012 | uM | inf | 0.00536 | 0.8520 | 0.8999 | 4.9998 | 0.0482 | 0.7947 | 1.4096 | |
| LY2 | HR+ | Luminal | Trastuzumab | HER2 | ErbB | 10264.026 | uM | inf | inf | 0.8544 | 0.8544 | 0.0000 | 0.0234 | 0.5438 | 1.5047 | |
| LY2 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 7477.065 | uM | 6.29540 | 8.97720 | -0.9995 | -0.9667 | 3.0326 | 0.9357 | 0.9982 | 0.7891 | |
| LY2 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 10380.065 | uM | 13.82370 | 21.29030 | -0.8629 | -0.8449 | 2.2911 | 0.7651 | 0.9988 | 1.4916 | |
| LY2 | HR+ | Luminal | Triciribine | AKT | AKT | 7477.074 | uM | 0.04229 | 0.04632 | -0.4707 | -0.2864 | 4.9767 | 0.7738 | 0.7851 | 0.6324 | |
| LY2 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 12319.143 | uM | 811.01570 | 1000.00000 | -0.9998 | -0.9250 | 5.0000 | 0.5128 | 0.8284 | 0.5178 | |
| LY2 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 10816.143 | uM | 391.61530 | 999.99910 | -0.9998 | -1.0000 | 1.1719 | 0.4856 | 0.8408 | 0.4975 | |
| LY2 | HR+ | Luminal | Vinorelbine | TUBB | TUBB | 7865.018 | uM | 0.00534 | 0.10713 | -0.8752 | -1.0000 | 0.3663 | 0.9556 | 0.7249 | 1.1920 | |
| LY2 | HR+ | Luminal | Vinorelbine | TUBB | TUBB | 9536.006 | uM | 0.01210 | 0.01775 | -0.9391 | -0.5555 | 1.9509 | 1.1989 | 0.8561 | 1.2564 | |
| LY2 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 7477.065 | uM | 164.46940 | 242.89610 | -0.9995 | -0.9975 | 2.8133 | 0.6664 | 0.9940 | 0.7891 | |
| LY2 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 10380.065 | uM | 183.80930 | 309.8820 | -0.8951 | -0.8783 | 1.9415 | 0.5830 | 0.9978 | 1.4916 | |
| LY2 | HR+ | Luminal | XRP44X | ELK3 | MAPK | 12319.157 | uM | 2.07920 | 2.38150 | -0.5120 | -0.4858 | 4.9995 | 0.5206 | 0.9368 | 1.0058 |