Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | TNBC | Basal B | LBH589 | HDAC | HDAC | 10694.154 | uM | 0.35767 | 0.53878 | -0.7298 | -0.7139 | 2.1649 | 0.5471 | 0.9980 | 2.3045 | |
| Hs 578T | TNBC | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 10694.154 | uM | 1.640 | 5.84010 | -0.7169 | -1.0000 | 0.8650 | 0.3094 | 0.9919 | 2.3045 | |
| Hs 578T | TNBC | Basal B | Mebendazole | 12622.174 | uM | 0.40335 | 0.33584 | 0.0053 | 0.1511 | 1.9636 | 0.3432 | 0.9749 | 2.4358 | |||
| Hs 578T | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 7475.084 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0415 | -7.3003 | 2.7804 | |
| Hs 578T | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 7474.084 | uM | inf | inf | 0.8512 | 0.8512 | 0.0000 | 0.0976 | 0.4506 | 2.6631 | |
| Hs 578T | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 7473.084 | uM | inf | 1.15530 | 0.8363 | 0.8597 | 4.9999 | 0.0505 | 0.7918 | 2.0337 | |
| Hs 578T | TNBC | Basal B | Methylglyoxal | 13504.184 | uM | 353.9910 | 544.55710 | -0.9422 | -0.9506 | 2.4730 | 0.7442 | 0.9699 | 1.9883 | |||
| Hs 578T | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 14260.189 | uM | inf | inf | -0.9845 | -0.9845 | 0.0000 | 0.6451 | 0.5575 | 1.5886 | |
| Hs 578T | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 14260.189 | uM | inf | inf | -0.9845 | -0.9845 | 0.0000 | 0.6451 | 0.5575 | 1.5886 | |
| Hs 578T | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 14158.189 | uM | 0.17168 | 0.18931 | -0.8774 | -0.3153 | 5.0000 | 0.6799 | 0.5842 | 1.7834 | |
| Hs 578T | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 14158.189 | uM | 0.17168 | 0.18931 | -0.8774 | -0.3153 | 5.0000 | 0.6799 | 0.5842 | 1.7834 | |
| Hs 578T | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 10694.145 | uM | 0.21666 | 0.30129 | -0.7988 | -0.7679 | 2.8221 | 0.7556 | 0.9987 | 2.2732 | |
| Hs 578T | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 10694.145 | uM | 0.21666 | 0.30129 | -0.7988 | -0.7679 | 2.8221 | 0.7556 | 0.9987 | 2.2732 | |
| Hs 578T | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 10694.148 | uM | 0.34708 | 0.83278 | -0.3037 | -0.3879 | 0.6561 | 0.4957 | 0.9874 | 2.4626 | |
| Hs 578T | TNBC | Basal B | Nelfinavir | 12622.174 | uM | 9.16330 | 14.61050 | -0.7502 | -1.0000 | 2.3548 | 0.1522 | 0.9989 | 2.4358 | |||
| Hs 578T | TNBC | Basal B | Nilotinib | ABL | nRTK | 10694.145 | uM | inf | 10.83450 | 0.6363 | 0.6824 | 4.9999 | 0.1000 | 0.7935 | 2.2732 | |
| Hs 578T | TNBC | Basal B | NSC 663284 | CDC25 | CDC | 10694.152 | uM | 1.76060 | 2.19680 | -0.7631 | -0.7576 | 4.1672 | 0.5809 | 0.9994 | 2.4238 | |
| Hs 578T | TNBC | Basal B | NU6102 | CDK1/2 | CDK | 10694.147 | uM | 26.35390 | 35.37370 | 0.0133 | -0.3234 | 1.6947 | 0.0918 | 0.9988 | 2.3818 | |
| Hs 578T | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 7475.066 | uM | inf | inf | 0.9761 | 0.9761 | 0.0000 | -0.0283 | -0.7384 | 2.7689 | |
| Hs 578T | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 7472.066 | uM | inf | inf | 0.9265 | 0.9265 | 0.0000 | -0.0306 | 0.0660 | 1.8363 | |
| Hs 578T | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 7473.066 | uM | inf | inf | 0.8693 | 0.8693 | 0.0000 | -0.0333 | 0.3931 | 2.3582 | |
| Hs 578T | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 7474.066 | uM | inf | 60.4740 | 0.7403 | 0.5492 | 3.1058 | 0.0106 | 0.8617 | 2.7948 | |
| Hs 578T | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 7471.066 | uM | 41.46010 | 152.06380 | 0.3265 | -1.0000 | 0.8454 | 0.0864 | 0.9724 | 2.2865 | |
| Hs 578T | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 10379.066 | uM | 54.29080 | 122.85870 | 0.3901 | -0.9861 | 1.3338 | 0.0424 | 0.9869 | 2.3931 | |
| Hs 578T | TNBC | Basal B | Olomoucine II | CDK1 | CDK | 10694.147 | uM | 9.3240 | 9.56940 | 0.0794 | -0.0141 | 1.0685 | 0.2323 | 0.9688 | 2.3818 |