Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC70 | TNBC | Basal A | Oxaliplatin | DNA cross-linker | DNA cross-linker | 9501.011 | uM | 4.62120 | 7.58710 | -0.9939 | -1.0000 | 2.2158 | 0.7353 | 0.9794 | 0.9301 | |
| HCC70 | TNBC | Basal A | Oxaliplatin | DNA cross-linker | DNA cross-linker | 7857.011 | uM | 3.89290 | 7.60720 | -0.9821 | -1.0000 | 1.6399 | 0.7364 | 0.9828 | 1.0477 | |
| HCC70 | TNBC | Basal A | Oxaliplatin | DNA cross-linker | DNA cross-linker | 7860.011 | uM | 6.49970 | 9.5290 | -0.9971 | -0.9987 | 2.8694 | 0.6551 | 0.9973 | 0.7135 | |
| HCC70 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 10873.147 | uM | 0.58409 | 1.46030 | -0.9458 | -1.0000 | 1.1989 | 0.6467 | 0.9886 | 1.2965 | |
| HCC70 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 12400.147 | uM | 0.36563 | 0.82711 | -0.9479 | -0.9829 | 1.3318 | 0.7071 | 0.9956 | 1.2599 | |
| HCC70 | TNBC | Basal A | PD 98059 | MEK | MAPK | 12400.152 | uM | inf | inf | 0.7537 | 0.7537 | 0.0000 | 0.0534 | -0.0064 | 1.1392 | |
| HCC70 | TNBC | Basal A | PD 98059 | MEK | MAPK | 10873.152 | uM | inf | inf | 0.6866 | 0.6866 | 0.0000 | 0.1030 | 0.4802 | 1.1577 | |
| HCC70 | TNBC | Basal A | PD173074 | FGFR1/3 | RTK | 7470.093 | uM | 7.20970 | 7.7470 | -0.2154 | -0.2163 | 5.0000 | 0.1443 | 0.9845 | 1.0798 | |
| HCC70 | TNBC | Basal A | PD184352 | MEK | MAPK | 12400.155 | uM | 52.17950 | 491.15770 | 0.5527 | -1.0000 | 0.4900 | 0.1062 | 0.7897 | 1.2558 | |
| HCC70 | TNBC | Basal A | PD184352 | MEK | MAPK | 12400.155 | uM | 52.17950 | 491.15770 | 0.5527 | -1.0000 | 0.4900 | 0.1062 | 0.7897 | 1.2558 | |
| HCC70 | TNBC | Basal A | PD184352 | MEK | MAPK | 10873.155 | uM | 18.5150 | 0.97132 | 0.4137 | 0.2888 | 0.2924 | 0.2477 | 0.8360 | 1.2787 | |
| HCC70 | TNBC | Basal A | PD184352 | MEK | MAPK | 10873.155 | uM | 18.5150 | 0.97132 | 0.4137 | 0.2888 | 0.2924 | 0.2477 | 0.8360 | 1.2787 | |
| HCC70 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7470.095 | uM | inf | inf | 0.6946 | 0.6946 | 0.0000 | 0.1485 | 0.1176 | 1.1893 | |
| HCC70 | TNBC | Basal A | PS-1145 | IKK | NFKB | 7470.065 | uM | inf | 997.07810 | 0.8477 | 0.8264 | 3.0748 | -0.0089 | 0.6820 | 1.0127 | |
| HCC70 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 7470.067 | uM | inf | 50.32940 | 0.7235 | 0.7215 | 4.0974 | 0.0304 | 0.7160 | 1.0774 | |
| HCC70 | TNBC | Basal A | QNZ | NFkB | NFKB | 7470.096 | uM | 0.05215 | 0.04968 | -0.0420 | 0.0351 | 1.5003 | 0.4945 | 0.9857 | 0.9576 | |
| HCC70 | TNBC | Basal A | Ribavirin | 15390.211 | uM | inf | inf | 0.3573 | 0.3573 | 0.0000 | 0.3033 | -0.0164 | 0.5021 | |||
| HCC70 | TNBC | Basal A | SB-3CT | MMP2/9 | MMP | 12400.168 | uM | inf | 8.51570 | 0.9069 | 0.9261 | 4.9761 | 0.0190 | 0.6824 | 1.3275 | |
| HCC70 | TNBC | Basal A | SB-3CT | MMP2/9 | MMP | 10873.144 | uM | 176.76750 | 35.18930 | 0.5319 | 0.4864 | 2.2323 | 0.0396 | 0.9573 | 1.2304 | |
| HCC70 | TNBC | Basal A | Selumetinib | MEK | MAPK | 10873.155 | uM | 1.08470 | 78.79490 | -0.0634 | -0.9980 | 0.2560 | 0.3505 | 0.8349 | 1.2787 | |
| HCC70 | TNBC | Basal A | Selumetinib | MEK | MAPK | 12400.155 | uM | 11.73270 | 0.19905 | 0.4757 | 0.4162 | 0.4381 | 0.2576 | 0.9939 | 1.2558 | |
| HCC70 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 10873.153 | uM | 1.54160 | 4.94680 | -0.7692 | -0.9324 | 0.9027 | 0.4284 | 0.9873 | 1.3397 | |
| HCC70 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 12400.165 | uM | 2.21440 | 7.17070 | -0.8387 | -1.0000 | 0.9350 | 0.3886 | 0.9922 | 1.3057 | |
| HCC70 | TNBC | Basal A | Sirolimus | MTOR | MTOR | 7858.068 | uM | 0.11781 | 11.74330 | -0.3355 | -1.0000 | 0.2387 | 0.6390 | 0.8978 | 1.2106 | |
| HCC70 | TNBC | Basal A | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7470.085 | uM | 37.73390 | 70.33160 | -0.9561 | -1.0000 | 1.7644 | 0.2890 | 0.9885 | 0.9880 |