Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC70 | TNBC | Basal A | LBH589 | HDAC | HDAC | 10873.154 | uM | 0.07768 | 0.13103 | -0.9534 | -0.9626 | 2.0534 | 0.8487 | 0.9994 | 1.1648 | |
| HCC70 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 12400.167 | uM | 0.16431 | 0.49313 | -0.9570 | -0.8404 | 0.8972 | 0.5972 | 0.9772 | 1.2627 | |
| HCC70 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 10873.154 | uM | 0.24958 | 1.13010 | -0.9565 | -1.0000 | 0.7274 | 0.5386 | 0.9918 | 1.1648 | |
| HCC70 | TNBC | Basal A | Mebendazole | 12714.174 | uM | 0.11165 | 0.17592 | -0.9403 | -0.8934 | 2.2542 | 1.0180 | 0.9090 | 0.3306 | |||
| HCC70 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 7470.085 | uM | inf | inf | 0.6898 | 0.6898 | 0.0000 | 0.2374 | 0.0000 | 0.9880 | |
| HCC70 | TNBC | Basal A | Methylglyoxal | 13607.184 | uM | inf | inf | -0.7097 | -0.7097 | 0.0000 | 0.5913 | 0.5266 | 0.8612 | |||
| HCC70 | TNBC | Basal A | MG-132 | Proteasome | Proteasome | 14257.189 | uM | inf | inf | -1.0000 | -1.0000 | 0.0000 | 0.9813 | 0.4558 | 0.3775 | |
| HCC70 | TNBC | Basal A | MG-132 | Proteasome | Proteasome | 14257.189 | uM | inf | inf | -1.0000 | -1.0000 | 0.0000 | 0.9813 | 0.4558 | 0.3775 | |
| HCC70 | TNBC | Basal A | MG-132 | Proteasome | Proteasome | 12400.17 | uM | 0.07474 | 0.11640 | -0.9170 | -0.9300 | 2.3720 | 0.9712 | 0.9984 | 1.1992 | |
| HCC70 | TNBC | Basal A | MG-132 | Proteasome | Proteasome | 12400.17 | uM | 0.07474 | 0.11640 | -0.9170 | -0.9300 | 2.3720 | 0.9712 | 0.9984 | 1.1992 | |
| HCC70 | TNBC | Basal A | MG-132 | Proteasome | Proteasome | 10873.145 | uM | 0.06136 | 0.10266 | -0.9226 | -0.9290 | 2.0405 | 0.9792 | 0.9990 | 1.2454 | |
| HCC70 | TNBC | Basal A | MG-132 | Proteasome | Proteasome | 10873.145 | uM | 0.06136 | 0.10266 | -0.9226 | -0.9290 | 2.0405 | 0.9792 | 0.9990 | 1.2454 | |
| HCC70 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 10873.148 | uM | inf | inf | 0.9161 | 0.9161 | 0.0000 | 0.1719 | 0.0430 | 1.2150 | |
| HCC70 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 12400.135 | uM | 0.15813 | 0.25123 | -0.8344 | -0.8087 | 2.0783 | 0.7902 | 0.9996 | 1.2966 | |
| HCC70 | TNBC | Basal A | Nelfinavir | 12714.174 | uM | 8.95410 | 11.15450 | -1.0000 | -1.0000 | 5.0000 | 0.3201 | 0.8734 | 0.3306 | |||
| HCC70 | TNBC | Basal A | Nilotinib | ABL | nRTK | 12400.17 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0014 | -0.0040 | 1.1992 | |
| HCC70 | TNBC | Basal A | Nilotinib | ABL | nRTK | 10873.145 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0001 | -0.0012 | 1.2454 | |
| HCC70 | TNBC | Basal A | NSC 663284 | CDC25 | CDC | 10873.152 | uM | 2.85030 | 5.92010 | -0.9625 | -1.0000 | 1.5031 | 0.5523 | 0.9855 | 1.1577 | |
| HCC70 | TNBC | Basal A | NSC 663284 | CDC25 | CDC | 12400.152 | uM | 3.32670 | 5.80610 | -0.9357 | -0.9641 | 1.9291 | 0.5522 | 0.9942 | 1.1392 | |
| HCC70 | TNBC | Basal A | NU6102 | CDK1/2 | CDK | 12400.147 | uM | 18.83870 | 25.10 | -0.9561 | -1.0000 | 3.8285 | 0.2311 | 0.9581 | 1.2599 | |
| HCC70 | TNBC | Basal A | NU6102 | CDK1/2 | CDK | 10873.147 | uM | 15.06980 | 21.86720 | -0.9426 | -1.0000 | 2.9509 | 0.2344 | 0.9694 | 1.2965 | |
| HCC70 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 7470.066 | uM | 16.9690 | 35.8280 | -0.4446 | -1.0000 | 1.4700 | 0.2042 | 0.9482 | 1.0766 | |
| HCC70 | TNBC | Basal A | Olomoucine II | CDK1 | CDK | 10873.147 | uM | 4.03480 | 6.95720 | -0.9564 | -1.0000 | 2.0165 | 0.5074 | 0.9908 | 1.2965 | |
| HCC70 | TNBC | Basal A | Olomoucine II | CDK1 | CDK | 12400.147 | uM | 3.99480 | 6.76650 | -0.9567 | -1.0000 | 2.0848 | 0.5109 | 0.9923 | 1.2599 | |
| HCC70 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 7470.086 | uM | 0.00760 | 0.02508 | -0.9413 | -0.9203 | 0.8740 | 1.0811 | 0.9950 | 0.9669 |