Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC70 | TNBC | Basal A | GSK1070916 | AURK | AURK | 9501.001 | uM | 0.25153 | 1.98490 | -0.9456 | -1.0000 | 0.5318 | 0.4992 | 0.9119 | 0.9969 | |
| HCC70 | TNBC | Basal A | GSK1070916 | AURK | AURK | 7857.001 | uM | 0.27450 | 2.71060 | -0.7804 | -1.0000 | 0.4798 | 0.4721 | 0.9462 | 1.1724 | |
| HCC70 | TNBC | Basal A | GSK1838705A | IGF1R | RTK | 7470.098 | uM | 4.43760 | 6.40920 | -0.9759 | -0.9789 | 2.9499 | 0.4511 | 0.9768 | 0.9387 | |
| HCC70 | TNBC | Basal A | GSK1838705A | IGF1R | RTK | 7470.091 | uM | 6.1040 | 7.5870 | -0.9836 | -0.9832 | 4.9994 | 0.4063 | 0.9968 | 0.9773 | |
| HCC70 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 7857.001 | uM | 0.01783 | 0.01709 | -0.4947 | 0.0955 | 5.0000 | 0.5014 | 0.6961 | 1.1724 | |
| HCC70 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 9501.001 | uM | 0.12061 | 1.51280 | -0.9742 | -1.0000 | 0.4344 | 0.5258 | 0.8085 | 0.9969 | |
| HCC70 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 7856.001 | uM | 0.00410 | 0.00442 | -0.4520 | -0.2286 | 5.0000 | 0.8187 | 0.9277 | 0.7111 | |
| HCC70 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 9501.001 | uM | 0.01937 | 0.02238 | -0.5531 | -0.4261 | 4.2630 | 0.7815 | 0.9912 | 0.9969 | |
| HCC70 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 7857.001 | uM | 0.03064 | 0.03781 | -0.6406 | -0.5045 | 3.3202 | 0.7946 | 0.9921 | 1.1724 | |
| HCC70 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 7856.001 | uM | 0.01934 | 0.02539 | -0.8057 | -0.6477 | 3.0518 | 0.8954 | 0.9929 | 0.7111 | |
| HCC70 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 7470.088 | uM | inf | inf | 1.0012 | 1.0012 | 0.0000 | -0.0041 | -0.0107 | 1.1071 | |
| HCC70 | TNBC | Basal A | Ibandronate | FDPS | 12400.143 | uM | 78.39170 | 75.29820 | 0.0680 | 0.0702 | 3.7592 | 0.2421 | 0.9652 | 1.3002 | ||
| HCC70 | TNBC | Basal A | Ibandronate | FDPS | 10873.143 | uM | 57.35250 | 60.53010 | 0.0087 | -0.0377 | 1.3496 | 0.2794 | 0.9925 | 1.2785 | ||
| HCC70 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 10873.151 | uM | inf | 0.50443 | 0.6818 | 0.6342 | 0.3083 | 0.1357 | 0.6273 | 1.1786 | |
| HCC70 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 12400.157 | uM | 384.40030 | 999.98310 | 0.6151 | -0.0973 | 0.1860 | 0.1888 | 0.8228 | 1.1935 | |
| HCC70 | TNBC | Basal A | IKK16 | IKK | NFKB | 7470.093 | uM | 2.83020 | 3.82560 | -0.9704 | -0.9807 | 3.6024 | 0.4488 | 0.9936 | 1.0798 | |
| HCC70 | TNBC | Basal A | Imatinib | ABL/KIT/PDGFR | nRTK | 7470.091 | uM | 18.81990 | 29.20970 | -0.9918 | -1.0000 | 2.4992 | 0.4982 | 0.9904 | 0.9773 | |
| HCC70 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 7470.067 | uM | 0.04022 | 0.04772 | -0.9830 | -0.6232 | 4.7339 | 0.8210 | 0.9629 | 1.0774 | |
| HCC70 | TNBC | Basal A | Ixabepilone | TUBB | TUBB | 7470.095 | uM | 0.00130 | 0.00951 | -0.9738 | -0.7196 | 0.4484 | 1.0639 | 0.910 | 1.1893 | |
| HCC70 | TNBC | Basal A | JNK-IN-5A | JNK | JNK | 12400.168 | uM | 2.95370 | 2.51350 | 0.0912 | 0.2769 | 5.0000 | 0.2111 | 0.8215 | 1.3275 | |
| HCC70 | TNBC | Basal A | JNK-IN-5A | JNK | JNK | 10873.144 | uM | 1.95480 | 1.79640 | 0.1497 | 0.1724 | 5.0000 | 0.2488 | 0.9531 | 1.2304 | |
| HCC70 | TNBC | Basal A | L-779450 | BRAF | MAPK | 12400.166 | uM | 31.81930 | 35.16630 | 0.4276 | -0.3236 | 4.9899 | 0.0529 | 0.9497 | 1.3827 | |
| HCC70 | TNBC | Basal A | L-779450 | BRAF | MAPK | 10873.149 | uM | 30.35740 | 33.85290 | 0.3478 | -0.3595 | 4.9710 | 0.0340 | 0.9589 | 1.2562 | |
| HCC70 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 7470.098 | uM | 13.47370 | 685.28030 | 0.3761 | -1.0000 | 0.2796 | 0.1868 | 0.6213 | 0.9387 | |
| HCC70 | TNBC | Basal A | LBH589 | HDAC | HDAC | 12400.167 | uM | 0.06833 | 0.10488 | -0.9417 | -0.9461 | 2.4791 | 0.8654 | 0.9991 | 1.2627 |