Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC38 | TNBC | Basal B | Dichloroacetate | PDK | PDK | 12617.176 | uM | inf | inf | 0.9362 | 0.9362 | 0.0000 | 0.0213 | 0.4389 | 1.5509 | |
| HCC38 | TNBC | Basal B | Disulfiram | Proteasome | Proteasome | 12617.174 | uM | 0.19518 | 0.18384 | -0.4690 | 0.1292 | 5.0000 | 0.3502 | 0.6974 | 1.5935 | |
| HCC38 | TNBC | Basal B | Docetaxel | TUBB | TUBB | 9469.002 | uM | 0.00225 | 0.00336 | -0.4790 | -0.4039 | 1.4778 | 0.8762 | 0.9825 | 1.1541 | |
| HCC38 | TNBC | Basal B | Docetaxel | TUBB | TUBB | 9453.002 | uM | 0.00155 | 0.00206 | -0.4437 | -0.4476 | 2.2476 | 0.9688 | 0.9960 | 1.2655 | |
| HCC38 | TNBC | Basal B | Doxorubicin | TOP2 | TOP | 10268.007 | uM | 0.00960 | 0.02970 | -0.8620 | -0.8465 | 0.8773 | 1.1436 | 0.9774 | 1.3306 | |
| HCC38 | TNBC | Basal B | Doxorubicin | TOP2 | TOP | 9469.121 | uM | 0.07201 | 0.12280 | -0.9874 | -0.8224 | 1.8222 | 0.9346 | 0.9923 | 1.1298 | |
| HCC38 | TNBC | Basal B | Doxorubicin | TOP2 | TOP | 9453.121 | uM | 0.05852 | 0.10936 | -0.9827 | -0.8591 | 1.5992 | 0.9647 | 0.9960 | 1.2860 | |
| HCC38 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 7854.017 | uM | 0.05337 | 0.09941 | -0.9916 | -0.8379 | 1.5823 | 1.0585 | 0.9869 | 1.3102 | |
| HCC38 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 9453.017 | uM | 0.11827 | 0.16758 | -0.9939 | -0.8612 | 2.8736 | 1.0040 | 0.9961 | 1.2279 | |
| HCC38 | TNBC | Basal B | Erlotinib | EGFR | ErbB | 7469.09 | uM | inf | 79.23380 | 0.8694 | 0.5898 | 4.4214 | -0.0137 | 0.6395 | 1.9867 | |
| HCC38 | TNBC | Basal B | Erlotinib | EGFR | ErbB | 7468.091 | uM | 228.39130 | 998.01190 | 0.7342 | -0.8078 | 0.6520 | 0.0317 | 0.8451 | 1.4852 | |
| HCC38 | TNBC | Basal B | Etoposide | TOP2 | TOP | 7469.074 | uM | 0.38626 | 0.67303 | -0.5694 | -0.5634 | 1.3590 | 0.7416 | 0.9984 | 1.9843 | |
| HCC38 | TNBC | Basal B | Etoposide | TOP2 | TOP | 7468.074 | uM | 0.26663 | 0.59974 | -0.8181 | -0.8151 | 1.1929 | 0.8984 | 0.9993 | 1.5027 | |
| HCC38 | TNBC | Basal B | Everolimus | MTOR | MTOR | 11850.156 | uM | 1.31550 | 16.71990 | -0.6644 | -1.0000 | 0.4321 | 0.3872 | 0.8145 | 1.8757 | |
| HCC38 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 7469.084 | uM | 0.32131 | 0.50105 | -0.8718 | -0.8424 | 2.2228 | 0.6426 | 0.9923 | 2.0377 | |
| HCC38 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 7468.085 | uM | 0.26531 | 0.41397 | -0.9590 | -0.9545 | 2.4002 | 0.6923 | 0.9965 | 1.4385 | |
| HCC38 | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 10578.137 | uM | inf | inf | 0.8466 | 0.8466 | 0.0000 | 0.0871 | -0.0040 | 1.8268 | |
| HCC38 | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 11850.161 | uM | 71.08970 | 332.26110 | 0.3872 | -1.0000 | 0.7125 | 0.1217 | 0.8924 | 2.0754 | |
| HCC38 | TNBC | Basal B | FTase Inhibitor I | Ftase | MAPK | 10578.142 | uM | inf | inf | 0.9333 | 0.9333 | 0.0000 | 0.0825 | 0.0000 | 1.8112 | |
| HCC38 | TNBC | Basal B | FTase Inhibitor I | Ftase | MAPK | 11850.154 | uM | inf | inf | 0.9670 | 0.9670 | 0.0000 | 0.0493 | 0.0000 | 1.9115 | |
| HCC38 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 9453.019 | uM | 48.74480 | 75.48140 | 0.7340 | -0.7561 | 2.1065 | 0.0452 | 0.7484 | 1.1486 | |
| HCC38 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 9469.024 | uM | 11.26850 | 10.34670 | 0.1735 | 0.1708 | 4.8959 | 0.0819 | 0.9220 | 1.0746 | |
| HCC38 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 9028.016 | uM | 28.53410 | 31.30160 | 0.2718 | -0.2724 | 4.6972 | 0.0586 | 0.9310 | 1.2348 | |
| HCC38 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 7854.016 | uM | 25.43790 | 31.12610 | -0.0924 | -0.8715 | 5.0000 | 0.0515 | 0.9793 | 0.9074 | |
| HCC38 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 9453.012 | uM | 0.01962 | 0.02148 | -0.4082 | -0.2047 | 3.7918 | 0.7809 | 0.9256 | 1.2055 |