Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC38 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 9469.024 | uM | 0.03412 | 0.04659 | -0.3587 | -0.2567 | 1.3304 | 0.7321 | 0.9715 | 1.0746 | |
| HCC38 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 9469.131 | uM | inf | inf | -0.7980 | -0.7980 | 0.0000 | 1.5023 | 0.0000 | 1.0627 | |
| HCC38 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 9469.011 | uM | 0.00436 | 0.00565 | -0.7427 | -0.6976 | 3.3673 | 1.3528 | 0.9958 | 1.1991 | |
| HCC38 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 10268.12 | uM | 0.00161 | 0.00201 | -0.9994 | -1.0000 | 5.0000 | 1.6132 | 0.9985 | 0.3272 | |
| HCC38 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 9453.011 | uM | 0.01981 | 0.02434 | -0.9070 | -0.9002 | 5.0000 | 1.2811 | 0.9987 | 0.7773 | |
| HCC38 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 9028.075 | uM | 0.00457 | 0.00564 | -0.9576 | -0.9350 | 5.0000 | 1.7932 | 0.9991 | 0.6011 | |
| HCC38 | TNBC | Basal B | Glycyl-H-1152 | ROCK2 | 10578.138 | uM | 0.98176 | 1.04630 | -0.3009 | -0.1252 | 3.5088 | 0.3289 | 0.9568 | 1.7866 | ||
| HCC38 | TNBC | Basal B | Glycyl-H-1152 | ROCK2 | 11850.16 | uM | 1.02930 | 1.4330 | -0.4893 | -0.4113 | 1.8144 | 0.4219 | 0.9947 | 1.8797 | ||
| HCC38 | TNBC | Basal B | GM6001 | MMP | MMP | 7468.096 | uM | inf | inf | 0.8683 | 0.8683 | 0.0000 | 0.0730 | 0.0495 | 1.5683 | |
| HCC38 | TNBC | Basal B | GSK1070916 | AURK | AURK | 9469.001 | uM | 0.52608 | 2.84380 | -0.9770 | -1.0000 | 0.6511 | 0.4475 | 0.9108 | 1.0202 | |
| HCC38 | TNBC | Basal B | GSK1070916 | AURK | AURK | 9453.001 | uM | 0.18090 | 1.87020 | -0.9029 | -1.0000 | 0.4703 | 0.5168 | 0.9195 | 1.2616 | |
| HCC38 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 7469.071 | uM | inf | 0.04020 | 0.8577 | 0.9105 | 1.2151 | 0.0450 | 0.6594 | 2.1768 | |
| HCC38 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 7469.09 | uM | inf | 1.07150 | 0.8294 | 0.8808 | 1.2881 | 0.0398 | 0.8008 | 1.9867 | |
| HCC38 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 7468.091 | uM | 7.45050 | 9.3610 | -0.9216 | -0.9225 | 4.5802 | 0.3972 | 0.9956 | 1.4852 | |
| HCC38 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 7469.098 | uM | 8.60510 | 12.52080 | -0.7962 | -0.8199 | 2.5881 | 0.2651 | 0.9966 | 2.0111 | |
| HCC38 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 9469.001 | uM | 0.02738 | 0.03084 | -0.7970 | -0.4074 | 5.0000 | 0.7421 | 0.9539 | 1.0202 | |
| HCC38 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 9453.001 | uM | 0.02992 | 0.03334 | -0.3514 | -0.2339 | 3.5495 | 0.6684 | 0.9929 | 1.2616 | |
| HCC38 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 9469.001 | uM | 0.03925 | 0.04818 | -0.5513 | -0.4037 | 2.8891 | 0.6974 | 0.9880 | 1.0202 | |
| HCC38 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 9453.001 | uM | 0.04334 | 0.05796 | -0.4788 | -0.3827 | 1.9551 | 0.6790 | 0.9943 | 1.2616 | |
| HCC38 | TNBC | Basal B | GW-5074 | CRAF | MAPK | 7468.088 | uM | inf | inf | 0.3292 | 0.3292 | 0.0000 | 0.2301 | 0.2064 | 0.5744 | |
| HCC38 | TNBC | Basal B | GW843682X | PLK | PLK | 10578.139 | uM | inf | inf | 0.9988 | 0.9988 | 0.0000 | -0.0137 | -0.1933 | 1.6434 | |
| HCC38 | TNBC | Basal B | Ibandronate | FDPS | 10578.143 | uM | 48.13940 | 86.92310 | -0.5253 | -0.5864 | 1.3132 | 0.3866 | 0.9924 | 1.6935 | ||
| HCC38 | TNBC | Basal B | Ibandronate | FDPS | 11850.143 | uM | 58.12590 | 78.37930 | -0.4564 | -0.4499 | 2.1468 | 0.3429 | 0.9952 | 2.1044 | ||
| HCC38 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 10578.139 | uM | 0.37040 | 0.28969 | 0.1037 | 0.3537 | 4.9999 | 0.2734 | 0.8067 | 1.6434 | |
| HCC38 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 11850.157 | uM | 0.34217 | 0.28211 | 0.0246 | 0.0967 | 1.1142 | 0.3900 | 0.9533 | 2.0943 |