Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC38 | TNBC | Basal B | IKK16 | IKK | NFKB | 7468.093 | uM | 3.10130 | 3.93350 | -0.9724 | -0.9753 | 4.5519 | 0.4375 | 0.9948 | 1.4007 | |
| HCC38 | TNBC | Basal B | IKK16 | IKK | NFKB | 10578.1 | uM | 3.41280 | 4.23020 | -0.9511 | -0.9525 | 4.9669 | 0.4114 | 0.9978 | 1.6202 | |
| HCC38 | TNBC | Basal B | IKK16 | IKK | NFKB | 10418.093 | uM | 2.8280 | 3.64580 | -0.9969 | -0.9995 | 4.3238 | 0.4160 | 0.9980 | 0.9872 | |
| HCC38 | TNBC | Basal B | Imatinib | ABL/KIT/PDGFR | nRTK | 7468.091 | uM | 28.77820 | 39.13170 | -0.9542 | -0.9566 | 3.4794 | 0.4170 | 0.9973 | 1.4852 | |
| HCC38 | TNBC | Basal B | Imatinib | ABL/KIT/PDGFR | nRTK | 7469.09 | uM | 31.10950 | 37.74430 | -0.8139 | -0.8145 | 5.0000 | 0.3409 | 0.9987 | 1.9867 | |
| HCC38 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 7469.067 | uM | 0.07733 | 1.16220 | -0.8905 | -1.0000 | 0.4054 | 0.5746 | 0.8759 | 2.0639 | |
| HCC38 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 7468.067 | uM | 0.03607 | 0.04789 | -0.9792 | -0.4267 | 2.1770 | 0.6782 | 0.9050 | 1.3847 | |
| HCC38 | TNBC | Basal B | Ixabepilone | TUBB | TUBB | 7469.095 | uM | 0.00310 | 0.00497 | -0.9048 | -0.5016 | 1.4776 | 1.0099 | 0.9446 | 1.8946 | |
| HCC38 | TNBC | Basal B | Ixabepilone | TUBB | TUBB | 10418.095 | uM | 0.00180 | 0.00302 | -0.9979 | -0.6317 | 1.5781 | 1.1635 | 0.950 | 1.1425 | |
| HCC38 | TNBC | Basal B | Ixabepilone | TUBB | TUBB | 7468.095 | uM | 0.00356 | 0.00561 | -0.9857 | -0.5908 | 1.7194 | 1.0633 | 0.9517 | 1.4474 | |
| HCC38 | TNBC | Basal B | JNK-IN-5A | JNK | JNK | 11850.144 | uM | inf | inf | -0.3875 | -0.3875 | 0.0000 | 0.2825 | 0.5730 | 1.9379 | |
| HCC38 | TNBC | Basal B | JNK-IN-5A | JNK | JNK | 10578.144 | uM | 1.14360 | 1.43410 | -0.2997 | -0.2616 | 1.8588 | 0.4742 | 0.9910 | 1.6376 | |
| HCC38 | TNBC | Basal B | L-779450 | BRAF | MAPK | 10578.137 | uM | inf | inf | 0.6868 | 0.6868 | 0.0000 | 0.0974 | 0.3820 | 1.8268 | |
| HCC38 | TNBC | Basal B | L-779450 | BRAF | MAPK | 11850.161 | uM | 16.610 | 26.65170 | -0.6253 | -1.0000 | 2.3234 | 0.1644 | 0.9876 | 2.0754 | |
| HCC38 | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 7469.098 | uM | inf | inf | 0.9936 | 0.9936 | 0.0000 | 0.0222 | 0.1591 | 2.0111 | |
| HCC38 | TNBC | Basal B | LBH589 | HDAC | HDAC | 11850.154 | uM | 0.03768 | 0.07313 | -0.8586 | -0.8644 | 1.5138 | 0.8966 | 0.9989 | 1.9115 | |
| HCC38 | TNBC | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 10578.142 | uM | 0.12314 | 0.46379 | -0.9049 | -0.8797 | 0.7654 | 0.7903 | 0.9811 | 1.8112 | |
| HCC38 | TNBC | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 11850.154 | uM | 0.06337 | 0.12325 | -0.8817 | -0.7524 | 1.3804 | 0.7578 | 0.9859 | 1.9115 | |
| HCC38 | TNBC | Basal B | Mebendazole | 12617.174 | uM | 0.35225 | 0.53461 | -0.3927 | -0.2560 | 0.9909 | 0.4554 | 0.9683 | 1.5935 | |||
| HCC38 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 7469.084 | uM | inf | inf | 0.8890 | 0.8890 | 0.0000 | 0.0716 | 0.0139 | 2.0377 | |
| HCC38 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 7468.085 | uM | inf | 0.11591 | 0.8106 | 0.8307 | 4.9561 | 0.1077 | 0.9157 | 1.4385 | |
| HCC38 | TNBC | Basal B | Methylglyoxal | 13635.184 | uM | inf | inf | -0.7403 | -0.7403 | 0.0000 | 0.4439 | 0.5429 | 1.5062 | |||
| HCC38 | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 14212.189 | uM | inf | inf | 0.4852 | 0.4852 | 0.0000 | 0.5240 | 0.4451 | 1.6254 | |
| HCC38 | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 14212.189 | uM | inf | inf | 0.4852 | 0.4852 | 0.0000 | 0.5240 | 0.4451 | 1.6254 | |
| HCC38 | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 10578.145 | uM | 0.2760 | 0.45953 | -0.9775 | -0.9583 | 2.0996 | 0.7930 | 0.9951 | 1.6766 |