Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC38 | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 10578.145 | uM | 0.2760 | 0.45953 | -0.9775 | -0.9583 | 2.0996 | 0.7930 | 0.9951 | 1.6766 | |
| HCC38 | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 14616.189 | uM | 0.24510 | 0.33574 | -0.9777 | -0.9730 | 3.4335 | 0.8398 | 0.9968 | 1.4258 | |
| HCC38 | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 14616.189 | uM | 0.24510 | 0.33574 | -0.9777 | -0.9730 | 3.4335 | 0.8398 | 0.9968 | 1.4258 | |
| HCC38 | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 11850.145 | uM | 0.18684 | 0.24135 | -0.7584 | -0.7476 | 3.5716 | 0.7743 | 0.9991 | 2.1492 | |
| HCC38 | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 11850.145 | uM | 0.18684 | 0.24135 | -0.7584 | -0.7476 | 3.5716 | 0.7743 | 0.9991 | 2.1492 | |
| HCC38 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 10578.135 | uM | 0.10019 | 0.18239 | -0.5216 | -0.5061 | 1.1672 | 0.7151 | 0.9903 | 1.7650 | |
| HCC38 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 11850.135 | uM | 0.02928 | 0.05418 | -0.6865 | -0.6534 | 1.3585 | 0.9345 | 0.9941 | 1.9060 | |
| HCC38 | TNBC | Basal B | Nelfinavir | 12617.174 | uM | 13.99550 | 18.38860 | -0.5913 | -0.7927 | 3.4795 | 0.1133 | 0.9986 | 1.5935 | |||
| HCC38 | TNBC | Basal B | Nilotinib | ABL | nRTK | 11850.145 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0017 | -0.0001 | 2.1492 | |
| HCC38 | TNBC | Basal B | Nilotinib | ABL | nRTK | 10578.145 | uM | 74.17850 | 26.03660 | 0.4519 | 0.4436 | 2.0847 | 0.1179 | 0.9504 | 1.6766 | |
| HCC38 | TNBC | Basal B | NSC 663284 | CDC25 | CDC | 10578.14 | uM | 2.19560 | 3.93220 | -0.9845 | -0.9440 | 1.8201 | 0.5926 | 0.9961 | 1.6718 | |
| HCC38 | TNBC | Basal B | NSC 663284 | CDC25 | CDC | 11850.159 | uM | 2.33660 | 4.17950 | -0.8493 | -0.8515 | 1.7100 | 0.5567 | 0.9968 | 1.9270 | |
| HCC38 | TNBC | Basal B | NU6102 | CDK1/2 | CDK | 11850.147 | uM | 11.04560 | 23.12730 | -0.6760 | -1.0000 | 1.4867 | 0.2513 | 0.9804 | 2.1087 | |
| HCC38 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 10418.066 | uM | 20.57240 | 58.9080 | -0.0794 | -1.0000 | 1.0443 | 0.1536 | 0.9555 | 1.1532 | |
| HCC38 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 7468.066 | uM | 19.68030 | 34.18440 | -0.5845 | -1.0000 | 1.9897 | 0.1867 | 0.9778 | 1.3940 | |
| HCC38 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 7469.066 | uM | 22.40 | 21.64890 | 0.0801 | 0.0762 | 4.8483 | 0.0758 | 0.9892 | 2.0057 | |
| HCC38 | TNBC | Basal B | Olomoucine II | CDK1 | CDK | 11850.147 | uM | 3.35060 | 5.31960 | -0.5182 | -0.5635 | 1.6326 | 0.4202 | 0.9947 | 2.1087 | |
| HCC38 | TNBC | Basal B | Omipalisib | PI3K | PI3K | 10418.087 | uM | 0.02066 | 0.08380 | -0.8268 | -0.8232 | 0.6949 | 0.8703 | 0.9860 | 1.1498 | |
| HCC38 | TNBC | Basal B | Omipalisib | PI3K | PI3K | 10578.087 | uM | 0.05466 | 0.14499 | -0.8799 | -0.8177 | 0.9932 | 0.7587 | 0.9953 | 1.3188 | |
| HCC38 | TNBC | Basal B | Omipalisib | PI3K | PI3K | 7468.086 | uM | 0.02614 | 0.07378 | -0.7918 | -0.7776 | 0.9042 | 0.8412 | 0.9990 | 1.2962 | |
| HCC38 | TNBC | Basal B | Oxaliplatin | DNA cross-linker | DNA cross-linker | 10268.12 | uM | inf | inf | -1.0000 | -1.0000 | 0.0000 | 1.2668 | 0.5308 | 0.3272 | |
| HCC38 | TNBC | Basal B | Oxaliplatin | DNA cross-linker | DNA cross-linker | 9028.075 | uM | 1.74280 | 5.86920 | -0.9728 | -1.0000 | 0.9048 | 0.7022 | 0.9921 | 0.6011 | |
| HCC38 | TNBC | Basal B | Oxaliplatin | DNA cross-linker | DNA cross-linker | 9469.011 | uM | 4.17480 | 16.25840 | -0.9375 | -1.0000 | 0.8081 | 0.5798 | 0.9953 | 1.1991 | |
| HCC38 | TNBC | Basal B | Oxaliplatin | DNA cross-linker | DNA cross-linker | 9453.011 | uM | 7.91820 | 17.01960 | -0.9837 | -1.0000 | 1.4357 | 0.5359 | 0.9966 | 0.7773 | |
| HCC38 | TNBC | Basal B | Oxamflatin | HDAC | HDAC | 11850.147 | uM | 0.19648 | 0.41806 | -0.7791 | -0.7901 | 1.2553 | 0.7279 | 0.9960 | 2.1087 |