Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC3153 | TNBC | Basal A | Ibandronate | FDPS | 10937.143 | uM | 76.74170 | 86.08140 | -0.1089 | -0.1059 | 1.6725 | 0.2383 | 0.9923 | 1.3133 | ||
| HCC3153 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 10577.139 | uM | inf | inf | 0.7835 | 0.7835 | 0.0000 | 0.0451 | 0.2207 | 0.9234 | |
| HCC3153 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 10937.151 | uM | inf | 0.18074 | 0.6444 | 0.6849 | 3.1243 | 0.1468 | 0.8890 | 1.5219 | |
| HCC3153 | TNBC | Basal A | IKK16 | IKK | NFKB | 7465.1 | uM | 2.88150 | 3.99290 | -0.9646 | -0.9784 | 3.3234 | 0.4962 | 0.980 | 1.2603 | |
| HCC3153 | TNBC | Basal A | IKK16 | IKK | NFKB | 10577.1 | uM | 9.01030 | 11.20710 | -0.9879 | -0.9882 | 4.9993 | 0.2835 | 0.9980 | 0.8774 | |
| HCC3153 | TNBC | Basal A | IKK16 | IKK | NFKB | 7466.093 | uM | 2.9670 | 3.71370 | -0.9887 | -0.9902 | 4.8649 | 0.4266 | 0.9987 | 0.8543 | |
| HCC3153 | TNBC | Basal A | Imatinib | ABL/KIT/PDGFR | nRTK | 7465.092 | uM | 27.12530 | 44.23040 | -0.9769 | -0.9968 | 2.2426 | 0.5071 | 0.9579 | 1.2055 | |
| HCC3153 | TNBC | Basal A | Imatinib | ABL/KIT/PDGFR | nRTK | 7467.091 | uM | 27.82050 | 39.93920 | -0.9764 | -0.9798 | 3.0007 | 0.4263 | 0.9973 | 1.2996 | |
| HCC3153 | TNBC | Basal A | Imatinib | ABL/KIT/PDGFR | nRTK | 7466.092 | uM | 30.23740 | 41.10640 | -0.9899 | -0.9905 | 3.5568 | 0.4036 | 0.9988 | 0.9158 | |
| HCC3153 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 7467.067 | uM | 0.02071 | 0.02955 | -0.9735 | -0.4581 | 1.8299 | 0.7674 | 0.9122 | 1.3252 | |
| HCC3153 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 7466.067 | uM | 0.03319 | 0.03912 | -0.9891 | -0.6378 | 4.9994 | 0.8533 | 0.9713 | 0.9457 | |
| HCC3153 | TNBC | Basal A | Ixabepilone | TUBB | TUBB | 7465.095 | uM | 0.00639 | 0.01097 | -0.9474 | -0.4667 | 1.2203 | 0.9133 | 0.8917 | 1.2754 | |
| HCC3153 | TNBC | Basal A | Ixabepilone | TUBB | TUBB | 7467.095 | uM | 0.0040 | 0.00623 | -0.9545 | -0.5226 | 1.6137 | 1.0115 | 0.9385 | 1.2671 | |
| HCC3153 | TNBC | Basal A | Ixabepilone | TUBB | TUBB | 7466.095 | uM | 0.01109 | 0.01588 | -0.9919 | -0.6670 | 2.3641 | 0.9758 | 0.9686 | 0.8699 | |
| HCC3153 | TNBC | Basal A | JNK-IN-5A | JNK | JNK | 10937.144 | uM | 2.08580 | 1.59690 | 0.5745 | 0.3685 | 5.0000 | 0.2219 | 0.6796 | 1.5466 | |
| HCC3153 | TNBC | Basal A | JNK-IN-5A | JNK | JNK | 10577.144 | uM | 1.51110 | 1.66060 | -0.2905 | -0.3013 | 5.0000 | 0.4344 | 0.9877 | 0.9534 | |
| HCC3153 | TNBC | Basal A | L-779450 | BRAF | MAPK | 10577.137 | uM | 128.91780 | 407.61850 | 0.8182 | -0.9196 | 0.9065 | 0.0143 | 0.7373 | 0.9653 | |
| HCC3153 | TNBC | Basal A | L-779450 | BRAF | MAPK | 10937.149 | uM | 45.2220 | 35.9980 | 0.7333 | 0.3402 | 4.9999 | -0.0142 | 0.8321 | 1.3519 | |
| HCC3153 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 7467.098 | uM | inf | inf | 0.9507 | 0.9507 | 0.0000 | -0.0070 | 0.1810 | 1.4178 | |
| HCC3153 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 7465.098 | uM | inf | inf | 0.7421 | 0.7421 | 0.0000 | 0.1459 | 0.2598 | 1.2188 | |
| HCC3153 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 7466.098 | uM | inf | inf | 0.6772 | 0.6772 | 0.0000 | 0.0999 | 0.3464 | 0.8226 | |
| HCC3153 | TNBC | Basal A | LBH589 | HDAC | HDAC | 10937.154 | uM | 0.29675 | 0.44798 | -0.5527 | -0.5092 | 1.7053 | 0.5085 | 0.9958 | 1.5291 | |
| HCC3153 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 10577.142 | uM | 6.5240 | 9.92430 | -0.9691 | -0.9764 | 2.5810 | 0.4740 | 0.9587 | 1.0584 | |
| HCC3153 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 10937.154 | uM | 7.62070 | 11.29650 | -0.9117 | -1.0000 | 2.7910 | 0.2041 | 0.9933 | 1.5291 | |
| HCC3153 | TNBC | Basal A | Mebendazole | 13733.174 | uM | 0.22612 | 8.73650 | -0.5068 | -1.0000 | 0.3006 | 0.5298 | 0.8956 | 0.5093 |