Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
HCC2185
TNBC
Luminal
 Epirubicin
TOP2
TOP
7848.017
uM
0.17714
0.50367
 -1.0000 -1.0000 1.0513 0.9005
0.9933
 0.3225
HCC2185
TNBC
Luminal
 Epirubicin
TOP2
TOP
7846.017
uM
0.09958
0.30622
 -1.0000 -1.0000 0.9780 0.9746
0.9944
 0.3403
HCC2185
TNBC
Luminal
 Epirubicin
TOP2
TOP
7849.017
uM
0.18204
0.44653
 -1.0000 -0.9957 1.2212 0.9147
0.9980
 0.3471
HCC2185
TNBC
Luminal
 Erlotinib
EGFR
ErbB
7462.092
uM
32.7310
501.43790
 0.4732 -1.0000 0.4026 0.1100
0.7912
 0.4336
HCC2185
TNBC
Luminal
 Erlotinib
EGFR
ErbB
7463.09
uM
17.06280
649.41540
 0.3770 -0.7200 0.2451 0.2397
0.8575
 0.5483
HCC2185
TNBC
Luminal
 Erlotinib
EGFR
ErbB
7464.09
uM
17.9310
13.2640
 0.3895 0.3893 5.0000 0.0779
0.9391
 0.4958
HCC2185
TNBC
Luminal
 Etoposide
TOP2
TOP
7463.074
uM
42.50860
61.23060
 -0.3217 -0.4060 1.6287 0.2813
0.8396
 0.4574
HCC2185
TNBC
Luminal
 Etoposide
TOP2
TOP
7462.074
uM
3.27960
50.73830
 -0.3695 -1.0000 0.4011 0.4522
0.9477
 0.6126
HCC2185
TNBC
Luminal
 Etoposide
TOP2
TOP
7464.074
uM
6.93160
44.65820
 -0.5404 -1.0000 0.5897 0.3827
0.9952
 0.5504
HCC2185
TNBC
Luminal
 Everolimus
MTOR
MTOR
10996.156
uM
0.00920
0.01796
 -0.9119 -0.4966 1.0311 0.9150
0.9257
 0.4283
HCC2185
TNBC
Luminal
 Everolimus
MTOR
MTOR
12192.164
uM
0.00675
0.01587
 -0.6082 -0.3431 0.6112 0.8399
0.9343
 0.5828
HCC2185
TNBC
Luminal
 Fascaplysin
CDK4
CDK
7463.084
uM
0.12852
0.28996
 -0.9997 -1.0000 1.3502 0.8359
0.9651
 0.7560
HCC2185
TNBC
Luminal
 Fascaplysin
CDK4
CDK
7462.085
uM
0.01916
0.07622
 -1.0000 -1.0000 0.7956 0.9867
0.9706
 0.3896
HCC2185
TNBC
Luminal
 Fascaplysin
CDK4
CDK
7464.084
uM
0.12235
0.24577
 -0.9958 -1.0000 1.5751 0.7922
0.9942
 0.8152
HCC2185
TNBC
Luminal
 FR180204
ERK1/2
MAPK
10996.149
uM
inf
inf
 0.9724 0.9724 0.0000 0.0208
0.0401
 0.4765
HCC2185
TNBC
Luminal
 FR180204
ERK1/2
MAPK
12192.161
uM
inf
inf
 0.8011 0.8011 0.0000 0.0270
0.5359
 0.5555
HCC2185
TNBC
Luminal
 FTase Inhibitor I
Ftase
MAPK
12192.154
uM
inf
inf
 0.9309 0.9309 0.0000 -0.0048
-0.0270
 0.5377
HCC2185
TNBC
Luminal
 FTase Inhibitor I
Ftase
MAPK
10996.154
uM
inf
inf
 0.7281 0.7281 0.0000 0.2218
0.0000
 0.5230
HCC2185
TNBC
Luminal
 Gefitinib
EGFR
ErbB
9420.132
uM
inf
inf
 0.4783 0.4783 0.0000 0.1427
0.1330
 0.3309
HCC2185
TNBC
Luminal
 Gefitinib
EGFR
ErbB
7848.016
uM
162.91990
51.17650
 0.6991 0.2901 0.7496 0.0336
0.7573
 0.4818
HCC2185
TNBC
Luminal
 Gefitinib
EGFR
ErbB
7845.016
uM
10.09720
20.57540
 -0.3643 -1.0000 1.5433 0.2562
0.7917
 0.4392
HCC2185
TNBC
Luminal
 Gefitinib
EGFR
ErbB
7846.016
uM
8.07560
13.51120
 -0.7529 -1.0000 2.1346 0.2060
0.9492
 0.3279
HCC2185
TNBC
Luminal
 Gefitinib
EGFR
ErbB
7849.016
uM
7.58790
17.96450
 -0.3800 -1.0000 1.2747 0.1672
0.9784
 0.3419
HCC2185
TNBC
Luminal
 Geldanamycin
HSP90
HSP90
9421.012
uM
0.01269
0.01626
 -0.6402 -0.5013 2.8041 1.0282
0.9879
 0.7153
HCC2185
TNBC
Luminal
 Geldanamycin
HSP90
HSP90
9420.012
uM
0.01386
0.01703
 -0.9643 -0.9044 5.0000 1.3001
0.9964
 0.3162