Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC2185 | TNBC | Luminal | Geldanamycin | HSP90 | HSP90 | 7849.04 | uM | 0.01717 | 0.02311 | -0.8205 | -0.7965 | 3.2059 | 1.1738 | 0.9991 | 0.5448 | |
| HCC2185 | TNBC | Luminal | Gemcitabine | DNA replication | DNA replication | 7849.011 | uM | 0.03116 | 0.02711 | -0.0746 | 0.1113 | 1.8071 | 0.5893 | 0.9120 | 0.5467 | |
| HCC2185 | TNBC | Luminal | Gemcitabine | DNA replication | DNA replication | 7848.011 | uM | 0.0180 | 0.02052 | -0.3401 | -0.1962 | 2.5228 | 0.8366 | 0.9645 | 0.3405 | |
| HCC2185 | TNBC | Luminal | Glycyl-H-1152 | ROCK2 | 12192.16 | uM | 3.80670 | 5.47010 | -0.1440 | -0.2253 | 1.0261 | 0.2659 | 0.9286 | 0.7363 | ||
| HCC2185 | TNBC | Luminal | Glycyl-H-1152 | ROCK2 | 10996.15 | uM | 1.21560 | 1.18510 | -0.0454 | 0.0596 | 4.9974 | 0.2437 | 0.9374 | 0.5092 | ||
| HCC2185 | TNBC | Luminal | GM6001 | MMP | MMP | 7462.096 | uM | 61.72120 | 2.01760 | 0.5261 | 0.4946 | 1.3210 | 0.1374 | 0.8240 | 0.3514 | |
| HCC2185 | TNBC | Luminal | GSK1070916 | AURK | AURK | 10263.001 | uM | 0.14569 | 3.45390 | -0.4750 | -1.0000 | 0.3470 | 0.5409 | 0.8338 | 0.3258 | |
| HCC2185 | TNBC | Luminal | GSK1070916 | AURK | AURK | 9420.001 | uM | 0.03883 | 0.83363 | -0.8630 | -1.0000 | 0.3583 | 0.6662 | 0.8579 | 0.3332 | |
| HCC2185 | TNBC | Luminal | GSK1070916 | AURK | AURK | 7848.001 | uM | 0.23168 | 2.21180 | -0.7395 | -1.0000 | 0.4869 | 0.5192 | 0.9120 | 0.4548 | |
| HCC2185 | TNBC | Luminal | GSK1070916 | AURK | AURK | 7849.001 | uM | 0.52517 | 4.12770 | -0.6199 | -1.0000 | 0.5329 | 0.4275 | 0.9620 | 0.5308 | |
| HCC2185 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 7463.09 | uM | 1.44440 | 1.19130 | 0.1441 | 0.3092 | 5.0000 | 0.2881 | 0.7928 | 0.5483 | |
| HCC2185 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 7464.09 | uM | 3.71070 | 2.26050 | 0.4991 | 0.4580 | 4.9967 | 0.1369 | 0.9536 | 0.4958 | |
| HCC2185 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 7464.098 | uM | 3.87580 | 5.42990 | -0.8170 | -0.8189 | 2.8768 | 0.4114 | 0.9821 | 0.6305 | |
| HCC2185 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 7463.098 | uM | 2.15060 | 3.89190 | -0.7990 | -0.8106 | 1.6245 | 0.4437 | 0.9828 | 0.4880 | |
| HCC2185 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 7464.071 | uM | 5.84430 | 6.71230 | -0.6484 | -0.4993 | 5.0000 | 0.3201 | 0.9839 | 0.5610 | |
| HCC2185 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 7463.07 | uM | 1.90560 | 3.65970 | -0.7268 | -0.7859 | 1.4474 | 0.4520 | 0.9858 | 0.5848 | |
| HCC2185 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 7462.092 | uM | 3.01680 | 4.84860 | -0.9803 | -0.9824 | 2.2905 | 0.3993 | 0.9952 | 0.4336 | |
| HCC2185 | TNBC | Luminal | GSK461364 | PLK1 | PLK | 7849.001 | uM | 0.00104 | 0.00115 | -0.9115 | -0.3518 | 5.0000 | 1.0464 | 0.8751 | 0.5308 | |
| HCC2185 | TNBC | Luminal | GSK461364 | PLK1 | PLK | 7848.001 | uM | 0.00690 | 0.01004 | -0.7963 | -0.4889 | 1.8144 | 0.9258 | 0.9490 | 0.4548 | |
| HCC2185 | TNBC | Luminal | GSK461364 | PLK1 | PLK | 9420.001 | uM | 0.00476 | 0.00675 | -0.6476 | -0.4560 | 1.8559 | 0.9447 | 0.9722 | 0.3332 | |
| HCC2185 | TNBC | Luminal | GSK461364 | PLK1 | PLK | 10263.001 | uM | 0.00423 | 0.00507 | -0.9767 | -0.7367 | 5.0000 | 1.1583 | 0.9733 | 0.3258 | |
| HCC2185 | TNBC | Luminal | GSK923295 | CENPE | Kinesin | 10263.001 | uM | 0.03162 | 0.03969 | -0.5522 | -0.6572 | 3.6909 | 0.9431 | 0.9385 | 0.3258 | |
| HCC2185 | TNBC | Luminal | GSK923295 | CENPE | Kinesin | 9420.001 | uM | 0.02009 | 0.02827 | -0.5226 | -0.5100 | 2.0574 | 0.8581 | 0.9770 | 0.3332 | |
| HCC2185 | TNBC | Luminal | GSK923295 | CENPE | Kinesin | 7849.001 | uM | 0.07833 | 0.08466 | -0.4193 | -0.2372 | 5.0000 | 0.5266 | 0.9775 | 0.5308 | |
| HCC2185 | TNBC | Luminal | GSK923295 | CENPE | Kinesin | 7848.001 | uM | 0.06638 | 0.07453 | -0.5258 | -0.3922 | 5.0000 | 0.6420 | 0.9828 | 0.4548 |