Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1954 | HER2amp | Basal A | Ixabepilone | TUBB | TUBB | 7454.095 | uM | 0.00705 | 0.01260 | -0.9680 | -0.8291 | 1.6820 | 1.1801 | 0.9687 | 1.1351 | |
| HCC1954 | HER2amp | Basal A | Ixabepilone | TUBB | TUBB | 7456.095 | uM | 0.00235 | 0.00394 | -0.8594 | -0.6722 | 1.6448 | 1.1831 | 0.9776 | 1.9589 | |
| HCC1954 | HER2amp | Basal A | JNK-IN-5A | JNK | JNK | 11055.144 | uM | 1.91790 | 35.50970 | -0.4376 | -1.0000 | 0.3764 | 0.3850 | 0.8799 | 1.6716 | |
| HCC1954 | HER2amp | Basal A | L-779450 | BRAF | MAPK | 11055.149 | uM | 41.56930 | 58.82530 | 0.6261 | -0.4580 | 1.8727 | 0.0443 | 0.9026 | 1.6723 | |
| HCC1954 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 7454.098 | uM | 1.90430 | 1.9880 | -0.0513 | -0.0570 | 2.5075 | 0.2563 | 0.9037 | 1.2964 | |
| HCC1954 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 7455.098 | uM | 2.10310 | 1.97490 | 0.1381 | 0.1349 | 5.0000 | 0.1826 | 0.9584 | 1.3433 | |
| HCC1954 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 7457.098 | uM | inf | 0.81217 | 0.5041 | 0.5572 | 5.0000 | 0.1031 | 0.970 | 1.8323 | |
| HCC1954 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 7456.098 | uM | 1.85750 | 1.70220 | 0.0955 | 0.0898 | 2.2684 | 0.1705 | 0.9968 | 1.7388 | |
| HCC1954 | HER2amp | Basal A | LBH589 | HDAC | HDAC | 11055.154 | uM | 0.40599 | 0.88107 | -0.7128 | -0.7280 | 1.1597 | 0.4868 | 0.9981 | 1.7768 | |
| HCC1954 | HER2amp | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 11055.154 | uM | 4.6460 | 8.86190 | -0.8120 | -1.0000 | 1.7013 | 0.2563 | 0.9887 | 1.7768 | |
| HCC1954 | HER2amp | Basal A | Mebendazole | 13546.174 | uM | 0.14538 | 0.29445 | -0.3581 | -0.3118 | 0.6867 | 0.5674 | 0.9294 | 1.2035 | |||
| HCC1954 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 7457.084 | uM | inf | 0.00498 | 0.4882 | 0.5245 | 5.0000 | 0.4044 | 0.8926 | 1.8520 | |
| HCC1954 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 7456.084 | uM | 0.00833 | 0.00813 | 0.0575 | 0.0585 | 5.0000 | 0.7666 | 0.9962 | 1.9822 | |
| HCC1954 | HER2amp | Basal A | Methylglyoxal | 13631.184 | uM | inf | inf | -0.9647 | -0.9647 | 0.0000 | 0.6967 | 0.4015 | 1.3577 | |||
| HCC1954 | HER2amp | Basal A | MG-132 | Proteasome | Proteasome | 14209.189 | uM | inf | inf | -0.0003 | -0.0003 | 0.0000 | 0.4983 | 0.5266 | 2.0117 | |
| HCC1954 | HER2amp | Basal A | MG-132 | Proteasome | Proteasome | 14209.189 | uM | inf | inf | -0.0003 | -0.0003 | 0.0000 | 0.4983 | 0.5266 | 2.0117 | |
| HCC1954 | HER2amp | Basal A | MG-132 | Proteasome | Proteasome | 11055.145 | uM | 0.16855 | 0.19434 | -0.6650 | -0.5188 | 5.0000 | 0.6705 | 0.9859 | 1.7616 | |
| HCC1954 | HER2amp | Basal A | MG-132 | Proteasome | Proteasome | 11055.145 | uM | 0.16855 | 0.19434 | -0.6650 | -0.5188 | 5.0000 | 0.6705 | 0.9859 | 1.7616 | |
| HCC1954 | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 11055.135 | uM | 4.68410 | 4.80780 | 0.0162 | -0.0189 | 1.4220 | 0.2284 | 0.9853 | 1.7110 | |
| HCC1954 | HER2amp | Basal A | Nelfinavir | 13546.174 | uM | 26.1870 | 68.05840 | 0.3886 | -0.9963 | 1.1477 | 0.0991 | 0.8446 | 1.2035 | |||
| HCC1954 | HER2amp | Basal A | Nilotinib | ABL | nRTK | 11055.145 | uM | inf | inf | 0.9791 | 0.9791 | 0.0000 | -0.0257 | -0.8188 | 1.7616 | |
| HCC1954 | HER2amp | Basal A | NSC 663284 | CDC25 | CDC | 11055.152 | uM | 6.71930 | 9.63070 | -0.8660 | -0.8750 | 2.8102 | 0.4028 | 0.9979 | 1.6647 | |
| HCC1954 | HER2amp | Basal A | NU6102 | CDK1/2 | CDK | 11055.147 | uM | 46.81440 | 86.16730 | 0.2318 | -0.9783 | 1.7768 | 0.0673 | 0.9812 | 1.6841 | |
| HCC1954 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 7454.066 | uM | 4.02720 | 999.92090 | 0.0140 | -0.9611 | 0.1945 | 0.3216 | 0.6650 | 1.2748 | |
| HCC1954 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 7457.066 | uM | 22.15920 | 45.62070 | -0.2953 | -1.0000 | 1.5214 | 0.2024 | 0.9088 | 1.6601 |