Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1954 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 7455.066 | uM | 14.89970 | 26.82020 | -0.7211 | -1.0000 | 1.8690 | 0.2408 | 0.9297 | 1.2976 | |
| HCC1954 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 10469.066 | uM | 19.19580 | 33.9010 | -0.5820 | -1.0000 | 1.9316 | 0.1846 | 0.9742 | 1.6299 | |
| HCC1954 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 7456.066 | uM | 17.57180 | 21.68360 | -0.7251 | -0.7385 | 4.3141 | 0.1284 | 0.9951 | 1.7785 | |
| HCC1954 | HER2amp | Basal A | Olomoucine II | CDK1 | CDK | 11055.147 | uM | 9.42270 | 10.1790 | -0.1445 | -0.1452 | 3.3033 | 0.2378 | 0.9913 | 1.6841 | |
| HCC1954 | HER2amp | Basal A | Omipalisib | PI3K | PI3K | 7454.087 | uM | 0.00381 | 0.01412 | -0.8082 | -0.8406 | 0.7530 | 1.1374 | 0.9564 | 1.2157 | |
| HCC1954 | HER2amp | Basal A | Omipalisib | PI3K | PI3K | 7455.087 | uM | 0.00452 | 0.01498 | -0.7511 | -0.7799 | 0.7849 | 1.0832 | 0.9714 | 1.2897 | |
| HCC1954 | HER2amp | Basal A | Omipalisib | PI3K | PI3K | 10469.087 | uM | 0.01496 | 0.02666 | -0.8807 | -0.7188 | 1.5421 | 0.9721 | 0.9834 | 1.5889 | |
| HCC1954 | HER2amp | Basal A | Omipalisib | PI3K | PI3K | 7456.086 | uM | 0.01717 | 0.02806 | -0.6850 | -0.5418 | 1.4942 | 0.8480 | 0.9887 | 1.8940 | |
| HCC1954 | HER2amp | Basal A | Oxaliplatin | DNA cross-linker | DNA cross-linker | 9386.011 | uM | 3.4180 | 28.5410 | -0.7075 | -1.0000 | 0.5177 | 0.5476 | 0.9779 | 1.5229 | |
| HCC1954 | HER2amp | Basal A | Oxamflatin | HDAC | HDAC | 11055.147 | uM | 1.93950 | 6.84940 | -0.8576 | -1.0000 | 0.8707 | 0.4123 | 0.9906 | 1.6841 | |
| HCC1954 | HER2amp | Basal A | PD 98059 | MEK | MAPK | 11055.152 | uM | inf | 14.73220 | 0.7941 | 0.7936 | 4.8318 | 0.0077 | 0.8678 | 1.6647 | |
| HCC1954 | HER2amp | Basal A | PD173074 | FGFR1/3 | RTK | 7454.093 | uM | 6.96930 | 10.61220 | -0.9082 | -1.0000 | 2.6127 | 0.2961 | 0.9308 | 1.3347 | |
| HCC1954 | HER2amp | Basal A | PD173074 | FGFR1/3 | RTK | 10469.1 | uM | 13.60020 | 21.24230 | -0.8972 | -1.0000 | 2.4637 | 0.2076 | 0.9920 | 1.5717 | |
| HCC1954 | HER2amp | Basal A | PD173074 | FGFR1/3 | RTK | 7455.093 | uM | 8.3870 | 16.49190 | -0.5182 | -1.0000 | 1.6247 | 0.1314 | 0.9962 | 1.7255 | |
| HCC1954 | HER2amp | Basal A | PD184352 | MEK | MAPK | 11055.155 | uM | 23.75260 | 483.87240 | 0.4233 | -1.0000 | 0.3645 | 0.1483 | 0.9484 | 1.7439 | |
| HCC1954 | HER2amp | Basal A | PD184352 | MEK | MAPK | 11055.155 | uM | 23.75260 | 483.87240 | 0.4233 | -1.0000 | 0.3645 | 0.1483 | 0.9484 | 1.7439 | |
| HCC1954 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7457.094 | uM | inf | inf | 0.8077 | 0.8077 | 0.0000 | 0.2414 | 0.0000 | 1.8462 | |
| HCC1954 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7455.095 | uM | inf | inf | -0.6708 | -0.6708 | 0.0000 | 0.3794 | 0.1820 | 1.8461 | |
| HCC1954 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7454.095 | uM | inf | inf | 0.7171 | 0.7171 | 0.0000 | 0.1308 | 0.4162 | 1.1351 | |
| HCC1954 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7456.095 | uM | 0.31496 | 0.15636 | 0.3219 | 0.3530 | 1.7478 | 0.5024 | 0.9703 | 1.9589 | |
| HCC1954 | HER2amp | Basal A | PS-1145 | IKK | NFKB | 7454.065 | uM | inf | inf | 0.7779 | 0.7779 | 0.0000 | 0.1159 | 0.0469 | 1.0489 | |
| HCC1954 | HER2amp | Basal A | PS-1145 | IKK | NFKB | 7457.065 | uM | inf | inf | 0.8494 | 0.8494 | 0.0000 | 0.0471 | 0.0632 | 1.5870 | |
| HCC1954 | HER2amp | Basal A | PS-1145 | IKK | NFKB | 7456.065 | uM | inf | 999.90580 | 0.6448 | 0.3898 | 0.3762 | 0.1040 | 0.7152 | 1.9899 | |
| HCC1954 | HER2amp | Basal A | PS-1145 | IKK | NFKB | 7455.065 | uM | inf | 217.63220 | 0.6989 | 0.6976 | 2.5631 | 0.0690 | 0.9103 | 1.7441 | |
| HCC1954 | HER2amp | Basal A | Purvalanol A | CDK1 | CDK | 7456.067 | uM | inf | inf | 0.6461 | 0.6461 | 0.0000 | 0.0807 | 0.4257 | 1.8797 |