Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC2185 | TNBC | Luminal | GW-5074 | CRAF | MAPK | 7462.088 | uM | 6.97180 | 6.24640 | 0.2115 | 0.2113 | 5.0000 | 0.1969 | 0.6479 | 0.3753 | |
| HCC2185 | TNBC | Luminal | Ibandronate | FDPS | 12192.143 | uM | 20.79370 | 31.71940 | -0.5923 | -0.5640 | 1.7884 | 0.4724 | 0.9749 | 0.5995 | ||
| HCC2185 | TNBC | Luminal | Ibandronate | FDPS | 10996.143 | uM | 5.57070 | 12.55950 | -0.8193 | -0.8147 | 1.1892 | 0.6554 | 0.9960 | 0.3034 | ||
| HCC2185 | TNBC | Luminal | ICRF-193 | TOP2 | TOP | 12192.157 | uM | 2.01480 | 0.95996 | 0.1540 | 0.2428 | 0.8966 | 0.2393 | 0.8565 | 0.5774 | |
| HCC2185 | TNBC | Luminal | ICRF-193 | TOP2 | TOP | 10996.151 | uM | 1.15320 | 3.17570 | 0.1708 | -0.2225 | 0.3634 | 0.3258 | 0.9012 | 0.4801 | |
| HCC2185 | TNBC | Luminal | IKK16 | IKK | NFKB | 7462.093 | uM | 5.03990 | 6.27840 | -0.9999 | -0.9999 | 4.9995 | 0.3765 | 0.9968 | 0.4426 | |
| HCC2185 | TNBC | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 7462.092 | uM | 12.46660 | 24.6620 | -1.0000 | -1.0000 | 1.6104 | 0.6547 | 0.8421 | 0.4336 | |
| HCC2185 | TNBC | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 7463.09 | uM | 11.45740 | 23.99340 | -0.9999 | -1.0000 | 1.4863 | 0.6130 | 0.9575 | 0.5483 | |
| HCC2185 | TNBC | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 7464.09 | uM | 12.9950 | 24.55260 | -0.9999 | -1.0000 | 1.7267 | 0.5057 | 0.9885 | 0.4958 | |
| HCC2185 | TNBC | Luminal | Ispinesib | KSP | Kinesin | 7463.067 | uM | 0.04434 | 0.82899 | -1.0000 | -1.0000 | 0.3752 | 0.6146 | 0.8190 | 0.6688 | |
| HCC2185 | TNBC | Luminal | Ispinesib | KSP | Kinesin | 7464.067 | uM | 0.03457 | 0.03859 | -0.9989 | -0.3675 | 5.0000 | 0.6811 | 0.8829 | 0.7308 | |
| HCC2185 | TNBC | Luminal | Ispinesib | KSP | Kinesin | 7462.067 | uM | 0.02670 | 0.03406 | -0.9999 | -0.7804 | 3.8619 | 0.9439 | 0.9880 | 0.4873 | |
| HCC2185 | TNBC | Luminal | Ixabepilone | TUBB | TUBB | 7463.094 | uM | inf | inf | -0.9995 | -0.9995 | 0.0000 | 0.6783 | 0.1192 | 0.6482 | |
| HCC2185 | TNBC | Luminal | Ixabepilone | TUBB | TUBB | 7464.095 | uM | inf | inf | -0.9996 | -0.9996 | 0.0000 | 0.6542 | 0.4315 | 0.5464 | |
| HCC2185 | TNBC | Luminal | Ixabepilone | TUBB | TUBB | 7462.095 | uM | inf | inf | -1.0000 | -1.0000 | 0.0000 | 0.8696 | 0.5735 | 0.3840 | |
| HCC2185 | TNBC | Luminal | JNK-IN-5A | JNK | JNK | 10996.144 | uM | inf | inf | 0.3659 | 0.3659 | 0.0000 | 0.2133 | 0.3780 | 0.5116 | |
| HCC2185 | TNBC | Luminal | JNK-IN-5A | JNK | JNK | 12192.144 | uM | inf | inf | -0.1105 | -0.1105 | 0.0000 | 0.2418 | 0.4283 | 0.5798 | |
| HCC2185 | TNBC | Luminal | L-779450 | BRAF | MAPK | 10996.149 | uM | inf | inf | 0.6160 | 0.6160 | 0.0000 | 0.0694 | 0.4759 | 0.4765 | |
| HCC2185 | TNBC | Luminal | L-779450 | BRAF | MAPK | 12192.161 | uM | 37.07840 | 45.72450 | -0.1748 | -0.9259 | 5.0000 | 0.0379 | 0.9882 | 0.5555 | |
| HCC2185 | TNBC | Luminal | Lapatinib | EGFR/HER2 | ErbB | 7463.098 | uM | inf | inf | 0.6423 | 0.6423 | 0.0000 | 0.1347 | 0.0715 | 0.4880 | |
| HCC2185 | TNBC | Luminal | Lapatinib | EGFR/HER2 | ErbB | 7464.098 | uM | inf | inf | 0.9208 | 0.9208 | 0.0000 | 0.0740 | 0.2911 | 0.6305 | |
| HCC2185 | TNBC | Luminal | LBH589 | HDAC | HDAC | 12192.154 | uM | 0.06005 | 0.08678 | -0.9991 | -0.9983 | 2.9808 | 0.9047 | 0.9966 | 0.5377 | |
| HCC2185 | TNBC | Luminal | LBH589 | HDAC | HDAC | 10996.154 | uM | 0.05942 | 0.08509 | -0.9993 | -0.9983 | 3.0573 | 0.9216 | 0.9981 | 0.5230 | |
| HCC2185 | TNBC | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 10996.154 | uM | 1.84070 | 3.0290 | -0.9926 | -1.0000 | 2.2056 | 0.3945 | 0.9876 | 0.5230 | |
| HCC2185 | TNBC | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 12192.154 | uM | 3.64420 | 4.87380 | -0.9731 | -0.9746 | 3.7200 | 0.3421 | 0.9891 | 0.5377 |