Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
HCC2185
TNBC
Luminal
 Methotrexate
DHFR
Metabolism
7463.084
uM
inf
inf
 0.8941 0.8941 0.0000 0.0497
0.0064
 0.7560
HCC2185
TNBC
Luminal
 Methotrexate
DHFR
Metabolism
7462.085
uM
inf
inf
 0.9501 0.9501 0.0000 0.0232
0.0502
 0.3896
HCC2185
TNBC
Luminal
 Methotrexate
DHFR
Metabolism
7464.084
uM
inf
inf
 0.8968 0.8968 0.0000 0.0087
0.3771
 0.8152
HCC2185
TNBC
Luminal
 MG-132
Proteasome
Proteasome
12192.145
uM
0.22335
0.27793
 -0.9962 -0.9917 5.0000 0.8977
0.9920
 0.4175
HCC2185
TNBC
Luminal
 MG-132
Proteasome
Proteasome
12192.145
uM
0.22335
0.27793
 -0.9962 -0.9917 5.0000 0.8977
0.9920
 0.4175
HCC2185
TNBC
Luminal
 MG-132
Proteasome
Proteasome
10996.145
uM
0.11945
0.18178
 -0.9872 -0.9740 2.5746 0.9429
0.9922
 0.5765
HCC2185
TNBC
Luminal
 MG-132
Proteasome
Proteasome
10996.145
uM
0.11945
0.18178
 -0.9872 -0.9740 2.5746 0.9429
0.9922
 0.5765
HCC2185
TNBC
Luminal
 Pevonedistat
NAE1
NAE1
12192.135
uM
0.34674
0.29928
 0.1391 0.1958 3.3756 0.3392
0.9724
 0.6212
HCC2185
TNBC
Luminal
 Nilotinib
ABL
nRTK
12192.145
uM
inf
inf
 1.0500 1.0500 0.0000 -0.0217
-0.1880
 0.4175
HCC2185
TNBC
Luminal
 Nilotinib
ABL
nRTK
10996.145
uM
inf
inf
 1.0142 1.0142 0.0000 0.0557
0.1140
 0.5765
HCC2185
TNBC
Luminal
 NSC 663284
CDC25
CDC
12192.159
uM
0.70235
1.56340
 -0.9933 -1.0000 1.3729 0.8181
0.9485
 0.8215
HCC2185
TNBC
Luminal
 NSC 663284
CDC25
CDC
10996.152
uM
1.2820
1.86290
 -0.9990 -1.0000 2.9395 0.7956
0.9707
 0.6343
HCC2185
TNBC
Luminal
 NU6102
CDK1/2
CDK
12192.147
uM
13.59390
15.49080
 -0.4596 -0.4606 4.9981 0.2091
0.9463
 0.5645
HCC2185
TNBC
Luminal
 NU6102
CDK1/2
CDK
10996.147
uM
15.09450
18.51290
 -0.8817 -0.8849 4.9904 0.1658
0.9858
 0.6261
HCC2185
TNBC
Luminal
 Nutlin 3a
MDM2
MDM2
7462.066
uM
8.54430
33.80710
 -0.3303 -1.0000 0.7988 0.2799
0.8760
 0.5644
HCC2185
TNBC
Luminal
 Nutlin 3a
MDM2
MDM2
7463.066
uM
18.58160
34.94620
 -0.5185 -1.0000 1.7393 0.1857
0.9692
 0.5542
HCC2185
TNBC
Luminal
 Nutlin 3a
MDM2
MDM2
7464.066
uM
16.78920
19.00840
 -0.4141 -0.4172 4.8872 0.0865
0.9926
 0.6384
HCC2185
TNBC
Luminal
 Olomoucine II
CDK1
CDK
10996.147
uM
7.10020
9.27980
 -0.4136 -0.4144 2.2550 0.2836
0.9901
 0.6261
HCC2185
TNBC
Luminal
 Olomoucine II
CDK1
CDK
12192.147
uM
6.84470
10.80660
 -0.7080 -0.7178 1.9493 0.3248
0.9936
 0.5645
HCC2185
TNBC
Luminal
 Oxaliplatin
DNA cross-linker
DNA cross-linker
7848.011
uM
3.65840
8.42860
 -1.0000 -1.0000 1.3163 0.6851
0.9953
 0.3405
HCC2185
TNBC
Luminal
 Oxaliplatin
DNA cross-linker
DNA cross-linker
9421.021
uM
3.32830
5.08560
 -1.0000 -0.9677 2.5400 0.7050
0.9975
 0.3726
HCC2185
TNBC
Luminal
 Oxaliplatin
DNA cross-linker
DNA cross-linker
7849.011
uM
4.30770
11.64210
 -0.9997 -1.0000 1.1050 0.6329
0.9992
 0.5467
HCC2185
TNBC
Luminal
 Oxamflatin
HDAC
HDAC
12192.147
uM
0.20617
0.60029
 -0.9989 -1.0000 1.0280 0.7732
0.9727
 0.5645
HCC2185
TNBC
Luminal
 Oxamflatin
HDAC
HDAC
10996.147
uM
0.40416
0.86890
 -0.9978 -1.0000 1.4353 0.7304
0.990
 0.6261
HCC2185
TNBC
Luminal
 PD 98059
MEK
MAPK
10996.152
uM
29.55780
486.1940
 0.3552 -1.0000 0.3923 0.1799
0.5975
 0.6343