Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC2185 | TNBC | Luminal | PD 98059 | MEK | MAPK | 12192.159 | uM | 1.4270 | 999.99990 | 0.1594 | -0.6247 | 0.1237 | 0.4211 | 0.6547 | 0.8215 | |
| HCC2185 | TNBC | Luminal | PD173074 | FGFR1/3 | RTK | 7462.093 | uM | 26.43830 | 32.46810 | -0.0083 | -0.8967 | 5.0000 | 0.0841 | 0.9360 | 0.4426 | |
| HCC2185 | TNBC | Luminal | PD184352 | MEK | MAPK | 10996.155 | uM | inf | inf | 0.8210 | 0.8210 | 0.0000 | 0.1837 | 0.0000 | 0.6934 | |
| HCC2185 | TNBC | Luminal | PD184352 | MEK | MAPK | 10996.155 | uM | inf | inf | 0.8210 | 0.8210 | 0.0000 | 0.1837 | 0.0000 | 0.6934 | |
| HCC2185 | TNBC | Luminal | PD184352 | MEK | MAPK | 12192.155 | uM | inf | inf | 0.7159 | 0.7159 | 0.0000 | 0.2130 | 0.0390 | 0.7451 | |
| HCC2185 | TNBC | Luminal | PD184352 | MEK | MAPK | 12192.155 | uM | inf | inf | 0.7159 | 0.7159 | 0.0000 | 0.2130 | 0.0390 | 0.7451 | |
| HCC2185 | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7464.095 | uM | inf | inf | 0.9059 | 0.9059 | 0.0000 | -0.0281 | -0.2886 | 0.5464 | |
| HCC2185 | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7462.095 | uM | inf | inf | 0.6298 | 0.6298 | 0.0000 | 0.0764 | 0.3441 | 0.3840 | |
| HCC2185 | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7463.094 | uM | inf | inf | 0.9058 | 0.9058 | 0.0000 | 0.0673 | 0.4936 | 0.6482 | |
| HCC2185 | TNBC | Luminal | PS-1145 | IKK | NFKB | 7464.065 | uM | inf | inf | 0.9611 | 0.9611 | 0.0000 | -0.0098 | -0.0695 | 0.7107 | |
| HCC2185 | TNBC | Luminal | PS-1145 | IKK | NFKB | 7463.065 | uM | inf | 35.55020 | 0.7381 | 0.7589 | 4.9874 | 0.0873 | 0.7220 | 0.5226 | |
| HCC2185 | TNBC | Luminal | PS-1145 | IKK | NFKB | 7462.065 | uM | inf | 12.12690 | 0.5787 | 0.6650 | 4.9993 | 0.1530 | 0.7936 | 0.3950 | |
| HCC2185 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 7462.067 | uM | inf | inf | 0.9338 | 0.9338 | 0.0000 | -0.0238 | -0.3817 | 0.4873 | |
| HCC2185 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 7463.067 | uM | 32.99550 | 17.88630 | 0.3072 | 0.2671 | 1.2477 | 0.1630 | 0.9290 | 0.6688 | |
| HCC2185 | TNBC | Luminal | Purvalanol A | CDK1 | CDK | 7464.067 | uM | 17.06480 | 19.38990 | -0.3169 | -0.3172 | 3.8462 | 0.2049 | 0.9955 | 0.7308 | |
| HCC2185 | TNBC | Luminal | QNZ | NFkB | NFKB | 7462.096 | uM | 0.00116 | 0.00255 | -0.6368 | -0.6418 | 1.0495 | 1.2048 | 0.9957 | 0.3514 | |
| HCC2185 | TNBC | Luminal | Ribavirin | 15306.211 | uM | inf | inf | 0.9179 | 0.9179 | 0.0000 | 0.0789 | 0.0000 | 0.4935 | |||
| HCC2185 | TNBC | Luminal | SB-3CT | MMP2/9 | MMP | 10996.144 | uM | inf | inf | 0.4725 | 0.4725 | 0.0000 | 0.1714 | 0.4081 | 0.5116 | |
| HCC2185 | TNBC | Luminal | SB-3CT | MMP2/9 | MMP | 12192.144 | uM | inf | inf | 0.2245 | 0.2245 | 0.0000 | 0.2059 | 0.5237 | 0.5798 | |
| HCC2185 | TNBC | Luminal | Selumetinib | MEK | MAPK | 12192.155 | uM | inf | inf | 0.8352 | 0.8352 | 0.0000 | 0.1087 | -0.0684 | 0.7451 | |
| HCC2185 | TNBC | Luminal | Selumetinib | MEK | MAPK | 10996.155 | uM | inf | inf | 0.9728 | 0.9728 | 0.0000 | 0.0875 | 0.0658 | 0.6934 | |
| HCC2185 | TNBC | Luminal | Sigma A6730 | AKT | AKT | 10996.153 | uM | 0.80696 | 1.86130 | -0.9987 | -0.9947 | 1.3103 | 0.6148 | 0.9761 | 0.3186 | |
| HCC2185 | TNBC | Luminal | Sigma A6730 | AKT | AKT | 12192.158 | uM | 2.37830 | 7.77320 | -0.7569 | -1.0000 | 0.9276 | 0.3892 | 0.9796 | 0.6680 | |
| HCC2185 | TNBC | Luminal | Sirolimus | MTOR | MTOR | 7463.068 | uM | 0.00019 | 0.00017 | -0.0655 | 0.0169 | 0.3266 | 0.8520 | 0.8086 | 0.5887 | |
| HCC2185 | TNBC | Luminal | Sirolimus | MTOR | MTOR | 7845.068 | uM | 0.00087 | 0.00157 | -0.5451 | -0.3982 | 0.9850 | 1.2168 | 0.9289 | 0.3849 |