Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1954 | HER2amp | Basal A | Trametinib | MEK | MAPK | 7839.05 | uM | 0.76028 | 0.02032 | 0.4491 | 0.4606 | 0.7011 | 0.2914 | 0.8467 | 1.7470 | |
| HCC1954 | HER2amp | Basal A | Trametinib | MEK | MAPK | 7837.05 | uM | 0.44063 | 0.82438 | 0.1324 | -0.1036 | 0.3007 | 0.3347 | 0.8467 | 1.7172 | |
| HCC1954 | HER2amp | Basal A | Trametinib | MEK | MAPK | 7836.05 | uM | 10.17870 | 0.06618 | 0.4809 | 0.4549 | 0.4775 | 0.2333 | 0.9168 | 1.4789 | |
| HCC1954 | HER2amp | Basal A | Trastuzumab | HER2 | ErbB | 9386.026 | uM | inf | inf | 0.7531 | 0.7531 | 0.0000 | 0.0956 | 0.4287 | 1.5583 | |
| HCC1954 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 7454.065 | uM | 5.09770 | 10.7180 | -0.9285 | -0.9407 | 1.4241 | 0.9814 | 0.9776 | 1.0489 | |
| HCC1954 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 7457.065 | uM | 12.18310 | 19.1790 | -0.8143 | -0.8059 | 2.1157 | 0.8296 | 0.9867 | 1.5870 | |
| HCC1954 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 7456.065 | uM | 14.09150 | 21.50220 | -0.7406 | -0.7039 | 2.0793 | 0.7421 | 0.9930 | 1.9899 | |
| HCC1954 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 7455.065 | uM | 9.45090 | 17.88690 | -0.8283 | -0.8207 | 1.5225 | 0.8139 | 0.9974 | 1.7441 | |
| HCC1954 | HER2amp | Basal A | Triciribine | AKT | AKT | 7457.074 | uM | 4.74480 | 411.13290 | 0.2414 | -1.0000 | 0.2462 | 0.2607 | 0.8981 | 1.6514 | |
| HCC1954 | HER2amp | Basal A | Triciribine | AKT | AKT | 7456.074 | uM | 29.61170 | 12.73430 | 0.4776 | 0.1603 | 0.4579 | 0.1316 | 0.9387 | 1.9647 | |
| HCC1954 | HER2amp | Basal A | Valproic acid | HDAC | HDAC | 11055.143 | uM | 979.25140 | 1000.00000 | -0.4180 | -0.0147 | 1.3812 | 0.1342 | 0.7735 | 1.7215 | |
| HCC1954 | HER2amp | Basal A | Vinorelbine | TUBB | TUBB | 7835.018 | uM | inf | inf | -0.9999 | -0.9999 | 0.0000 | 0.8246 | 0.1320 | 0.5326 | |
| HCC1954 | HER2amp | Basal A | Vinorelbine | TUBB | TUBB | 7837.042 | uM | 0.00015 | 0.00026 | -0.8248 | -0.4139 | 1.1755 | 1.2659 | 0.6601 | 1.6916 | |
| HCC1954 | HER2amp | Basal A | Vinorelbine | TUBB | TUBB | 7836.018 | uM | 0.00486 | 0.00632 | -0.9706 | -0.5857 | 2.9407 | 1.1119 | 0.910 | 1.0819 | |
| HCC1954 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 7454.065 | uM | 60.67030 | 165.01340 | -0.9581 | -0.9307 | 1.0507 | 0.7384 | 0.9727 | 1.0489 | |
| HCC1954 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 7456.065 | uM | 193.73430 | 551.59350 | -0.6044 | -0.7267 | 0.8577 | 0.5017 | 0.9940 | 1.9899 | |
| HCC1954 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 7457.065 | uM | 122.02790 | 348.13120 | -0.8547 | -0.8981 | 0.9809 | 0.5821 | 0.9942 | 1.5870 | |
| HCC1954 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 7455.065 | uM | 127.46540 | 496.06610 | -0.8226 | -0.9546 | 0.7859 | 0.5688 | 0.9985 | 1.7441 | |
| HCC1954 | HER2amp | Basal A | XRP44X | ELK3 | MAPK | 11055.151 | uM | 0.41139 | 0.48892 | -0.3275 | -0.2602 | 2.4266 | 0.5925 | 0.9720 | 1.8913 | |
| HCC1954 | HER2amp | Basal A | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14209.189 | uM | 0.61096 | 0.73818 | -0.7799 | -0.7874 | 5.0000 | 0.6227 | 0.9972 | 2.0117 | |
| HCC1954 | HER2amp | Basal A | ZM-447439 | AURK | AURK | 11055.15 | uM | inf | 9.430 | 0.6980 | 0.6805 | 2.2535 | 0.0021 | 0.8973 | 1.6412 | |
| HCC202 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 7840.016 | uM | inf | 0.00782 | 0.4780 | 0.5240 | 0.2269 | 0.3228 | 0.5803 | 0.4918 | ||
| HCC202 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 7841.016 | uM | 11.58790 | 12.32220 | -0.7397 | -0.1789 | 4.9785 | 0.2698 | 0.7517 | 0.4493 | ||
| HCC202 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 9402.037 | uM | 0.00449 | 0.02109 | -1.0000 | -0.9126 | 0.6718 | 1.2542 | 0.9270 | 0.3763 | |
| HCC202 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 7844.037 | uM | 0.02203 | 0.03608 | -0.9196 | -0.8023 | 1.9395 | 1.1506 | 0.9601 | 0.3471 |