Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1954 | HER2amp | Basal A | Purvalanol A | CDK1 | CDK | 7457.067 | uM | 62.54340 | 34.77620 | 0.3851 | 0.3674 | 2.2617 | 0.1125 | 0.9426 | 1.8574 | |
| HCC1954 | HER2amp | Basal A | Ribavirin | 15389.211 | uM | inf | 20.14420 | 0.7050 | 0.5845 | 0.9824 | 0.0380 | 0.9271 | 1.6724 | |||
| HCC1954 | HER2amp | Basal A | SB-3CT | MMP2/9 | MMP | 11055.144 | uM | inf | inf | 0.7776 | 0.7776 | 0.0000 | 0.0714 | 0.3204 | 1.6716 | |
| HCC1954 | HER2amp | Basal A | Selumetinib | MEK | MAPK | 11055.155 | uM | 3.91320 | 0.34906 | 0.4005 | 0.4009 | 0.6697 | 0.2271 | 0.9697 | 1.7439 | |
| HCC1954 | HER2amp | Basal A | Sigma A6730 | AKT | AKT | 11055.158 | uM | 7.97430 | 12.75210 | -0.8455 | -0.8951 | 2.1857 | 0.2653 | 0.9979 | 1.6948 | |
| HCC1954 | HER2amp | Basal A | Sirolimus | MTOR | MTOR | 7836.068 | uM | 0.01049 | 64.25020 | -0.2064 | -1.0000 | 0.1260 | 0.6818 | 0.8203 | 1.6317 | |
| HCC1954 | HER2amp | Basal A | Sirolimus | MTOR | MTOR | 7457.068 | uM | 0.00947 | 0.00243 | 0.0346 | 0.2078 | 0.3952 | 0.6269 | 0.8210 | 1.7951 | |
| HCC1954 | HER2amp | Basal A | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7457.084 | uM | inf | inf | -0.2321 | -0.2321 | 0.0000 | 0.2249 | 0.4456 | 1.8520 | |
| HCC1954 | HER2amp | Basal A | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7456.084 | uM | 2207.62450 | 1000.00000 | 0.5342 | 0.1545 | 0.4667 | 0.1151 | 0.8150 | 1.9822 | |
| HCC1954 | HER2amp | Basal A | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7456.067 | uM | inf | inf | -0.8302 | -0.8302 | 0.0000 | 0.3266 | 0.4204 | 1.8797 | |
| HCC1954 | HER2amp | Basal A | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7457.067 | uM | 7.33370 | 11.40410 | -0.9493 | -0.9574 | 2.4231 | 0.4256 | 0.9978 | 1.8574 | |
| HCC1954 | HER2amp | Basal A | Taxol | TUBB | TUBB | 7837.002 | uM | 0.01515 | 0.02238 | -0.6485 | -0.6659 | 2.1689 | 0.9622 | 0.9952 | 1.7373 | |
| HCC1954 | HER2amp | Basal A | Taxol | TUBB | TUBB | 9386.002 | uM | 0.00820 | 0.01263 | -0.7475 | -0.7279 | 2.0803 | 1.0631 | 0.9982 | 1.4405 | |
| HCC1954 | HER2amp | Basal A | Taxol | TUBB | TUBB | 7839.002 | uM | 0.00813 | 0.01010 | -0.5212 | -0.4771 | 3.0942 | 0.9216 | 0.9983 | 1.7009 | |
| HCC1954 | HER2amp | Basal A | TCS 2312 | CHK1 | CHK | 11055.152 | uM | 3.04350 | 3.11220 | -0.0401 | -0.0402 | 3.4621 | 0.1632 | 0.9931 | 1.6647 | |
| HCC1954 | HER2amp | Basal A | TCS PIM-1 1 | Pim kinase | PIM | 11055.135 | uM | 46.2940 | 24.99730 | 0.4765 | 0.4764 | 4.9553 | 0.0696 | 0.9858 | 1.7110 | |
| HCC1954 | HER2amp | Basal A | Temsirolimus | MTOR | MTOR | 11055.144 | uM | 0.43554 | 14.37860 | -0.8972 | -1.0000 | 0.3142 | 0.5308 | 0.7242 | 1.6716 | |
| HCC1954 | HER2amp | Basal A | Topotecan | TOP1 | TOP | 7837.007 | uM | 0.21411 | 0.63712 | -0.7934 | -0.7964 | 0.8737 | 0.7222 | 0.9943 | 1.6436 | |
| HCC1954 | HER2amp | Basal A | Topotecan | TOP1 | TOP | 9386.121 | uM | 0.42727 | 0.70133 | -0.7658 | -0.6961 | 1.7602 | 0.6382 | 0.9965 | 1.1728 | |
| HCC1954 | HER2amp | Basal A | Torkinib | 15389.211 | uM | 0.00178 | 0.04055 | -0.4956 | -0.6649 | 0.2706 | 0.8938 | 0.9832 | 1.6724 | |||
| HCC1954 | HER2amp | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 11055.15 | uM | 5.97960 | 13.33980 | -0.5795 | -1.0000 | 1.3692 | 0.1720 | 0.9895 | 1.6412 | |
| HCC1954 | HER2amp | Basal A | TPCA-1 | IKK | NFKB | 7454.093 | uM | inf | inf | 0.7670 | 0.7670 | 0.0000 | 0.2123 | -0.1144 | 1.3347 | |
| HCC1954 | HER2amp | Basal A | TPCA-1 | IKK | NFKB | 10469.1 | uM | 33.23410 | 15.92150 | 0.3325 | 0.1873 | 0.6379 | 0.1496 | 0.9509 | 1.5717 | |
| HCC1954 | HER2amp | Basal A | TPCA-1 | IKK | NFKB | 7455.093 | uM | 18.36330 | 4.43120 | 0.4095 | 0.3765 | 0.9838 | 0.1230 | 0.9827 | 1.7255 | |
| HCC1954 | HER2amp | Basal A | Trametinib | MEK | MAPK | 9386.012 | uM | 0.45911 | 36.31230 | -0.0208 | -1.0000 | 0.2514 | 0.3401 | 0.8219 | 1.4141 |