Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1937 | TNBC | Basal A | Fascaplysin | CDK4 | CDK | 7452.084 | uM | 0.36891 | 0.53806 | -0.9076 | -0.8914 | 2.7117 | 0.6139 | 0.9991 | 1.6800 | |
| HCC1937 | TNBC | Basal A | Fascaplysin | CDK4 | CDK | 7453.084 | uM | 0.39018 | 0.69380 | -0.9298 | -0.9314 | 1.8274 | 0.5916 | 0.9995 | 1.5592 | |
| HCC1937 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 11849.161 | uM | 119.06440 | 96.69970 | 0.6317 | 0.3199 | 4.9076 | -0.0195 | 0.8842 | 1.2764 | |
| HCC1937 | TNBC | Basal A | FTase Inhibitor I | Ftase | MAPK | 11849.154 | uM | inf | inf | 0.9386 | 0.9386 | 0.0000 | 0.0392 | 0.0000 | 1.1927 | |
| HCC1937 | TNBC | Basal A | Gefitinib | EGFR | ErbB | 7834.016 | uM | 12.13970 | 72.99190 | 0.1862 | -1.0000 | 0.6124 | 0.1344 | 0.9167 | 2.0442 | |
| HCC1937 | TNBC | Basal A | Gefitinib | EGFR | ErbB | 7832.016 | uM | 8.66080 | 24.40410 | -0.1907 | -1.0000 | 1.0605 | 0.1420 | 0.9661 | 1.2588 | |
| HCC1937 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 7832.04 | uM | 0.02733 | 0.03040 | -0.4324 | -0.3507 | 5.0000 | 0.8342 | 0.9950 | 1.2889 | |
| HCC1937 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 10262.012 | uM | 0.03179 | 0.04650 | -0.7724 | -0.7679 | 2.4460 | 1.0317 | 0.9981 | 0.5802 | |
| HCC1937 | TNBC | Basal A | Gemcitabine | DNA replication | DNA replication | 7832.011 | uM | 1.14790 | 0.46043 | 0.2149 | 0.1433 | 0.3695 | 0.3939 | 0.9567 | 1.4385 | |
| HCC1937 | TNBC | Basal A | Gemcitabine | DNA replication | DNA replication | 7834.075 | uM | 3.13870 | 0.40130 | 0.3039 | 0.3158 | 0.4855 | 0.3901 | 0.9676 | 2.0182 | |
| HCC1937 | TNBC | Basal A | Glycyl-H-1152 | ROCK2 | 11849.16 | uM | inf | 14.11340 | 0.5722 | 0.5720 | 5.0000 | 0.0444 | 0.8948 | 1.2119 | ||
| HCC1937 | TNBC | Basal A | GSK1070916 | AURK | AURK | 7833.001 | uM | 0.01219 | 1.75840 | -0.7330 | -1.0000 | 0.2210 | 0.6727 | 0.7373 | 1.0468 | |
| HCC1937 | TNBC | Basal A | GSK1070916 | AURK | AURK | 10262.001 | uM | 0.45278 | 8.84950 | -0.4796 | -1.0000 | 0.3696 | 0.3939 | 0.8872 | 0.6105 | |
| HCC1937 | TNBC | Basal A | GSK1070916 | AURK | AURK | 7834.001 | uM | 5.86390 | 17.22350 | -0.3887 | -1.0000 | 1.0196 | 0.2413 | 0.9142 | 2.0219 | |
| HCC1937 | TNBC | Basal A | GSK1838705A | IGF1R | RTK | 7452.098 | uM | inf | 2.82580 | 0.7741 | 0.8553 | 5.0000 | 0.0344 | 0.6486 | 1.6799 | |
| HCC1937 | TNBC | Basal A | GSK1838705A | IGF1R | RTK | 7453.098 | uM | 4.39920 | 4.650 | -0.5351 | -0.1597 | 4.9999 | 0.2277 | 0.8780 | 1.4660 | |
| HCC1937 | TNBC | Basal A | GSK1838705A | IGF1R | RTK | 7453.091 | uM | 14.24950 | 16.64250 | -0.5833 | -0.5834 | 4.9811 | 0.3080 | 0.9934 | 1.5914 | |
| HCC1937 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 7833.001 | uM | 0.00113 | 0.07446 | -0.7706 | -1.0000 | 0.2625 | 0.9401 | 0.7814 | 1.0468 | |
| HCC1937 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 7834.001 | uM | 0.06493 | 0.41521 | -0.2224 | -0.4745 | 0.3597 | 0.5416 | 0.9684 | 2.0219 | |
| HCC1937 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 10262.001 | uM | 0.03047 | 0.25135 | -0.8658 | -0.9195 | 0.4945 | 0.7234 | 0.9769 | 0.6105 | |
| HCC1937 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 7833.001 | uM | 0.00335 | 0.00581 | -0.2423 | -0.1358 | 0.4379 | 0.7376 | 0.8118 | 1.0468 | |
| HCC1937 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 10262.001 | uM | 0.02489 | 0.02384 | -0.1295 | 0.0319 | 1.5210 | 0.5180 | 0.9664 | 0.6105 | |
| HCC1937 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 7834.001 | uM | 0.09009 | 0.05744 | 0.2323 | 0.3025 | 2.0633 | 0.3394 | 0.9868 | 2.0219 | |
| HCC1937 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 7453.088 | uM | inf | inf | 0.9998 | 0.9998 | 0.0000 | -0.0300 | -1.8689 | 1.5634 | |
| HCC1937 | TNBC | Basal A | Ibandronate | FDPS | 11849.143 | uM | 29.64570 | 34.76780 | -0.0797 | -0.0956 | 1.0980 | 0.3080 | 0.9957 | 1.3433 |