Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1569 | HER2amp | Basal A | Sigma A6730 | AKT | AKT | 10872.153 | uM | 9.73860 | 17.79130 | -0.8670 | -1.0000 | 1.8231 | 0.2406 | 0.9913 | 1.5576 | |
| HCC1569 | HER2amp | Basal A | Sigma A6730 | AKT | AKT | 12523.165 | uM | 8.57050 | 18.45990 | -0.5139 | -0.8139 | 1.2592 | 0.2049 | 0.9973 | 1.0249 | |
| HCC1569 | HER2amp | Basal A | Sirolimus | MTOR | MTOR | 7824.068 | uM | 1.5290 | 999.99450 | 0.1952 | -0.5186 | 0.1098 | 0.4482 | 0.6902 | 1.5619 | |
| HCC1569 | HER2amp | Basal A | Sirolimus | MTOR | MTOR | 7827.068 | uM | 0.18897 | 2.8360 | -0.0235 | -0.3457 | 0.1940 | 0.5357 | 0.8566 | 1.1786 | |
| HCC1569 | HER2amp | Basal A | Sirolimus | MTOR | MTOR | 7447.068 | uM | 0.01777 | 0.00189 | 0.2985 | 0.3535 | 0.5478 | 0.5385 | 0.9617 | 1.5836 | |
| HCC1569 | HER2amp | Basal A | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7448.084 | uM | 377.7270 | 582.81760 | -0.5975 | -1.0000 | 2.5331 | 0.1873 | 0.8866 | 2.8225 | |
| HCC1569 | HER2amp | Basal A | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7449.084 | uM | 96.43570 | 56.02520 | 0.3520 | 0.4669 | 5.0000 | 0.1506 | 0.8883 | 2.1410 | |
| HCC1569 | HER2amp | Basal A | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7447.084 | uM | 49.56820 | 67.98270 | -0.9217 | -0.9241 | 3.3134 | 0.4033 | 0.9985 | 1.5152 | |
| HCC1569 | HER2amp | Basal A | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7449.067 | uM | inf | inf | -0.7828 | -0.7828 | 0.0000 | 0.2385 | 0.4093 | 1.9771 | |
| HCC1569 | HER2amp | Basal A | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7447.067 | uM | 7.05180 | 10.27510 | -0.9623 | -0.9663 | 2.8581 | 0.4142 | 0.9990 | 1.5637 | |
| HCC1569 | HER2amp | Basal A | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7448.067 | uM | 9.64030 | 13.36540 | -0.6825 | -0.6845 | 2.6397 | 0.3276 | 0.9997 | 2.8462 | |
| HCC1569 | HER2amp | Basal A | Taxol | TUBB | TUBB | 9347.002 | uM | 0.01361 | 0.00945 | 0.3664 | 0.4193 | 4.9989 | 0.3606 | 0.9845 | 1.4904 | |
| HCC1569 | HER2amp | Basal A | Taxol | TUBB | TUBB | 13038.002 | uM | 0.01142 | 0.01074 | 0.0639 | 0.1336 | 5.0000 | 0.5396 | 0.9898 | 1.2045 | |
| HCC1569 | HER2amp | Basal A | TCS 2312 | CHK1 | CHK | 10872.152 | uM | 0.45631 | 0.58592 | -0.4297 | -0.3973 | 2.3390 | 0.4808 | 0.9894 | 1.5916 | |
| HCC1569 | HER2amp | Basal A | TCS 2312 | CHK1 | CHK | 12523.152 | uM | 0.51831 | 0.61186 | -0.7533 | -0.6456 | 4.9967 | 0.4818 | 0.9912 | 0.8423 | |
| HCC1569 | HER2amp | Basal A | TCS PIM-1 1 | Pim kinase | PIM | 12523.135 | uM | inf | inf | 0.8989 | 0.8989 | 0.0000 | -0.0174 | 0.4377 | 0.8958 | |
| HCC1569 | HER2amp | Basal A | TCS PIM-1 1 | Pim kinase | PIM | 10872.148 | uM | inf | inf | 0.7165 | 0.7165 | 0.0000 | 0.0270 | 0.4986 | 1.5151 | |
| HCC1569 | HER2amp | Basal A | Temsirolimus | MTOR | MTOR | 10872.144 | uM | 1.01770 | 19.31340 | -0.8843 | -1.0000 | 0.3733 | 0.4792 | 0.7299 | 1.5447 | |
| HCC1569 | HER2amp | Basal A | Temsirolimus | MTOR | MTOR | 12523.168 | uM | 1.65560 | 16.16170 | -0.9526 | -1.0000 | 0.4822 | 0.4550 | 0.8142 | 0.9035 | |
| HCC1569 | HER2amp | Basal A | Topotecan | TOP1 | TOP | 7825.007 | uM | 7.49910 | 55.04090 | -0.2342 | -1.0000 | 0.5512 | 0.2742 | 0.9642 | 1.5199 | |
| HCC1569 | HER2amp | Basal A | Topotecan | TOP1 | TOP | 9347.121 | uM | 0.38685 | 0.43297 | -0.0698 | -0.0755 | 1.2491 | 0.4610 | 0.9938 | 1.4523 | |
| HCC1569 | HER2amp | Basal A | Torkinib | 15388.211 | uM | 0.00154 | 0.18585 | -0.5621 | -1.0000 | 0.2292 | 0.9195 | 0.9903 | 1.5247 | |||
| HCC1569 | HER2amp | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 12523.169 | uM | 1.51170 | 10.62030 | -0.8801 | -1.0000 | 0.5635 | 0.4311 | 0.9141 | 1.0498 | |
| HCC1569 | HER2amp | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 10872.15 | uM | 2.77970 | 38.01430 | -0.0563 | -1.0000 | 0.4200 | 0.2568 | 0.9220 | 1.6255 | |
| HCC1569 | HER2amp | Basal A | TPCA-1 | IKK | NFKB | 10442.093 | uM | 3.53090 | 3.58680 | 0.0292 | -0.0091 | 1.1506 | 0.2378 | 0.9922 | 1.6861 |