Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1569 | HER2amp | Basal A | Trametinib | MEK | MAPK | 9347.012 | uM | 83.82420 | 43.14150 | 0.8337 | 0.2840 | 1.2636 | 0.0041 | 0.5961 | 1.4653 | |
| HCC1569 | HER2amp | Basal A | Trametinib | MEK | MAPK | 7825.05 | uM | inf | 0.19981 | 0.8803 | 0.9102 | 1.5216 | 0.0228 | 0.7426 | 1.8354 | |
| HCC1569 | HER2amp | Basal A | Trastuzumab | HER2 | ErbB | 9347.026 | uM | inf | inf | 0.7097 | 0.7097 | 0.0000 | 0.0656 | 0.4960 | 1.2965 | |
| HCC1569 | HER2amp | Basal A | Trastuzumab | HER2 | ErbB | 7447.102 | uM | inf | 0.00181 | 0.7277 | 0.8106 | 1.1886 | 0.1183 | 0.8186 | 1.6467 | |
| HCC1569 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 7449.065 | uM | 10.31640 | 13.80030 | -0.5599 | -0.4969 | 2.3715 | 0.6932 | 0.9899 | 2.0765 | |
| HCC1569 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 7448.065 | uM | 10.78020 | 13.93290 | -0.3745 | -0.3037 | 1.8500 | 0.6028 | 0.9943 | 2.6104 | |
| HCC1569 | HER2amp | Basal A | Triciribine | AKT | AKT | 7447.074 | uM | 4.59260 | 1000.00000 | 0.3985 | -0.6705 | 0.1580 | 0.3206 | 0.8409 | 1.5411 | |
| HCC1569 | HER2amp | Basal A | Triciribine | AKT | AKT | 7448.074 | uM | inf | 4.66670 | 0.6704 | 0.5030 | 0.3643 | 0.1183 | 0.9882 | 2.8830 | |
| HCC1569 | HER2amp | Basal A | Triciribine | AKT | AKT | 7449.074 | uM | inf | 3.22310 | 0.6008 | 0.4529 | 0.4257 | 0.1312 | 0.9912 | 2.0321 | |
| HCC1569 | HER2amp | Basal A | Valproic acid | HDAC | HDAC | 12523.143 | uM | 606.29240 | 1000.00000 | -0.7515 | -0.3965 | 1.1669 | 0.2570 | 0.8542 | 0.9700 | |
| HCC1569 | HER2amp | Basal A | Valproic acid | HDAC | HDAC | 10872.143 | uM | 698.99170 | 1000.00000 | -0.6096 | -0.2937 | 1.2905 | 0.2442 | 0.8730 | 1.6364 | |
| HCC1569 | HER2amp | Basal A | Vinorelbine | TUBB | TUBB | 7825.018 | uM | 0.08023 | 2.50330 | -0.7704 | -1.0000 | 0.3193 | 0.5970 | 0.8784 | 1.9741 | |
| HCC1569 | HER2amp | Basal A | Vinorelbine | TUBB | TUBB | 7824.018 | uM | 0.40848 | 2.66520 | -0.9069 | -1.0000 | 0.5858 | 0.4697 | 0.9558 | 1.3115 | |
| HCC1569 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 7449.065 | uM | 114.62720 | 222.44580 | -0.5646 | -0.5671 | 1.1434 | 0.5339 | 0.9970 | 2.0765 | |
| HCC1569 | HER2amp | Basal A | Vorinostat | HDAC | HDAC | 7448.065 | uM | 151.81330 | 231.43780 | -0.3359 | -0.3483 | 1.2536 | 0.4676 | 0.9988 | 2.6104 | |
| HCC1569 | HER2amp | Basal A | XRP44X | ELK3 | MAPK | 12523.157 | uM | inf | 70.6480 | 0.7471 | 0.5490 | 0.2109 | 0.1165 | 0.7864 | 0.9728 | |
| HCC1569 | HER2amp | Basal A | XRP44X | ELK3 | MAPK | 10872.151 | uM | 5.73120 | 2.10430 | 0.3264 | 0.3247 | 1.0459 | 0.2115 | 0.9837 | 1.4028 | |
| HCC1569 | HER2amp | Basal A | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14245.189 | uM | 0.48346 | 0.66209 | -0.4065 | -0.4086 | 1.8997 | 0.5800 | 0.9643 | 1.4693 | |
| HCC1569 | HER2amp | Basal A | ZM-447439 | AURK | AURK | 10872.15 | uM | inf | 0.35621 | 0.5700 | 0.5657 | 1.8837 | 0.1901 | 0.8828 | 1.6255 | |
| HCC1569 | HER2amp | Basal A | ZM-447439 | AURK | AURK | 12523.169 | uM | 2.07870 | 2.01410 | 0.0185 | 0.0731 | 5.0000 | 0.2305 | 0.9846 | 1.0498 | |
| HCC1806 | TNBC | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 7830.016 | uM | inf | inf | 0.2581 | 0.2581 | 0.0000 | 0.1910 | 0.3538 | 2.0313 | ||
| HCC1806 | TNBC | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 7829.016 | uM | 13.43190 | 18.22980 | -0.8442 | -0.8456 | 3.2414 | 0.3225 | 0.9995 | 1.9532 | ||
| HCC1806 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 9376.037 | uM | 0.06469 | 0.08209 | -0.6328 | -0.4476 | 2.6828 | 0.7821 | 0.9880 | 1.3761 | |
| HCC1806 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 7829.04 | uM | 0.11945 | 0.15120 | -0.4061 | -0.3563 | 2.2825 | 0.6836 | 0.9973 | 1.9437 | |
| HCC1806 | TNBC | Basal A | 2-deoxyglucose | 12702.177 | uM | 556.93120 | 1000.00000 | -0.1052 | -0.4162 | 1.0348 | 0.1905 | 0.9832 | 1.5730 |