Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1428 | HR+ | Luminal | QNZ | NFkB | NFKB | 7442.096 | uM | 0.05133 | 0.03292 | 0.2055 | 0.2115 | 1.2374 | 0.4267 | 0.9952 | 0.7665 | |
| HCC1428 | HR+ | Luminal | Ribavirin | 15350.211 | uM | inf | inf | 0.8894 | 0.8894 | 0.0000 | 0.0337 | 0.3498 | 1.0306 | |||
| HCC1428 | HR+ | Luminal | SB-3CT | MMP2/9 | MMP | 11936.144 | uM | inf | inf | 0.7149 | 0.7149 | 0.0000 | 0.1094 | 0.4821 | 0.8864 | |
| HCC1428 | HR+ | Luminal | SB-3CT | MMP2/9 | MMP | 10693.144 | uM | 32.03330 | 61.42970 | -0.3902 | -1.0000 | 1.6873 | 0.1276 | 0.9857 | 0.8585 | |
| HCC1428 | HR+ | Luminal | Selumetinib | MEK | MAPK | 11936.155 | uM | inf | inf | 1.0472 | 1.0472 | 0.0000 | -0.0048 | -0.0036 | 0.7332 | |
| HCC1428 | HR+ | Luminal | Selumetinib | MEK | MAPK | 10693.146 | uM | inf | inf | 0.8351 | 0.8351 | 0.0000 | 0.0516 | 0.1098 | 0.8826 | |
| HCC1428 | HR+ | Luminal | Sigma A6730 | AKT | AKT | 11936.158 | uM | 3.38090 | 9.20560 | -0.9891 | -1.0000 | 1.0968 | 0.4375 | 0.9221 | 0.7417 | |
| HCC1428 | HR+ | Luminal | Sigma A6730 | AKT | AKT | 10693.153 | uM | 3.63940 | 9.60190 | -0.9834 | -1.0000 | 1.1324 | 0.3920 | 0.9640 | 0.8137 | |
| HCC1428 | HR+ | Luminal | Sirolimus | MTOR | MTOR | 7441.068 | uM | 0.05063 | 0.43912 | -0.0852 | -0.3113 | 0.2241 | 0.6254 | 0.8277 | 0.7801 | |
| HCC1428 | HR+ | Luminal | Sirolimus | MTOR | MTOR | 7444.069 | uM | 0.04448 | 1.09320 | -0.1444 | -0.5261 | 0.2245 | 0.5395 | 0.9188 | 0.9426 | |
| HCC1428 | HR+ | Luminal | Sirolimus | MTOR | MTOR | 7443.068 | uM | 0.04387 | 0.01554 | 0.1983 | 0.3198 | 0.9833 | 0.4791 | 0.9312 | 1.1167 | |
| HCC1428 | HR+ | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7444.084 | uM | inf | inf | 0.3255 | 0.3255 | 0.0000 | 0.1199 | 0.2928 | 0.8647 | |
| HCC1428 | HR+ | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7443.084 | uM | 28.18330 | 32.83130 | -0.7404 | -0.5726 | 5.0000 | 0.4589 | 0.9738 | 0.9878 | |
| HCC1428 | HR+ | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7442.085 | uM | 92.66040 | 146.47610 | -0.7588 | -1.0000 | 2.3991 | 0.1857 | 0.9848 | 0.8237 | |
| HCC1428 | HR+ | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7441.084 | uM | 40.75420 | 62.57180 | -0.9676 | -0.9832 | 2.5361 | 0.4415 | 0.9942 | 0.8431 | |
| HCC1428 | HR+ | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7441.067 | uM | 4.44990 | 8.2370 | -0.9974 | -1.0000 | 1.7842 | 0.5285 | 0.9786 | 0.8233 | |
| HCC1428 | HR+ | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7443.067 | uM | 5.72730 | 8.93080 | -0.9909 | -1.0000 | 2.4729 | 0.5168 | 0.9844 | 1.0344 | |
| HCC1428 | HR+ | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7442.067 | uM | 5.55930 | 8.32030 | -0.9894 | -1.0000 | 2.7245 | 0.5335 | 0.9853 | 0.9126 | |
| HCC1428 | HR+ | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7444.067 | uM | 5.56940 | 8.47330 | -0.9996 | -1.0000 | 2.6181 | 0.4675 | 0.9936 | 0.7382 | |
| HCC1428 | HR+ | Luminal | TAPI-0 | TACE/Collagenase | 7442.096 | uM | 37.80890 | 407.90930 | 0.5074 | -1.0000 | 0.4619 | 0.1032 | 0.9606 | 0.7665 | ||
| HCC1428 | HR+ | Luminal | Taxol | TUBB | TUBB | 10031.002 | uM | inf | 0.01672 | 0.4898 | 0.5157 | 1.5331 | 0.2758 | 0.9802 | 0.6483 | |
| HCC1428 | HR+ | Luminal | Taxol | TUBB | TUBB | 9294.002 | uM | 0.01980 | 0.01237 | 0.1991 | 0.2343 | 1.3450 | 0.4594 | 0.9887 | 0.7467 | |
| HCC1428 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 11936.159 | uM | 0.66227 | 1.12950 | -0.9852 | -0.9812 | 2.0341 | 0.5428 | 0.9903 | 0.7472 | |
| HCC1428 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 10693.152 | uM | 0.71115 | 1.24860 | -0.8598 | -0.8990 | 1.8279 | 0.5340 | 0.9917 | 0.8734 | |
| HCC1428 | HR+ | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 11936.135 | uM | 74.19980 | 410.43960 | 0.3382 | -1.0000 | 0.6423 | 0.1138 | 0.9279 | 0.8584 |