Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1428 | HR+ | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 10693.148 | uM | 70.82850 | 38.34270 | 0.5133 | 0.4143 | 2.8745 | 0.0580 | 0.9373 | 0.8983 | |
| HCC1428 | HR+ | Luminal | Temsirolimus | MTOR | MTOR | 10693.144 | uM | 0.45772 | 9.90080 | -0.9911 | -1.0000 | 0.3574 | 0.5735 | 0.7381 | 0.8585 | |
| HCC1428 | HR+ | Luminal | Temsirolimus | MTOR | MTOR | 11936.144 | uM | 1.57460 | 10.87720 | -0.9761 | -1.0000 | 0.5684 | 0.5044 | 0.8946 | 0.8864 | |
| HCC1428 | HR+ | Luminal | Topotecan | TOP1 | TOP | 9299.121 | uM | 0.39804 | 0.98295 | -0.9813 | -1.0000 | 1.2153 | 0.7190 | 0.9971 | 0.4126 | |
| HCC1428 | HR+ | Luminal | Topotecan | TOP1 | TOP | 9294.121 | uM | 0.48514 | 0.9180 | -0.9294 | -0.9156 | 1.6318 | 0.6878 | 0.9984 | 0.7502 | |
| HCC1428 | HR+ | Luminal | Torkinib | 15350.211 | uM | 0.00051 | 0.02111 | -0.6104 | -0.8283 | 0.2630 | 1.0478 | 0.9487 | 1.0306 | |||
| HCC1428 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 11936.16 | uM | 6.02670 | 464.81460 | 0.1900 | -1.0000 | 0.2528 | 0.2571 | 0.7279 | 0.8962 | |
| HCC1428 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 10693.15 | uM | 5.98660 | 21.51970 | -0.1914 | -1.0000 | 0.8587 | 0.1649 | 0.9856 | 0.7763 | |
| HCC1428 | HR+ | Luminal | TPCA-1 | IKK | NFKB | 7442.1 | uM | 1.72470 | 1.27450 | 0.2671 | 0.3898 | 4.9999 | 0.2391 | 0.8671 | 0.8780 | |
| HCC1428 | HR+ | Luminal | TPCA-1 | IKK | NFKB | 10441.093 | uM | 5.04070 | 3.58220 | 0.1672 | 0.1061 | 0.6985 | 0.2229 | 0.9443 | 1.1458 | |
| HCC1428 | HR+ | Luminal | Trametinib | MEK | MAPK | 10031.012 | uM | inf | inf | 0.5863 | 0.5863 | 0.0000 | 0.0897 | 0.2387 | 0.7110 | |
| HCC1428 | HR+ | Luminal | Trametinib | MEK | MAPK | 9294.012 | uM | inf | 1.84370 | 0.7010 | 0.6918 | 1.6631 | 0.0716 | 0.8916 | 0.9035 | |
| HCC1428 | HR+ | Luminal | Trastuzumab | HER2 | ErbB | 7441.102 | uM | inf | inf | 0.9313 | 0.9313 | 0.0000 | -0.0087 | 0.3093 | 0.9144 | |
| HCC1428 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 7443.065 | uM | 1.70780 | 2.75150 | -0.9769 | -0.9745 | 2.2675 | 1.1356 | 0.9991 | 0.8818 | |
| HCC1428 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 7444.065 | uM | 1.45170 | 2.67320 | -0.9873 | -0.9919 | 1.7904 | 1.1581 | 0.9992 | 0.7419 | |
| HCC1428 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 7442.065 | uM | 2.44840 | 3.90930 | -0.9897 | -0.9908 | 2.3347 | 1.0970 | 0.9995 | 0.7805 | |
| HCC1428 | HR+ | Luminal | Triciribine | AKT | AKT | 7441.074 | uM | 0.06776 | 0.79166 | -0.7654 | -1.0000 | 0.4469 | 0.6528 | 0.9650 | 0.8339 | |
| HCC1428 | HR+ | Luminal | Triciribine | AKT | AKT | 7444.074 | uM | 0.07381 | 0.66308 | -0.7515 | -1.0000 | 0.5004 | 0.6294 | 0.9813 | 0.7602 | |
| HCC1428 | HR+ | Luminal | Triciribine | AKT | AKT | 7443.074 | uM | 0.07430 | 0.83250 | -0.7353 | -1.0000 | 0.4547 | 0.6180 | 0.9904 | 0.8753 | |
| HCC1428 | HR+ | Luminal | Triciribine | AKT | AKT | 7442.074 | uM | 0.11298 | 0.66650 | -0.9039 | -1.0000 | 0.6190 | 0.6324 | 0.9958 | 0.8143 | |
| HCC1428 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 11936.143 | uM | 672.03980 | 1000.00000 | -0.9873 | -0.9368 | 2.6560 | 0.4726 | 0.9723 | 0.7979 | |
| HCC1428 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 10693.143 | uM | 632.3180 | 1000.00000 | -0.9901 | -0.9992 | 2.3956 | 0.4338 | 0.9970 | 0.7509 | |
| HCC1428 | HR+ | Luminal | Vinorelbine | TUBB | TUBB | 9294.125 | uM | 0.47685 | 3.59210 | -0.9968 | -1.0000 | 0.5441 | 0.8355 | 0.8522 | 0.6999 | |
| HCC1428 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 7443.065 | uM | 35.62970 | 56.68970 | -0.9861 | -0.9845 | 2.3432 | 0.8811 | 0.9992 | 0.8818 | |
| HCC1428 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 7442.065 | uM | 37.32660 | 57.23520 | -0.9937 | -0.9931 | 2.5592 | 0.8858 | 0.9992 | 0.7805 |