Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1419 | HER2amp | Luminal | Olomoucine II | CDK1 | CDK | 12001.147 | uM | 2.99980 | 11.99860 | -0.7048 | -1.0000 | 0.7925 | 0.4618 | 0.9453 | 0.5989 | |
| HCC1419 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 7437.086 | uM | 0.0020 | 0.00570 | -0.9790 | -0.8720 | 0.9632 | 1.2599 | 0.9859 | 0.4150 | |
| HCC1419 | HER2amp | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 7820.011 | uM | 37.0910 | 59.21560 | -0.9325 | -0.9496 | 2.2753 | 0.4438 | 0.9589 | 0.6709 | |
| HCC1419 | HER2amp | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 9278.011 | uM | 8.46420 | 30.49560 | -0.9763 | -1.0000 | 0.8571 | 0.5124 | 0.9604 | 0.5434 | |
| HCC1419 | HER2amp | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 10019.12 | uM | 9.94530 | 28.0190 | -0.9970 | -1.0000 | 1.0607 | 0.5208 | 0.9649 | 0.4898 | |
| HCC1419 | HER2amp | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 7819.075 | uM | 21.6960 | 48.16140 | -0.9798 | -1.0000 | 1.3777 | 0.4385 | 0.9760 | 0.5386 | |
| HCC1419 | HER2amp | Luminal | Oxamflatin | HDAC | HDAC | 12001.147 | uM | 1.24950 | 3.34120 | -0.9989 | -1.0000 | 1.1169 | 0.5960 | 0.8993 | 0.5989 | |
| HCC1419 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 12001.159 | uM | inf | inf | 0.4036 | 0.4036 | 0.0000 | 0.2866 | 0.4547 | 0.7107 | |
| HCC1419 | HER2amp | Luminal | PD173074 | FGFR1/3 | RTK | 7437.093 | uM | 10.27450 | 24.86360 | -0.1998 | -1.0000 | 1.2431 | 0.1989 | 0.8755 | 0.4731 | |
| HCC1419 | HER2amp | Luminal | PD184352 | MEK | MAPK | 12001.155 | uM | inf | inf | 0.6410 | 0.6410 | 0.0000 | 0.1501 | 0.5358 | 0.5973 | |
| HCC1419 | HER2amp | Luminal | PD184352 | MEK | MAPK | 12001.155 | uM | inf | inf | 0.6410 | 0.6410 | 0.0000 | 0.1501 | 0.5358 | 0.5973 | |
| HCC1419 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7437.095 | uM | inf | inf | 0.9403 | 0.9403 | 0.0000 | 0.1007 | -0.0689 | 0.5584 | |
| HCC1419 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7440.095 | uM | inf | inf | 0.6165 | 0.6165 | 0.0000 | 0.2930 | 0.2845 | 0.5907 | |
| HCC1419 | HER2amp | Luminal | PS-1145 | IKK | NFKB | 7440.065 | uM | inf | inf | 0.9343 | 0.9343 | 0.0000 | 0.1126 | 0.0000 | 0.5818 | |
| HCC1419 | HER2amp | Luminal | PS-1145 | IKK | NFKB | 7437.065 | uM | inf | inf | 1.0125 | 1.0125 | 0.0000 | 0.0500 | 0.1389 | 0.5183 | |
| HCC1419 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 7437.067 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0473 | -48.7760 | 0.4038 | |
| HCC1419 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 7440.067 | uM | inf | 22.81910 | 0.5139 | 0.5132 | 5.0000 | 0.0456 | 0.9597 | 0.3519 | |
| HCC1419 | HER2amp | Luminal | SB-3CT | MMP2/9 | MMP | 12001.168 | uM | inf | inf | 0.7686 | 0.7686 | 0.0000 | 0.0542 | 0.4350 | 0.4934 | |
| HCC1419 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 12001.155 | uM | 11.51560 | 998.95870 | 0.4094 | -0.5983 | 0.1763 | 0.2840 | 0.9054 | 0.5973 | |
| HCC1419 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 12001.165 | uM | 0.81605 | 3.11870 | -0.9607 | -1.0000 | 0.8194 | 0.5612 | 0.9606 | 0.5382 | |
| HCC1419 | HER2amp | Luminal | Sirolimus | MTOR | MTOR | 7819.068 | uM | 0.00097 | 0.00953 | -0.9999 | -0.6956 | 0.3814 | 1.1819 | 0.8465 | 0.4460 | |
| HCC1419 | HER2amp | Luminal | Sirolimus | MTOR | MTOR | 7818.068 | uM | 0.00361 | 0.00461 | -0.2968 | -0.0865 | 0.6554 | 0.8440 | 0.9116 | 0.7038 | |
| HCC1419 | HER2amp | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7437.084 | uM | inf | inf | 0.9273 | 0.9273 | 0.0000 | 0.1333 | 0.0343 | 0.4343 | |
| HCC1419 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7437.067 | uM | inf | inf | -0.9973 | -0.9973 | 0.0000 | 0.2089 | 0.4251 | 0.4038 | |
| HCC1419 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7440.067 | uM | 12.61540 | 15.71650 | -1.0000 | -1.0000 | 4.9984 | 0.3537 | 0.9966 | 0.3519 |