Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 10019.001 | uM | 1.07080 | 10.8130 | -0.4023 | -1.0000 | 0.4751 | 0.3243 | 0.8739 | 0.3968 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 9278.001 | uM | 0.11964 | 0.15670 | -0.3034 | -0.1139 | 0.7607 | 0.4390 | 0.9111 | 0.4429 | |
| HCC1419 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 7437.088 | uM | 36.37440 | 47.15110 | 0.6185 | -0.9047 | 3.9808 | 0.0343 | 0.7610 | 0.4809 | |
| HCC1419 | HER2amp | Luminal | Ibandronate | FDPS | 12001.143 | uM | 6.0330 | 16.33460 | -0.4306 | -0.5212 | 0.7170 | 0.5387 | 0.9911 | 0.6160 | ||
| HCC1419 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 12001.157 | uM | inf | inf | 0.7140 | 0.7140 | 0.0000 | 0.2086 | 0.0169 | 0.5904 | |
| HCC1419 | HER2amp | Luminal | IKK16 | IKK | NFKB | 7437.093 | uM | 3.7820 | 5.03950 | -0.9998 | -0.9994 | 3.8258 | 0.3681 | 0.9975 | 0.4731 | |
| HCC1419 | HER2amp | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 7440.091 | uM | 13.33510 | 25.14190 | -1.0000 | -1.0000 | 1.7325 | 0.5992 | 0.9458 | 0.4250 | |
| HCC1419 | HER2amp | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 7437.091 | uM | 19.37990 | 28.07980 | -1.0000 | -1.0000 | 2.9627 | 0.4660 | 0.9945 | 0.3419 | |
| HCC1419 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 7440.067 | uM | 0.64274 | 4.48840 | -1.0000 | -1.0000 | 0.5653 | 0.3962 | 0.8048 | 0.3519 | |
| HCC1419 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 7437.067 | uM | 7.18670 | 9.59040 | -1.0000 | -1.0000 | 3.8076 | 0.2622 | 0.9186 | 0.4038 | |
| HCC1419 | HER2amp | Luminal | Ixabepilone | TUBB | TUBB | 7440.095 | uM | 0.08315 | 3.38350 | -0.9659 | -1.0000 | 0.2964 | 0.5492 | 0.6395 | 0.5907 | |
| HCC1419 | HER2amp | Luminal | Ixabepilone | TUBB | TUBB | 7437.095 | uM | 9.1730 | 11.91780 | -0.9996 | -1.0000 | 4.1969 | 0.3555 | 0.7786 | 0.5584 | |
| HCC1419 | HER2amp | Luminal | JNK-IN-5A | JNK | JNK | 12001.168 | uM | inf | 3.28940 | 0.3928 | 0.5167 | 4.9827 | 0.1823 | 0.7370 | 0.4934 | |
| HCC1419 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 12001.166 | uM | 1.69350 | 611.76270 | -0.0141 | -1.0000 | 0.1865 | 0.3320 | 0.5848 | 0.5565 | |
| HCC1419 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 7440.098 | uM | 0.24109 | 0.36741 | -0.4836 | -0.4736 | 1.5817 | 0.4699 | 0.9902 | 0.3606 | |
| HCC1419 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 12001.167 | uM | 0.03165 | 0.10778 | -0.9979 | -1.0000 | 0.8966 | 0.9663 | 0.9631 | 0.5287 | |
| HCC1419 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 12001.167 | uM | 0.53468 | 2.37870 | -0.9902 | -1.0000 | 0.7360 | 0.5855 | 0.8060 | 0.5287 | |
| HCC1419 | HER2amp | Luminal | Mebendazole | 12612.174 | uM | 12.26460 | 999.96270 | 0.2878 | -0.8873 | 0.2319 | 0.2576 | 0.9188 | 0.5962 | |||
| HCC1419 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 7437.084 | uM | inf | 0.41644 | 0.5569 | 0.4892 | 0.3083 | 0.2648 | 0.7939 | 0.4343 | |
| HCC1419 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 12001.135 | uM | 0.10592 | 0.31386 | -0.7806 | -0.8514 | 0.9153 | 0.8275 | 0.9666 | 0.4442 | |
| HCC1419 | HER2amp | Luminal | Nelfinavir | 12612.174 | uM | 1.79740 | 3.44750 | -0.9953 | -1.0000 | 1.6868 | 0.4407 | 0.9719 | 0.5962 | |||
| HCC1419 | HER2amp | Luminal | NSC 663284 | CDC25 | CDC | 12001.159 | uM | 1.55690 | 3.25510 | -0.9969 | -1.0000 | 1.4896 | 0.6941 | 0.9585 | 0.7107 | |
| HCC1419 | HER2amp | Luminal | NU6102 | CDK1/2 | CDK | 12001.147 | uM | inf | inf | 0.0047 | 0.0047 | 0.0000 | 0.2969 | 0.4684 | 0.5989 | |
| HCC1419 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 7440.066 | uM | inf | 16.58670 | 0.5399 | 0.5395 | 4.9875 | 0.0695 | 0.7841 | 0.4073 | |
| HCC1419 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 7437.066 | uM | 15.21620 | 14.75440 | 0.0714 | 0.0709 | 4.9607 | 0.1042 | 0.9605 | 0.3525 |