Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1395 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 9258.024 | uM | 5.95730 | 7.40140 | -0.9790 | -0.9801 | 4.9999 | 0.2284 | 0.9586 | 0.5251 | |
| HCC1395 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 7816.016 | uM | 12.91910 | 24.28270 | -0.2709 | -1.0000 | 1.7409 | 0.1554 | 0.9617 | 1.1183 | |
| HCC1395 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 9254.049 | uM | 6.73770 | 7.3520 | -0.2727 | -0.2734 | 4.9990 | 0.1444 | 0.9644 | 0.8730 | |
| HCC1395 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 7815.016 | uM | 27.86290 | 33.04340 | 0.1471 | -0.6729 | 4.9999 | 0.0165 | 0.9782 | 0.4370 | |
| HCC1395 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 7813.016 | uM | 6.6530 | 8.02730 | -0.7767 | -0.7782 | 4.9983 | 0.1663 | 0.9794 | 0.8531 | |
| HCC1395 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 7814.016 | uM | 8.07790 | 51.84210 | 0.1222 | -1.0000 | 0.5910 | 0.1669 | 0.9925 | 0.8623 | |
| HCC1395 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 9254.049 | uM | 0.74413 | 2.46190 | -0.0421 | -0.2443 | 0.3325 | 0.4007 | 0.8238 | 0.8730 | |
| HCC1395 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 7813.012 | uM | 0.01813 | 0.02165 | -0.0705 | -0.0323 | 0.3528 | 0.6395 | 0.8356 | 1.0493 | |
| HCC1395 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 9258.024 | uM | 0.02376 | 0.02636 | -0.5399 | -0.3387 | 4.9898 | 0.8590 | 0.9527 | 0.5251 | |
| HCC1395 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 7814.04 | uM | 0.05508 | 0.06471 | -0.1717 | -0.1078 | 1.2119 | 0.6135 | 0.9892 | 0.8711 | |
| HCC1395 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 7813.011 | uM | inf | 2.35980 | 0.6153 | 0.5805 | 4.9965 | 0.1441 | 0.7307 | 0.8718 | |
| HCC1395 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 9254.12 | uM | 7.13690 | 0.45857 | 0.3715 | 0.4768 | 1.1190 | 0.2056 | 0.8450 | 1.1139 | |
| HCC1395 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 9258.03 | uM | 0.05903 | 0.23991 | -0.6420 | -0.5382 | 0.5211 | 0.7273 | 0.9026 | 0.4015 | |
| HCC1395 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 9258.011 | uM | 0.61775 | 0.55858 | -0.0576 | 0.0419 | 0.8693 | 0.4128 | 0.9716 | 0.6984 | |
| HCC1395 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 7814.011 | uM | 0.12816 | 0.10485 | 0.0751 | 0.0440 | 0.4591 | 0.5277 | 0.9834 | 0.9472 | |
| HCC1395 | TNBC | Basal B | Glycyl-H-1152 | ROCK2 | 12084.16 | uM | 12.49510 | 36.59980 | -0.0127 | -0.6415 | 0.7681 | 0.1579 | 0.9673 | 1.1178 | ||
| HCC1395 | TNBC | Basal B | Glycyl-H-1152 | ROCK2 | 12000.169 | uM | 5.15510 | 75.12560 | -0.0066 | -1.0000 | 0.4101 | 0.2688 | 0.9786 | 0.8565 | ||
| HCC1395 | TNBC | Basal B | GM6001 | MMP | MMP | 7436.096 | uM | inf | inf | 0.8287 | 0.8287 | 0.0000 | 0.0732 | -0.0129 | 1.3979 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 9258.001 | uM | 0.09421 | 1.1910 | -0.9841 | -1.0000 | 0.4330 | 0.6113 | 0.8765 | 0.7137 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 9254.001 | uM | 5.38610 | 6.70950 | -1.0000 | -0.9998 | 5.0000 | 0.3079 | 0.9082 | 0.3986 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 7816.001 | uM | 0.59860 | 2.77790 | -0.9806 | -1.0000 | 0.7158 | 0.4383 | 0.9545 | 1.0243 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 7813.001 | uM | 5.56960 | 8.06020 | -0.9735 | -1.0000 | 2.9723 | 0.1992 | 0.9944 | 0.7338 | |
| HCC1395 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 7436.091 | uM | inf | inf | -0.9110 | -0.9110 | 0.0000 | 0.2752 | 0.5479 | 1.2489 | |
| HCC1395 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 7435.098 | uM | 3.30950 | 3.29770 | -0.4957 | 0.0088 | 5.0000 | 0.3285 | 0.6442 | 0.7702 | |
| HCC1395 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 7435.091 | uM | 3.60990 | 6.22790 | -1.0000 | -1.0000 | 2.0145 | 0.5103 | 0.9880 | 0.5716 |