Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1395 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 12084.155 | uM | inf | inf | 0.8548 | 0.8548 | 0.0000 | 0.1129 | 0.4499 | 1.2955 | |
| HCC1395 | TNBC | Basal B | Dichloroacetate | PDK | PDK | 13538.176 | uM | inf | inf | 0.8042 | 0.8042 | 0.0000 | 0.1436 | 0.3146 | 0.4572 | |
| HCC1395 | TNBC | Basal B | Disulfiram | Proteasome | Proteasome | 13538.174 | uM | inf | 0.14414 | 0.6866 | 0.6441 | 5.0000 | 0.1678 | 0.7406 | 0.4615 | |
| HCC1395 | TNBC | Basal B | Docetaxel | TUBB | TUBB | 7813.002 | uM | 0.00427 | 0.00565 | -0.3992 | -0.3837 | 2.0301 | 0.8129 | 0.9487 | 0.8463 | |
| HCC1395 | TNBC | Basal B | Docetaxel | TUBB | TUBB | 9254.002 | uM | 0.00740 | 0.00860 | -0.5219 | -0.5591 | 5.0000 | 0.8610 | 0.9829 | 0.3983 | |
| HCC1395 | TNBC | Basal B | Docetaxel | TUBB | TUBB | 9258.002 | uM | 0.00521 | 0.00815 | -0.6370 | -0.6272 | 1.8161 | 0.9088 | 0.9971 | 0.7065 | |
| HCC1395 | TNBC | Basal B | Doxorubicin | TOP2 | TOP | 7816.007 | uM | inf | inf | 0.3187 | 0.3187 | 0.0000 | 0.2775 | 0.3760 | 1.1536 | |
| HCC1395 | TNBC | Basal B | Doxorubicin | TOP2 | TOP | 9258.121 | uM | 0.06051 | 0.20762 | -0.9952 | -0.9809 | 0.8807 | 0.9474 | 0.9235 | 0.4800 | |
| HCC1395 | TNBC | Basal B | Doxorubicin | TOP2 | TOP | 7813.007 | uM | 0.48027 | 1.07560 | -0.9401 | -0.8913 | 1.2692 | 0.6307 | 0.9841 | 0.8361 | |
| HCC1395 | TNBC | Basal B | Doxorubicin | TOP2 | TOP | 9254.121 | uM | 0.26202 | 0.84031 | -0.7184 | -0.7501 | 0.7863 | 0.6266 | 0.9951 | 1.2352 | |
| HCC1395 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 7816.017 | uM | inf | inf | 0.6386 | 0.6386 | 0.0000 | 0.2394 | 0.3980 | 1.2318 | |
| HCC1395 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 7814.017 | uM | 0.11667 | 0.50267 | -0.9999 | -1.0000 | 0.7522 | 0.9106 | 0.9652 | 0.8254 | |
| HCC1395 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 7813.017 | uM | 1.12510 | 2.08510 | -0.9985 | -0.9000 | 1.6689 | 0.6609 | 0.9865 | 0.8685 | |
| HCC1395 | TNBC | Basal B | Erlotinib | EGFR | ErbB | 7435.091 | uM | 9.27430 | 124.03820 | 0.1135 | -1.0000 | 0.4236 | 0.2248 | 0.9537 | 0.5716 | |
| HCC1395 | TNBC | Basal B | Erlotinib | EGFR | ErbB | 7436.091 | uM | inf | 17.23990 | 0.5816 | 0.5613 | 2.2376 | 0.0241 | 0.9542 | 1.2489 | |
| HCC1395 | TNBC | Basal B | Etoposide | TOP2 | TOP | 7435.074 | uM | 1.98140 | 8.66670 | -0.5267 | -0.6831 | 0.5836 | 0.5057 | 0.9852 | 0.8579 | |
| HCC1395 | TNBC | Basal B | Etoposide | TOP2 | TOP | 7436.074 | uM | 4.01870 | 19.69650 | -0.3894 | -0.6771 | 0.5387 | 0.4235 | 0.9934 | 1.2173 | |
| HCC1395 | TNBC | Basal B | Everolimus | MTOR | MTOR | 12000.164 | uM | 5.03670 | 58.66680 | -0.1874 | -1.0000 | 0.4475 | 0.2752 | 0.8710 | 0.7152 | |
| HCC1395 | TNBC | Basal B | Everolimus | MTOR | MTOR | 12084.164 | uM | 11.46740 | 25.82510 | -0.6121 | -1.0000 | 1.3532 | 0.2789 | 0.9089 | 1.2250 | |
| HCC1395 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 7435.084 | uM | 0.27572 | 0.41327 | -0.9997 | -1.0000 | 2.7144 | 0.7084 | 0.9961 | 0.8646 | |
| HCC1395 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 7436.085 | uM | 0.34731 | 0.57214 | -0.9575 | -0.9591 | 2.1456 | 0.6174 | 0.9993 | 1.2621 | |
| HCC1395 | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 12084.161 | uM | 55.24160 | 307.16790 | 0.3259 | -1.0000 | 0.6403 | 0.1626 | 0.7084 | 1.4492 | |
| HCC1395 | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 12000.166 | uM | 9.98610 | 115.93550 | -0.0917 | -1.0000 | 0.4481 | 0.2807 | 0.8131 | 0.7468 | |
| HCC1395 | TNBC | Basal B | FTase Inhibitor I | Ftase | MAPK | 12000.167 | uM | inf | inf | 0.7814 | 0.7814 | 0.0000 | 0.1511 | -0.0746 | 0.7185 | |
| HCC1395 | TNBC | Basal B | FTase Inhibitor I | Ftase | MAPK | 12084.154 | uM | inf | inf | 0.7715 | 0.7715 | 0.0000 | 0.1395 | -0.0309 | 1.2963 |