Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1419 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 10019.049 | uM | 2.99220 | 5.48580 | -0.9159 | -0.9898 | 1.8011 | 0.2683 | 0.9944 | 0.4626 | |
| HCC1419 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 7820.04 | uM | 0.03158 | 0.03905 | -0.5355 | -0.4856 | 3.1934 | 0.8811 | 0.9943 | 0.7382 | |
| HCC1419 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 10019.049 | uM | 0.04194 | 0.05941 | -0.9260 | -0.8573 | 2.8690 | 1.0457 | 0.9977 | 0.4626 | |
| HCC1419 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 9278.012 | uM | 0.01679 | 0.02086 | -0.9931 | -0.9792 | 5.0000 | 1.3182 | 0.9989 | 0.3370 | |
| HCC1419 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 10019.12 | uM | 18.64930 | 0.19440 | 0.4546 | 0.4882 | 0.8207 | 0.2321 | 0.6442 | 0.4898 | |
| HCC1419 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 7819.075 | uM | inf | 0.09211 | 0.5906 | 0.6822 | 4.9999 | 0.2096 | 0.7317 | 0.5386 | |
| HCC1419 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 7820.011 | uM | inf | 0.04746 | 0.6804 | 0.6913 | 5.0000 | 0.2024 | 0.7961 | 0.6709 | |
| HCC1419 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 9278.011 | uM | 0.18669 | 0.03786 | 0.3284 | 0.3647 | 0.8192 | 0.3995 | 0.9202 | 0.5434 | |
| HCC1419 | HER2amp | Luminal | Glycyl-H-1152 | ROCK2 | 12001.169 | uM | 40.64080 | 175.06620 | 0.3387 | -1.0000 | 0.7523 | 0.1415 | 0.7616 | 0.7194 | ||
| HCC1419 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 7819.001 | uM | 4.73720 | 25.60010 | -0.1173 | -1.0000 | 0.6512 | 0.2216 | 0.9155 | 0.4919 | |
| HCC1419 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 7820.001 | uM | 7.71170 | 6.43760 | 0.2975 | 0.2973 | 4.9992 | 0.1058 | 0.9438 | 0.7692 | |
| HCC1419 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 9278.001 | uM | 6.59160 | 6.92790 | -0.1408 | -0.1412 | 5.0000 | 0.1504 | 0.9445 | 0.4429 | |
| HCC1419 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 10019.001 | uM | 6.32170 | 7.28910 | -0.5182 | -0.5189 | 4.9999 | 0.2040 | 0.9453 | 0.3968 | |
| HCC1419 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 7821.001 | uM | 5.54660 | 6.28550 | -0.4340 | -0.4344 | 4.9999 | 0.1813 | 0.9787 | 0.3296 | |
| HCC1419 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 7440.091 | uM | 5.56450 | 8.63270 | -0.6436 | -0.6721 | 1.9400 | 0.4368 | 0.9612 | 0.4250 | |
| HCC1419 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 7440.098 | uM | 13.16870 | 17.2730 | -0.9998 | -1.0000 | 4.0494 | 0.2200 | 0.9863 | 0.3606 | |
| HCC1419 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 7437.091 | uM | 13.70750 | 19.55620 | -0.9980 | -1.0000 | 3.0916 | 0.3125 | 0.9919 | 0.3419 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 9278.001 | uM | inf | inf | -0.2055 | -0.2055 | 0.0000 | 0.1973 | 0.3073 | 0.4429 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 7819.001 | uM | 7.74070 | 8.73220 | -0.4023 | -0.4043 | 4.9164 | 0.1886 | 0.8829 | 0.4919 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 7821.001 | uM | 6.66610 | 8.08760 | -0.8039 | -0.8055 | 4.9650 | 0.2362 | 0.8982 | 0.3296 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 7820.001 | uM | 8.33860 | 9.98310 | -0.7130 | -0.7175 | 4.9438 | 0.1901 | 0.9248 | 0.7692 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 10019.001 | uM | 7.27140 | 9.02660 | -0.9678 | -0.9707 | 4.9898 | 0.1937 | 0.9732 | 0.3968 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 7821.001 | uM | 0.70071 | 8.29840 | -0.6547 | -1.0000 | 0.4445 | 0.3641 | 0.7623 | 0.3296 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 7820.001 | uM | 3.23950 | 103.97390 | 0.0561 | -1.0000 | 0.3167 | 0.2608 | 0.7961 | 0.7692 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 7819.001 | uM | 0.61228 | 12.97960 | -0.4200 | -1.0000 | 0.3597 | 0.3636 | 0.8294 | 0.4919 |