Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1419 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 12001.155 | uM | 0.05548 | 0.05412 | 0.1725 | 0.0583 | 4.9999 | 0.5584 | 0.6612 | 0.5973 | |
| HCC1419 | HER2amp | Luminal | Dichloroacetate | PDK | PDK | 12612.176 | uM | inf | inf | 0.7616 | 0.7616 | 0.0000 | 0.2242 | -0.5439 | 0.6422 | |
| HCC1419 | HER2amp | Luminal | Disulfiram | Proteasome | Proteasome | 12612.174 | uM | inf | inf | 0.5729 | 0.5729 | 0.0000 | 0.1584 | 0.4728 | 0.5962 | |
| HCC1419 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 7820.002 | uM | inf | 0.04980 | 0.6409 | 0.5965 | 2.2116 | 0.1533 | 0.9155 | 0.7084 | |
| HCC1419 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 10019.002 | uM | 0.03102 | 0.02212 | 0.3860 | 0.4078 | 4.9999 | 0.2530 | 0.9570 | 0.3915 | |
| HCC1419 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 9278.002 | uM | 0.01068 | 0.01408 | -0.2346 | -0.2270 | 1.3556 | 0.6466 | 0.9632 | 0.3717 | |
| HCC1419 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 7821.007 | uM | 0.48265 | 0.54754 | -0.8299 | -0.4393 | 4.9979 | 0.7531 | 0.7330 | 0.6838 | |
| HCC1419 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 7820.007 | uM | 0.42291 | 0.63705 | -0.9817 | -0.7623 | 2.2604 | 0.6431 | 0.9842 | 0.6838 | |
| HCC1419 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 9278.121 | uM | 0.46984 | 0.86350 | -1.0000 | -0.9686 | 1.7704 | 0.7017 | 0.9979 | 0.4498 | |
| HCC1419 | HER2amp | Luminal | Epirubicin | TOP2 | TOP | 7820.017 | uM | 0.58010 | 0.98790 | -0.9999 | -0.7987 | 1.7929 | 0.7402 | 0.9646 | 0.6915 | |
| HCC1419 | HER2amp | Luminal | Epirubicin | TOP2 | TOP | 9278.017 | uM | 0.61228 | 0.77480 | -1.0000 | -0.8536 | 4.2304 | 0.7834 | 0.9935 | 0.5453 | |
| HCC1419 | HER2amp | Luminal | Epirubicin | TOP2 | TOP | 7821.017 | uM | 0.78388 | 0.97271 | -1.0000 | -0.9710 | 5.0000 | 0.7996 | 0.9985 | 0.3792 | |
| HCC1419 | HER2amp | Luminal | Erlotinib | EGFR | ErbB | 7440.091 | uM | 6.31940 | 8.43990 | -0.3793 | -0.3997 | 2.0302 | 0.2666 | 0.9548 | 0.4250 | |
| HCC1419 | HER2amp | Luminal | Erlotinib | EGFR | ErbB | 7437.091 | uM | 13.4210 | 14.8080 | -0.3169 | -0.3176 | 4.9998 | 0.1297 | 0.9748 | 0.3419 | |
| HCC1419 | HER2amp | Luminal | Etoposide | TOP2 | TOP | 7440.074 | uM | 56.35720 | 413.51440 | 0.0410 | -1.0000 | 0.5512 | 0.2563 | 0.7601 | 0.4778 | |
| HCC1419 | HER2amp | Luminal | Etoposide | TOP2 | TOP | 7437.074 | uM | 79.41070 | 82.08980 | -0.0892 | -0.0902 | 4.9974 | 0.0631 | 0.9850 | 0.3747 | |
| HCC1419 | HER2amp | Luminal | Everolimus | MTOR | MTOR | 12001.164 | uM | 0.00326 | 0.01325 | -0.6565 | -0.4478 | 0.4563 | 0.9119 | 0.9257 | 0.4690 | |
| HCC1419 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 7437.084 | uM | 0.25725 | 0.39177 | -1.0000 | -1.0000 | 2.6118 | 0.7425 | 0.9852 | 0.4343 | |
| HCC1419 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 12001.166 | uM | 1.55430 | 1000.00000 | 0.0357 | -0.7891 | 0.1465 | 0.4014 | 0.6135 | 0.5565 | |
| HCC1419 | HER2amp | Luminal | FTase Inhibitor I | Ftase | MAPK | 12001.167 | uM | inf | inf | 0.6221 | 0.6221 | 0.0000 | 0.3242 | -0.0115 | 0.5287 | |
| HCC1419 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 9278.132 | uM | 7.6250 | 320.76430 | 0.2421 | -1.0000 | 0.2938 | 0.2269 | 0.6299 | 0.3815 | |
| HCC1419 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 7820.016 | uM | 2.73390 | 5.90550 | -0.9258 | -1.0000 | 1.4265 | 0.4015 | 0.8871 | 0.4466 | |
| HCC1419 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 7818.016 | uM | 3.14170 | 9.22690 | -0.6214 | -1.0000 | 1.0197 | 0.2928 | 0.9658 | 0.9146 | |
| HCC1419 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 7821.016 | uM | 1.03540 | 2.87430 | -0.9194 | -1.0000 | 1.0760 | 0.3518 | 0.9801 | 0.3100 | |
| HCC1419 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 7819.016 | uM | 1.89410 | 5.11130 | -0.8894 | -1.0000 | 1.1067 | 0.2956 | 0.9825 | 0.5331 |