Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

 Full screen view
Filter results: >>>>
Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
HCC1428
HR+
Luminal
 Methotrexate
DHFR
Metabolism
7442.085
uM
inf
inf
 0.8241 0.8241 0.0000 0.1164
0.4226
 0.8237
HCC1428
HR+
Luminal
 Methotrexate
DHFR
Metabolism
7441.084
uM
inf
0.15695
 0.8171 0.8409 5.0000 0.0917
0.7653
 0.8431
HCC1428
HR+
Luminal
 Methotrexate
DHFR
Metabolism
7444.084
uM
inf
0.14480
 0.5406 0.6036 2.1482 0.2447
0.8512
 0.8647
HCC1428
HR+
Luminal
 Methylglyoxal
13173.184
uM
455.78020
1000.00000
 -0.9955 -0.6436 1.0530 0.4592
0.8857
 0.7656
HCC1428
HR+
Luminal
 Methylglyoxal
13107.184
uM
509.5660
1000.00000
 -0.9993 -0.8247 1.4452 0.5248
0.9454
 0.6454
HCC1428
HR+
Luminal
 MG-132
Proteasome
Proteasome
11936.145
uM
0.20784
0.30043
 -0.7977 -0.7729 2.5364 0.7920
0.9917
 0.8451
HCC1428
HR+
Luminal
 MG-132
Proteasome
Proteasome
11936.145
uM
0.20784
0.30043
 -0.7977 -0.7729 2.5364 0.7920
0.9917
 0.8451
HCC1428
HR+
Luminal
 MG-132
Proteasome
Proteasome
10693.145
uM
0.31507
0.39321
 -0.7942 -0.7505 4.1381 0.7302
0.9959
 0.8492
HCC1428
HR+
Luminal
 MG-132
Proteasome
Proteasome
10693.145
uM
0.31507
0.39321
 -0.7942 -0.7505 4.1381 0.7302
0.9959
 0.8492
HCC1428
HR+
Luminal
 Pevonedistat
NAE1
NAE1
11936.135
uM
0.08956
0.07930
 0.0690 0.1045 1.9283 0.5138
0.9103
 0.8584
HCC1428
HR+
Luminal
 Pevonedistat
NAE1
NAE1
10693.148
uM
0.12193
0.06805
 0.1484 0.2057 0.9089 0.4358
0.9633
 0.8983
HCC1428
HR+
Luminal
 Nelfinavir
13107.174
uM
6.83630
23.04480
 -0.1791 -1.0000 0.9041 0.2306
0.9141
 0.6723
HCC1428
HR+
Luminal
 Nilotinib
ABL
nRTK
10693.145
uM
13.06880
9.64330
 0.2012 0.3906 5.0000 0.1556
0.8568
 0.8492
HCC1428
HR+
Luminal
 Nilotinib
ABL
nRTK
11936.145
uM
inf
2.17830
 0.5045 0.5364 5.0000 0.1750
0.8994
 0.8451
HCC1428
HR+
Luminal
 NSC 663284
CDC25
CDC
10693.152
uM
2.26390
3.81220
 -0.9883 -0.9984 2.1063 0.6133
0.9962
 0.8734
HCC1428
HR+
Luminal
 NSC 663284
CDC25
CDC
11936.159
uM
3.61310
4.77640
 -0.9938 -0.9940 3.9217 0.5967
0.9979
 0.7472
HCC1428
HR+
Luminal
 NU6102
CDK1/2
CDK
11936.147
uM
13.55430
24.67870
 -0.7379 -1.0000 1.8333 0.2958
0.9091
 0.9187
HCC1428
HR+
Luminal
 NU6102
CDK1/2
CDK
10693.147
uM
13.11670
21.52680
 -0.8580 -1.0000 2.2176 0.2183
0.9855
 0.8879
HCC1428
HR+
Luminal
 Nutlin 3a
MDM2
MDM2
7442.066
uM
66.31950
365.27530
 0.4848 -1.0000 0.6439 0.0874
0.9219
 0.8481
HCC1428
HR+
Luminal
 Nutlin 3a
MDM2
MDM2
10441.066
uM
26.58940
55.93180
 -0.1366 -1.0000 1.4774 0.1736
0.9280
 1.1591
HCC1428
HR+
Luminal
 Nutlin 3a
MDM2
MDM2
7444.066
uM
40.66630
50.65830
 -0.5968 -0.9999 5.0000 0.1209
0.9714
 0.6972
HCC1428
HR+
Luminal
 Nutlin 3a
MDM2
MDM2
7443.066
uM
22.73520
40.09110
 -0.4593 -1.0000 1.9368 0.1530
0.9799
 0.9414
HCC1428
HR+
Luminal
 Nutlin 3a
MDM2
MDM2
7441.066
uM
16.16680
26.21430
 -0.7870 -1.0000 2.2729 0.1633
0.9954
 0.7593
HCC1428
HR+
Luminal
 Olomoucine II
CDK1
CDK
11936.147
uM
5.2220
9.85010
 -0.5951 -0.6577 1.3230 0.4093
0.9622
 0.9187
HCC1428
HR+
Luminal
 Olomoucine II
CDK1
CDK
10693.147
uM
3.84980
9.03580
 -0.3216 -0.5063 0.8198 0.3367
0.9865
 0.8879