Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1428 | HR+ | Luminal | IKK16 | IKK | NFKB | 7442.1 | uM | 3.40720 | 4.5760 | -0.9894 | -0.9904 | 3.7032 | 0.4440 | 0.9927 | 0.8780 | |
| HCC1428 | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 7444.091 | uM | 16.6760 | 26.68450 | -0.9939 | -1.0000 | 2.3369 | 0.5085 | 0.9930 | 0.8764 | |
| HCC1428 | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 7441.09 | uM | 16.18210 | 26.74840 | -0.9981 | -1.0000 | 2.1860 | 0.4897 | 0.9934 | 0.7331 | |
| HCC1428 | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 7442.092 | uM | 19.2520 | 27.09720 | -0.9971 | -1.0000 | 3.2141 | 0.4724 | 0.9966 | 0.7831 | |
| HCC1428 | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 7443.09 | uM | 18.27640 | 28.08890 | -0.9897 | -1.0000 | 2.5563 | 0.4713 | 0.9983 | 0.9451 | |
| HCC1428 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 7442.067 | uM | 0.24702 | 3.16120 | -0.9871 | -1.0000 | 0.4310 | 0.4769 | 0.7910 | 0.9126 | |
| HCC1428 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 7441.067 | uM | 1.76950 | 6.7880 | -0.9951 | -1.0000 | 0.8171 | 0.3267 | 0.8311 | 0.8233 | |
| HCC1428 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 7444.067 | uM | 0.15890 | 1.56350 | -0.9993 | -1.0000 | 0.4805 | 0.5040 | 0.8779 | 0.7382 | |
| HCC1428 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 7443.067 | uM | 7.49060 | 10.31620 | -0.9841 | -1.0000 | 3.4325 | 0.3014 | 0.9084 | 1.0344 | |
| HCC1428 | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 7444.095 | uM | 0.01732 | 0.72589 | -0.9926 | -1.0000 | 0.2941 | 0.7036 | 0.8142 | 0.8776 | |
| HCC1428 | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 7442.095 | uM | 0.02618 | 0.81312 | -0.9935 | -1.0000 | 0.3197 | 0.6872 | 0.8609 | 0.7851 | |
| HCC1428 | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 7443.094 | uM | 0.61697 | 1.84920 | -0.9920 | -1.0000 | 1.0008 | 0.7800 | 0.9767 | 0.8852 | |
| HCC1428 | HR+ | Luminal | JNK-IN-5A | JNK | JNK | 11936.144 | uM | 2.56140 | 1.96250 | 0.2430 | 0.3680 | 4.9999 | 0.2182 | 0.8223 | 0.8864 | |
| HCC1428 | HR+ | Luminal | JNK-IN-5A | JNK | JNK | 10693.144 | uM | 0.67356 | 0.37760 | 0.5424 | 0.4723 | 5.0000 | 0.2355 | 0.9438 | 0.8585 | |
| HCC1428 | HR+ | Luminal | L-779450 | BRAF | MAPK | 11936.161 | uM | 13.26490 | 22.41770 | -0.6949 | -1.0000 | 2.0937 | 0.1762 | 0.9719 | 0.7410 | |
| HCC1428 | HR+ | Luminal | L-779450 | BRAF | MAPK | 10693.149 | uM | 9.03840 | 8.69690 | 0.0877 | 0.0864 | 4.9274 | 0.0581 | 0.9853 | 0.8714 | |
| HCC1428 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 7443.098 | uM | inf | inf | 0.9399 | 0.9399 | 0.0000 | 0.0425 | 0.0000 | 0.9189 | |
| HCC1428 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 7442.098 | uM | inf | inf | 0.9599 | 0.9599 | 0.0000 | 0.0062 | 0.1962 | 0.8652 | |
| HCC1428 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 7444.098 | uM | inf | inf | 0.5583 | 0.5583 | 0.0000 | 0.1289 | 0.4726 | 0.9681 | |
| HCC1428 | HR+ | Luminal | LBH589 | HDAC | HDAC | 11936.154 | uM | 0.05074 | 0.07168 | -0.9882 | -0.9944 | 3.1688 | 0.9855 | 0.9917 | 0.8259 | |
| HCC1428 | HR+ | Luminal | LBH589 | HDAC | HDAC | 10693.154 | uM | 0.15152 | 0.22481 | -0.9771 | -0.9815 | 2.7533 | 0.8031 | 0.9970 | 0.8696 | |
| HCC1428 | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 11936.154 | uM | 0.18173 | 1.67360 | -0.9419 | -1.0000 | 0.4948 | 0.5639 | 0.9284 | 0.8259 | |
| HCC1428 | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 10693.154 | uM | 0.56184 | 2.85790 | -0.9305 | -1.0000 | 0.6754 | 0.4432 | 0.9615 | 0.8696 | |
| HCC1428 | HR+ | Luminal | Mebendazole | 13107.174 | uM | 66.7120 | 4.08910 | 0.4834 | 0.2783 | 0.2913 | 0.2203 | 0.8115 | 0.6723 | |||
| HCC1428 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 7443.084 | uM | inf | inf | 0.8105 | 0.8105 | 0.0000 | 0.1423 | 0.3953 | 0.9878 |