Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1569 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 7448.084 | uM | inf | 0.07814 | 0.9454 | 0.9628 | 4.9913 | 0.0228 | 0.6789 | 2.8225 | |
| HCC1569 | HER2amp | Basal A | Methylglyoxal | 13500.184 | uM | 556.12310 | 1000.00000 | -0.9238 | -0.7264 | 1.5291 | 0.5020 | 0.9688 | 1.6266 | |||
| HCC1569 | HER2amp | Basal A | Methylglyoxal | 13038.184 | uM | 632.13660 | 1000.00000 | -0.9835 | -0.8849 | 2.2213 | 0.5533 | 0.9831 | 1.1106 | |||
| HCC1569 | HER2amp | Basal A | MG-132 | Proteasome | Proteasome | 14245.189 | uM | 0.19295 | 0.20172 | -0.4258 | -0.0760 | 3.1870 | 0.5750 | 0.7385 | 1.4693 | |
| HCC1569 | HER2amp | Basal A | MG-132 | Proteasome | Proteasome | 14245.189 | uM | 0.19295 | 0.20172 | -0.4258 | -0.0760 | 3.1870 | 0.5750 | 0.7385 | 1.4693 | |
| HCC1569 | HER2amp | Basal A | MG-132 | Proteasome | Proteasome | 12523.17 | uM | 0.27647 | 0.35616 | -0.9387 | -0.9245 | 4.1332 | 0.8145 | 0.9988 | 0.8990 | |
| HCC1569 | HER2amp | Basal A | MG-132 | Proteasome | Proteasome | 12523.17 | uM | 0.27647 | 0.35616 | -0.9387 | -0.9245 | 4.1332 | 0.8145 | 0.9988 | 0.8990 | |
| HCC1569 | HER2amp | Basal A | MG-132 | Proteasome | Proteasome | 10872.145 | uM | 0.13031 | 0.18552 | -0.7385 | -0.7306 | 2.5497 | 0.7881 | 0.9993 | 1.6308 | |
| HCC1569 | HER2amp | Basal A | MG-132 | Proteasome | Proteasome | 10872.145 | uM | 0.13031 | 0.18552 | -0.7385 | -0.7306 | 2.5497 | 0.7881 | 0.9993 | 1.6308 | |
| HCC1569 | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 10872.148 | uM | inf | inf | 0.9391 | 0.9391 | 0.0000 | 0.1233 | 0.0002 | 1.5151 | |
| HCC1569 | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 12523.135 | uM | 2.11670 | 1.33880 | 0.1582 | 0.1069 | 0.5252 | 0.2653 | 0.9225 | 0.8958 | |
| HCC1569 | HER2amp | Basal A | Nelfinavir | 13038.174 | uM | inf | 7.51560 | 0.8956 | 0.8956 | 4.6086 | 0.0039 | 0.6885 | 1.2027 | |||
| HCC1569 | HER2amp | Basal A | Nilotinib | ABL | nRTK | 10872.145 | uM | inf | inf | 1.0423 | 1.0423 | 0.0000 | 0.0067 | 0.0000 | 1.6308 | |
| HCC1569 | HER2amp | Basal A | Nilotinib | ABL | nRTK | 12523.17 | uM | inf | inf | 0.8636 | 0.8636 | 0.0000 | 0.0444 | 0.0000 | 0.8990 | |
| HCC1569 | HER2amp | Basal A | NSC 663284 | CDC25 | CDC | 10872.152 | uM | 2.81980 | 4.65580 | -0.9020 | -0.9178 | 2.0785 | 0.5801 | 0.9909 | 1.5916 | |
| HCC1569 | HER2amp | Basal A | NSC 663284 | CDC25 | CDC | 12523.152 | uM | 5.08010 | 6.32050 | -0.9908 | -0.9907 | 5.0000 | 0.4820 | 0.9979 | 0.8423 | |
| HCC1569 | HER2amp | Basal A | NU6102 | CDK1/2 | CDK | 10872.147 | uM | 22.76790 | 44.65710 | -0.3187 | -1.0000 | 1.6308 | 0.1847 | 0.9547 | 1.6255 | |
| HCC1569 | HER2amp | Basal A | NU6102 | CDK1/2 | CDK | 12523.147 | uM | 19.51060 | 21.16230 | -0.2350 | -0.2399 | 4.8221 | 0.0716 | 0.9921 | 0.9214 | |
| HCC1569 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 7448.066 | uM | 44.07780 | 112.5220 | 0.2947 | -1.0000 | 1.1722 | 0.0909 | 0.9721 | 2.7001 | |
| HCC1569 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 7449.066 | uM | 54.43230 | 92.63770 | 0.4258 | -0.3987 | 1.1027 | 0.0548 | 0.9813 | 1.9622 | |
| HCC1569 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 10442.066 | uM | 34.35180 | 50.63960 | -0.3326 | -0.9564 | 2.7548 | 0.1175 | 0.9908 | 1.6519 | |
| HCC1569 | HER2amp | Basal A | Nutlin 3a | MDM2 | MDM2 | 7447.066 | uM | 23.62940 | 31.38530 | -0.1618 | -0.4031 | 2.0830 | 0.0771 | 0.9942 | 1.5813 | |
| HCC1569 | HER2amp | Basal A | Olomoucine II | CDK1 | CDK | 10872.147 | uM | 4.94960 | 6.61530 | -0.1670 | -0.2225 | 1.2690 | 0.3203 | 0.9846 | 1.6255 | |
| HCC1569 | HER2amp | Basal A | Olomoucine II | CDK1 | CDK | 12523.147 | uM | 5.58910 | 5.56240 | 0.0025 | 0.0117 | 4.9695 | 0.2276 | 0.9943 | 0.9214 | |
| HCC1569 | HER2amp | Basal A | Omipalisib | PI3K | PI3K | 10442.087 | uM | 0.01937 | 0.02358 | -0.1923 | -0.1632 | 1.4348 | 0.6440 | 0.9963 | 1.5727 |