Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1569 | HER2amp | Basal A | Ibandronate | FDPS | 10872.143 | uM | 77.75420 | 85.66350 | -0.0844 | -0.0975 | 1.8383 | 0.2571 | 0.9926 | 1.6364 | ||
| HCC1569 | HER2amp | Basal A | Ibandronate | FDPS | 12523.143 | uM | 47.95440 | 57.11140 | -0.1947 | -0.1915 | 1.8551 | 0.3098 | 0.9957 | 0.9700 | ||
| HCC1569 | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 12523.157 | uM | inf | 0.25973 | 0.5245 | 0.5330 | 0.6717 | 0.2131 | 0.8511 | 0.9728 | |
| HCC1569 | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 10872.151 | uM | inf | 0.62613 | 0.6485 | 0.6648 | 1.9039 | 0.1111 | 0.9728 | 1.4028 | |
| HCC1569 | HER2amp | Basal A | IKK16 | IKK | NFKB | 10442.093 | uM | 3.07820 | 4.03890 | -0.9075 | -0.9124 | 3.8228 | 0.4353 | 0.9954 | 1.6861 | |
| HCC1569 | HER2amp | Basal A | Imatinib | ABL/KIT/PDGFR | nRTK | 7447.09 | uM | 20.5810 | 32.34610 | -0.9395 | -0.9705 | 2.3859 | 0.4703 | 0.9936 | 1.5863 | |
| HCC1569 | HER2amp | Basal A | Imatinib | ABL/KIT/PDGFR | nRTK | 7449.091 | uM | 21.74840 | 36.43870 | -0.9499 | -0.9669 | 2.0855 | 0.4253 | 0.9978 | 1.8158 | |
| HCC1569 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 7449.067 | uM | 0.64429 | 4.76340 | -0.9224 | -1.0000 | 0.5492 | 0.3961 | 0.8244 | 1.9771 | |
| HCC1569 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 7448.067 | uM | 1.41230 | 9.14860 | -0.6605 | -1.0000 | 0.5880 | 0.3328 | 0.8528 | 2.8462 | |
| HCC1569 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 7447.067 | uM | 0.21689 | 2.17950 | -0.9405 | -1.0000 | 0.4761 | 0.4785 | 0.8717 | 1.5637 | |
| HCC1569 | HER2amp | Basal A | Ixabepilone | TUBB | TUBB | 7449.095 | uM | 0.26357 | 4.34830 | -0.9190 | -1.0000 | 0.3919 | 0.4848 | 0.7776 | 2.0118 | |
| HCC1569 | HER2amp | Basal A | Ixabepilone | TUBB | TUBB | 7448.095 | uM | 1.03750 | 1.57340 | -0.6271 | -0.6479 | 1.9958 | 0.4145 | 0.9989 | 2.9105 | |
| HCC1569 | HER2amp | Basal A | JNK-IN-5A | JNK | JNK | 10872.144 | uM | inf | 1.49410 | 0.5853 | 0.6038 | 5.0000 | 0.1066 | 0.8812 | 1.5447 | |
| HCC1569 | HER2amp | Basal A | JNK-IN-5A | JNK | JNK | 12523.168 | uM | 181.2820 | 394.94170 | 0.4453 | -1.0000 | 1.4108 | 0.0424 | 0.9629 | 0.9035 | |
| HCC1569 | HER2amp | Basal A | L-779450 | BRAF | MAPK | 10872.149 | uM | 27.96550 | 80.75060 | 0.4188 | -1.0000 | 1.0360 | 0.0885 | 0.8775 | 1.5861 | |
| HCC1569 | HER2amp | Basal A | L-779450 | BRAF | MAPK | 12523.166 | uM | 21.11540 | 87.52230 | 0.3565 | -0.9993 | 0.7723 | 0.1173 | 0.8801 | 0.9938 | |
| HCC1569 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 7449.098 | uM | inf | 1.30230 | 0.5134 | 0.5127 | 2.2836 | 0.0692 | 0.9711 | 1.8675 | |
| HCC1569 | HER2amp | Basal A | Lapatinib | EGFR/HER2 | ErbB | 7448.098 | uM | inf | 1.58780 | 0.5823 | 0.5787 | 2.1102 | 0.0714 | 0.9827 | 2.8877 | |
| HCC1569 | HER2amp | Basal A | LBH589 | HDAC | HDAC | 12523.167 | uM | 0.16215 | 0.39146 | -0.8745 | -0.9056 | 1.1728 | 0.6848 | 0.9951 | 1.0398 | |
| HCC1569 | HER2amp | Basal A | LBH589 | HDAC | HDAC | 10872.154 | uM | 0.14661 | 0.25243 | -0.7895 | -0.7709 | 1.7170 | 0.6493 | 0.9982 | 1.3976 | |
| HCC1569 | HER2amp | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 12523.167 | uM | 0.48896 | 2.16390 | -0.9582 | -1.0000 | 0.7386 | 0.4486 | 0.9212 | 1.0398 | |
| HCC1569 | HER2amp | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 10872.154 | uM | 0.91512 | 3.12840 | -0.9168 | -1.0000 | 0.8938 | 0.3572 | 0.9778 | 1.3976 | |
| HCC1569 | HER2amp | Basal A | Mebendazole | 13038.174 | uM | 5.71160 | 321.540 | 0.1984 | -0.9828 | 0.2697 | 0.2801 | 0.8599 | 1.2027 | |||
| HCC1569 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 7449.084 | uM | inf | inf | 0.9327 | 0.9327 | 0.0000 | 0.0427 | 0.0247 | 2.1410 | |
| HCC1569 | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 7447.084 | uM | inf | inf | 0.9665 | 0.9665 | 0.0000 | -0.0028 | 0.1708 | 1.5152 |