Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1569 | HER2amp | Basal A | Fascaplysin | CDK4 | CDK | 7447.084 | uM | 0.31318 | 0.44187 | -0.9554 | -0.9331 | 3.0589 | 0.6357 | 0.9986 | 1.5152 | |
| HCC1569 | HER2amp | Basal A | Fascaplysin | CDK4 | CDK | 7448.084 | uM | 0.62742 | 0.95935 | -0.6649 | -0.6402 | 1.9412 | 0.4480 | 0.9995 | 2.8225 | |
| HCC1569 | HER2amp | Basal A | FR180204 | ERK1/2 | MAPK | 12523.166 | uM | inf | inf | 0.8187 | 0.8187 | 0.0000 | 0.0369 | -0.0038 | 0.9938 | |
| HCC1569 | HER2amp | Basal A | FR180204 | ERK1/2 | MAPK | 10872.149 | uM | inf | 999.99120 | 0.8442 | 0.5953 | 0.1443 | 0.0834 | 0.7340 | 1.5861 | |
| HCC1569 | HER2amp | Basal A | FTase Inhibitor I | Ftase | MAPK | 10872.154 | uM | inf | inf | 1.0039 | 1.0039 | 0.0000 | -0.0388 | -3.1523 | 1.3976 | |
| HCC1569 | HER2amp | Basal A | FTase Inhibitor I | Ftase | MAPK | 12523.167 | uM | inf | inf | 0.9196 | 0.9196 | 0.0000 | 0.0504 | 0.2977 | 1.0398 | |
| HCC1569 | HER2amp | Basal A | Gefitinib | EGFR | ErbB | 9347.132 | uM | inf | inf | 0.7135 | 0.7135 | 0.0000 | 0.1089 | 0.4391 | 1.4716 | |
| HCC1569 | HER2amp | Basal A | Gefitinib | EGFR | ErbB | 7827.016 | uM | 18.17670 | 1000.00000 | 0.3340 | -0.7967 | 0.2378 | 0.2206 | 0.6184 | 1.4950 | |
| HCC1569 | HER2amp | Basal A | Gefitinib | EGFR | ErbB | 7825.016 | uM | 6.57890 | 39.06610 | 0.0456 | -1.0000 | 0.6167 | 0.1713 | 0.9897 | 1.6601 | |
| HCC1569 | HER2amp | Basal A | Gefitinib | EGFR | ErbB | 7824.016 | uM | 6.50910 | 15.29610 | -0.4694 | -1.0000 | 1.2858 | 0.1893 | 0.9928 | 1.7164 | |
| HCC1569 | HER2amp | Basal A | Geldanamycin | HSP90 | HSP90 | 9347.012 | uM | 0.04237 | 0.04671 | -0.2624 | -0.1348 | 2.4475 | 0.6488 | 0.9886 | 1.4653 | |
| HCC1569 | HER2amp | Basal A | Gemcitabine | DNA replication | DNA replication | 9347.011 | uM | 72.98540 | 0.20392 | 0.4633 | 0.4679 | 0.4669 | 0.2665 | 0.9536 | 1.6648 | |
| HCC1569 | HER2amp | Basal A | Gemcitabine | DNA replication | DNA replication | 7825.011 | uM | 0.56298 | 0.06204 | 0.3224 | 0.2783 | 0.3687 | 0.4210 | 0.9789 | 1.9334 | |
| HCC1569 | HER2amp | Basal A | Glycyl-H-1152 | ROCK2 | 10872.15 | uM | 8.16020 | 63.35940 | 0.1713 | -1.0000 | 0.5360 | 0.1856 | 0.9434 | 1.6255 | ||
| HCC1569 | HER2amp | Basal A | Glycyl-H-1152 | ROCK2 | 12523.169 | uM | 5.76590 | 5.65180 | 0.0536 | 0.0104 | 1.0511 | 0.1931 | 0.9614 | 1.0498 | ||
| HCC1569 | HER2amp | Basal A | GSK1070916 | AURK | AURK | 7825.001 | uM | 0.64893 | 4.17490 | -0.7698 | -1.0000 | 0.5902 | 0.4203 | 0.9327 | 1.5991 | |
| HCC1569 | HER2amp | Basal A | GSK1070916 | AURK | AURK | 9347.001 | uM | 1.42620 | 8.85950 | -0.5083 | -1.0000 | 0.6015 | 0.3327 | 0.9368 | 1.5003 | |
| HCC1569 | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 7448.098 | uM | inf | 2.96210 | 0.6790 | 0.7682 | 5.0000 | 0.0632 | 0.8119 | 2.8877 | |
| HCC1569 | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 7447.09 | uM | 11.72570 | 113.36850 | -0.0442 | -1.0000 | 0.4842 | 0.2560 | 0.9866 | 1.5863 | |
| HCC1569 | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 7449.098 | uM | 7.4310 | 6.64670 | 0.1483 | 0.1478 | 3.1407 | 0.1310 | 0.9919 | 1.8675 | |
| HCC1569 | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 7449.091 | uM | 5.76140 | 6.77170 | -0.6792 | -0.6216 | 5.0000 | 0.3703 | 0.9949 | 1.8158 | |
| HCC1569 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 7825.001 | uM | 0.15256 | 15.33320 | -0.3253 | -1.0000 | 0.2383 | 0.4731 | 0.7760 | 1.5991 | |
| HCC1569 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 9347.001 | uM | 1.62850 | 35.85340 | -0.0931 | -1.0000 | 0.3553 | 0.2866 | 0.8496 | 1.5003 | |
| HCC1569 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 7825.001 | uM | 0.41610 | 0.42593 | 0.0315 | -0.0048 | 0.4067 | 0.3494 | 0.8917 | 1.5991 | |
| HCC1569 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 9347.001 | uM | 0.26176 | 0.11556 | 0.1814 | 0.3781 | 1.7267 | 0.2532 | 0.9231 | 1.5003 |