Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1428 | HR+ | Luminal | Docetaxel | TUBB | TUBB | 10031.002 | uM | inf | 0.01129 | 0.5669 | 0.5754 | 1.0719 | 0.2081 | 0.9236 | 0.6483 | |
| HCC1428 | HR+ | Luminal | Docetaxel | TUBB | TUBB | 9294.002 | uM | 0.01312 | 0.00515 | 0.3113 | 0.3127 | 1.0488 | 0.3931 | 0.9892 | 0.7467 | |
| HCC1428 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 10031.034 | uM | 1.05840 | 1.42520 | -0.9868 | -0.9247 | 3.5196 | 0.5885 | 0.9979 | 0.8064 | |
| HCC1428 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 9294.121 | uM | 1.53130 | 1.90130 | -0.9855 | -0.9758 | 5.0000 | 0.5808 | 0.9981 | 0.7502 | |
| HCC1428 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 9299.121 | uM | 1.1540 | 1.4370 | -0.9998 | -0.9965 | 4.9988 | 0.6129 | 0.9986 | 0.4126 | |
| HCC1428 | HR+ | Luminal | Epirubicin | TOP2 | TOP | 9294.017 | uM | 1.25510 | 1.74180 | -0.9994 | -0.9690 | 3.2891 | 0.6721 | 0.9982 | 0.8160 | |
| HCC1428 | HR+ | Luminal | Erlotinib | EGFR | ErbB | 7441.09 | uM | 25.84140 | 15.13410 | 0.4658 | 0.4655 | 4.9981 | 0.0390 | 0.9559 | 0.7331 | |
| HCC1428 | HR+ | Luminal | Erlotinib | EGFR | ErbB | 7444.091 | uM | 17.60170 | 12.14180 | 0.2742 | 0.2340 | 1.6998 | 0.1089 | 0.9811 | 0.8764 | |
| HCC1428 | HR+ | Luminal | Erlotinib | EGFR | ErbB | 7443.09 | uM | 16.16380 | 13.92440 | 0.2626 | 0.2623 | 4.9872 | 0.0947 | 0.9816 | 0.9451 | |
| HCC1428 | HR+ | Luminal | Erlotinib | EGFR | ErbB | 7442.092 | uM | 20.36120 | 44.17660 | 0.1965 | -1.0000 | 1.4184 | 0.0644 | 0.9847 | 0.7831 | |
| HCC1428 | HR+ | Luminal | Etoposide | TOP2 | TOP | 7441.074 | uM | 25.08420 | 44.24390 | -0.2579 | -0.4169 | 1.0686 | 0.2852 | 0.9595 | 0.8339 | |
| HCC1428 | HR+ | Luminal | Etoposide | TOP2 | TOP | 7443.074 | uM | 40.11810 | 74.39380 | -0.1016 | -0.3829 | 0.9207 | 0.2127 | 0.9877 | 0.8753 | |
| HCC1428 | HR+ | Luminal | Etoposide | TOP2 | TOP | 7442.074 | uM | 35.2970 | 58.73220 | -0.5752 | -0.6638 | 1.6592 | 0.2249 | 0.9974 | 0.8143 | |
| HCC1428 | HR+ | Luminal | Etoposide | TOP2 | TOP | 7444.074 | uM | 23.30610 | 44.39780 | -0.5476 | -0.6583 | 1.3036 | 0.2538 | 0.9977 | 0.7602 | |
| HCC1428 | HR+ | Luminal | Everolimus | MTOR | MTOR | 11936.164 | uM | 0.89547 | 9.01190 | -0.9565 | -1.0000 | 0.4758 | 0.4572 | 0.7769 | 0.8717 | |
| HCC1428 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 7442.085 | uM | 0.00643 | 0.01886 | -0.9964 | -1.0000 | 1.0202 | 1.1658 | 0.9946 | 0.8237 | |
| HCC1428 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 7443.084 | uM | 0.04270 | 0.06297 | -0.9890 | -0.9919 | 2.8139 | 0.9929 | 0.9973 | 0.9878 | |
| HCC1428 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 7444.084 | uM | 0.02965 | 0.04679 | -0.9954 | -0.9959 | 2.4028 | 1.0317 | 0.9992 | 0.8647 | |
| HCC1428 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 7441.084 | uM | 0.04994 | 0.06216 | -0.9976 | -0.9943 | 5.0000 | 0.9412 | 0.9996 | 0.8431 | |
| HCC1428 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 10693.149 | uM | inf | inf | 0.9231 | 0.9231 | 0.0000 | -0.0023 | 0.5446 | 0.8714 | |
| HCC1428 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 11936.161 | uM | 34.29240 | 24.3660 | 0.4098 | 0.4093 | 4.9957 | 0.0700 | 0.8973 | 0.7410 | |
| HCC1428 | HR+ | Luminal | FTase Inhibitor I | Ftase | MAPK | 10693.154 | uM | inf | inf | 0.9040 | 0.9040 | 0.0000 | 0.0850 | -0.1383 | 0.8696 | |
| HCC1428 | HR+ | Luminal | FTase Inhibitor I | Ftase | MAPK | 11936.154 | uM | inf | inf | 0.7906 | 0.7906 | 0.0000 | 0.1423 | -0.0917 | 0.8259 | |
| HCC1428 | HR+ | Luminal | Gefitinib | EGFR | ErbB | 9294.019 | uM | 8.8980 | 13.36810 | -0.8460 | -1.0000 | 2.6990 | 0.2414 | 0.9608 | 0.8608 | |
| HCC1428 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 10031.012 | uM | 0.02610 | 0.02690 | -0.1006 | -0.0817 | 4.9980 | 0.6907 | 0.9950 | 0.7110 |