Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

 Full screen view
Filter results: >>>>
Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
HCC1428
HR+
Luminal
 Bortezomib
Proteasome
Proteasome
7444.074
uM
0.31135
0.72011
 -0.7159 -0.6504 0.9937 0.6798
0.9853
 0.7602
HCC1428
HR+
Luminal
 Bortezomib
Proteasome
Proteasome
7444.074
uM
0.31135
0.72011
 -0.7159 -0.6504 0.9937 0.6798
0.9853
 0.7602
HCC1428
HR+
Luminal
 Bortezomib
Proteasome
Proteasome
7442.074
uM
0.14851
0.30963
 -0.8354 -0.7009 1.1926 0.8244
0.9862
 0.8143
HCC1428
HR+
Luminal
 Bortezomib
Proteasome
Proteasome
7442.074
uM
0.14851
0.30963
 -0.8354 -0.7009 1.1926 0.8244
0.9862
 0.8143
HCC1428
HR+
Luminal
 Bortezomib
Proteasome
Proteasome
7443.074
uM
0.50296
0.97614
 -0.4605 -0.4128 0.9078 0.5516
0.9884
 0.8753
HCC1428
HR+
Luminal
 Bortezomib
Proteasome
Proteasome
7443.074
uM
0.50296
0.97614
 -0.4605 -0.4128 0.9078 0.5516
0.9884
 0.8753
HCC1428
HR+
Luminal
 Bortezomib
Proteasome
Proteasome
7441.074
uM
0.17845
0.39955
 -0.6465 -0.5636 0.9364 0.7364
0.9885
 0.8339
HCC1428
HR+
Luminal
 Bortezomib
Proteasome
Proteasome
7441.074
uM
0.17845
0.39955
 -0.6465 -0.5636 0.9364 0.7364
0.9885
 0.8339
HCC1428
HR+
Luminal
 Bosutinib
Src
nRTK
11936.145
uM
4.27540
7.86210
 -0.7174 -0.7901 1.5560 0.4509
0.9386
 0.8451
HCC1428
HR+
Luminal
 Bosutinib
Src
nRTK
10693.145
uM
2.7610
5.72950
 -0.9912 -1.0000 1.5049 0.5196
0.9752
 0.8492
HCC1428
HR+
Luminal
 Carboplatin
DNA cross-linker
DNA cross-linker
10031.021
uM
135.23960
237.17580
 -0.8861 -0.9550 1.9014 0.2373
0.9966
 0.8450
HCC1428
HR+
Luminal
 Carboplatin
DNA cross-linker
DNA cross-linker
9294.011
uM
129.67070
224.20670
 -0.9666 -1.0000 2.0063 0.2810
0.9978
 0.7255
HCC1428
HR+
Luminal
 Cetuximab
EGFR
ErbB
9294.125
uM
inf
inf
 0.8816 0.8816 0.0000 0.0595
-0.0071
 0.6999
HCC1428
HR+
Luminal
 Cetuximab
EGFR
ErbB
7441.102
uM
inf
inf
 0.9761 0.9761 0.0000 0.0202
0.1949
 0.9144
HCC1428
HR+
Luminal
 CGC-11047
Polyamine analogue
9294.125
uM
7.85540
188.17780
 -0.9981 -1.0000 0.3459 0.6264
0.7950
 0.6999
HCC1428
HR+
Luminal
 CGC-11047
Polyamine analogue
10031.034
uM
180.63980
547.45130
 -0.9933 -1.0000 0.9908 0.4737
0.9029
 0.8064
HCC1428
HR+
Luminal
 Cisplatin
DNA cross-linker
DNA cross-linker
10031.021
uM
44.39150
54.72210
 -0.9223 -0.9233 5.0000 0.2206
0.9924
 0.8450
HCC1428
HR+
Luminal
 Cisplatin
DNA cross-linker
DNA cross-linker
9294.017
uM
21.27720
26.47560
 -0.9792 -0.9915 5.0000 0.3391
0.9976
 0.8160
HCC1428
HR+
Luminal
 CPT-11
TOP1
TOP
10031.034
uM
21.88210
39.25110
 -0.5356 -1.0000 1.8802 0.1098
0.9914
 0.8064
HCC1428
HR+
Luminal
 CPT-11
TOP1
TOP
9299.121
uM
25.43180
41.00050
 -0.6885 -1.0000 2.3004 0.1113
0.9914
 0.4126
HCC1428
HR+
Luminal
 CPT-11
TOP1
TOP
9294.121
uM
16.54340
19.70270
 -0.6969 -0.6981 5.0000 0.1689
0.9925
 0.7502
HCC1428
HR+
Luminal
 Dactolisib
PI3K
PI3K
10693.146
uM
inf
inf
 0.8694 0.8694 0.0000 0.0769
0.2636
 0.8826
HCC1428
HR+
Luminal
 Dactolisib
PI3K
PI3K
11936.155
uM
0.29567
0.26124
 0.4454 0.2308 5.0000 0.3296
0.5944
 0.7332
HCC1428
HR+
Luminal
 Dichloroacetate
PDK
PDK
13107.176
uM
inf
inf
 0.7183 0.7183 0.0000 0.1424
0.4407
 0.6790
HCC1428
HR+
Luminal
 Disulfiram
Proteasome
Proteasome
13107.174
uM
0.22485
0.12349
 0.1983 0.4750 4.9997 0.2663
0.6631
 0.6723