Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1395 | TNBC | Basal B | SB-3CT | MMP2/9 | MMP | 12084.144 | uM | 73.76390 | 626.40640 | 0.4245 | -1.0000 | 0.5136 | 0.1446 | 0.7532 | 1.4700 | |
| HCC1395 | TNBC | Basal B | Selumetinib | MEK | MAPK | 12084.155 | uM | inf | inf | 0.8393 | 0.8393 | 0.0000 | 0.0192 | 0.4837 | 1.2955 | |
| HCC1395 | TNBC | Basal B | Selumetinib | MEK | MAPK | 12000.155 | uM | 80.75220 | 1000.00000 | 0.4143 | -0.2078 | 0.1381 | 0.2711 | 0.5795 | 0.8592 | |
| HCC1395 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 12000.165 | uM | 3.01750 | 8.41350 | -0.9985 | -1.0000 | 1.0714 | 0.3839 | 0.9739 | 0.6978 | |
| HCC1395 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 12084.158 | uM | 9.55270 | 16.05570 | -0.9851 | -1.0000 | 2.1158 | 0.2902 | 0.9749 | 1.2976 | |
| HCC1395 | TNBC | Basal B | Sirolimus | MTOR | MTOR | 7815.068 | uM | 0.33863 | 17.8570 | -0.6440 | -1.0000 | 0.2771 | 0.5446 | 0.7812 | 0.3490 | |
| HCC1395 | TNBC | Basal B | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7435.084 | uM | inf | inf | 0.8055 | 0.8055 | 0.0000 | 0.0826 | 0.0062 | 0.8646 | |
| HCC1395 | TNBC | Basal B | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7436.085 | uM | 50.84190 | 63.00890 | -0.9613 | -0.9617 | 5.0000 | 0.2367 | 0.9976 | 1.2621 | |
| HCC1395 | TNBC | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7435.067 | uM | inf | inf | -0.9999 | -0.9999 | 0.0000 | 0.3882 | 0.4920 | 0.7691 | |
| HCC1395 | TNBC | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7436.067 | uM | 6.28170 | 9.30690 | -0.9870 | -0.9914 | 2.7800 | 0.4448 | 0.9986 | 1.2834 | |
| HCC1395 | TNBC | Basal B | TAPI-0 | TACE/Collagenase | 7436.096 | uM | inf | 1.39810 | 0.7383 | 0.7555 | 5.0000 | 0.0724 | 0.8656 | 1.3979 | ||
| HCC1395 | TNBC | Basal B | Taxol | TUBB | TUBB | 7813.002 | uM | 0.01747 | 0.02423 | -0.4841 | -0.4403 | 1.9311 | 0.8608 | 0.9310 | 0.8463 | |
| HCC1395 | TNBC | Basal B | Taxol | TUBB | TUBB | 9254.002 | uM | 0.02485 | 0.02967 | -0.9237 | -0.7129 | 5.0000 | 0.9198 | 0.9866 | 0.3983 | |
| HCC1395 | TNBC | Basal B | Taxol | TUBB | TUBB | 9258.002 | uM | 0.00994 | 0.01669 | -0.7912 | -0.7141 | 1.7129 | 1.0122 | 0.9961 | 0.7065 | |
| HCC1395 | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 12000.159 | uM | 0.07351 | 0.25344 | -0.9026 | -0.8763 | 0.8181 | 0.7327 | 0.9820 | 0.9695 | |
| HCC1395 | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 12084.159 | uM | 0.12645 | 0.46266 | -0.9712 | -1.0000 | 0.8469 | 0.6667 | 0.9938 | 1.2294 | |
| HCC1395 | TNBC | Basal B | TCS PIM-1 1 | Pim kinase | PIM | 12084.135 | uM | inf | inf | 0.7668 | 0.7668 | 0.0000 | 0.1076 | 0.3172 | 1.4162 | |
| HCC1395 | TNBC | Basal B | TCS PIM-1 1 | Pim kinase | PIM | 12000.135 | uM | 64.49110 | 29.37550 | 0.4905 | 0.4902 | 4.9993 | 0.0955 | 0.7497 | 0.6914 | |
| HCC1395 | TNBC | Basal B | Temsirolimus | MTOR | MTOR | 12000.168 | uM | 4.0130 | 18.40320 | -0.9948 | -1.0000 | 0.7214 | 0.4420 | 0.8575 | 0.7873 | |
| HCC1395 | TNBC | Basal B | Temsirolimus | MTOR | MTOR | 12084.144 | uM | 24.82360 | 38.21160 | -0.9756 | -1.0000 | 2.5470 | 0.3146 | 0.9202 | 1.4700 | |
| HCC1395 | TNBC | Basal B | Topotecan | TOP1 | TOP | 9258.121 | uM | 0.00349 | 0.01125 | -0.9927 | -0.9212 | 0.8921 | 1.3529 | 0.9299 | 0.4800 | |
| HCC1395 | TNBC | Basal B | Topotecan | TOP1 | TOP | 7813.007 | uM | 0.01486 | 0.14163 | -0.8539 | -0.9671 | 0.4774 | 1.0047 | 0.9544 | 0.8361 | |
| HCC1395 | TNBC | Basal B | Topotecan | TOP1 | TOP | 7816.007 | uM | 0.00871 | 0.04726 | -0.6908 | -0.6747 | 0.5051 | 0.9894 | 0.9549 | 1.1536 | |
| HCC1395 | TNBC | Basal B | Topotecan | TOP1 | TOP | 9254.121 | uM | 0.01853 | 0.07031 | -0.6563 | -0.6590 | 0.6304 | 0.9209 | 0.9597 | 1.2352 | |
| HCC1395 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 12000.169 | uM | 2.54270 | 8.67140 | -0.9866 | -1.0000 | 0.8955 | 0.4942 | 0.9205 | 0.8565 |