Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1187 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 10753.087 | uM | 0.00781 | 0.11198 | -0.7496 | -0.8691 | 0.3783 | 0.8322 | 0.9577 | 1.4150 | |
| HCC1187 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 10518.087 | uM | 0.00488 | 0.02658 | -0.7747 | -0.7029 | 0.5176 | 0.9208 | 0.9758 | 1.1688 | |
| HCC1187 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 7431.087 | uM | 0.00598 | 0.03287 | -0.9178 | -0.9240 | 0.6143 | 1.0229 | 0.9965 | 1.4117 | |
| HCC1187 | TNBC | Basal A | Oxaliplatin | DNA cross-linker | DNA cross-linker | 7811.011 | uM | 0.26894 | 0.77535 | -1.0000 | -1.0000 | 1.0376 | 1.1173 | 0.9558 | 0.4400 | |
| HCC1187 | TNBC | Basal A | Oxaliplatin | DNA cross-linker | DNA cross-linker | 7812.011 | uM | 1.3180 | 3.08130 | -0.9863 | -0.9483 | 1.2523 | 0.7877 | 0.9956 | 1.0620 | |
| HCC1187 | TNBC | Basal A | Oxaliplatin | DNA cross-linker | DNA cross-linker | 9244.021 | uM | 2.44470 | 3.04470 | -0.9997 | -0.9980 | 5.0000 | 0.8270 | 0.9985 | 0.4542 | |
| HCC1187 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 10753.147 | uM | 0.64075 | 1.52210 | -0.9518 | -0.9833 | 1.2568 | 0.5945 | 0.9948 | 1.2493 | |
| HCC1187 | TNBC | Basal A | PD 98059 | MEK | MAPK | 10753.152 | uM | 3.02630 | 80.71050 | 0.0736 | -1.0000 | 0.3346 | 0.2977 | 0.9487 | 1.3690 | |
| HCC1187 | TNBC | Basal A | PD 98059 | MEK | MAPK | 10518.136 | uM | 5.70580 | 6.65780 | -0.0226 | -0.0746 | 0.9009 | 0.2276 | 0.9698 | 1.2490 | |
| HCC1187 | TNBC | Basal A | PD173074 | FGFR1/3 | RTK | 10518.1 | uM | 11.85830 | 18.21780 | -0.9484 | -1.0000 | 2.5586 | 0.2835 | 0.9690 | 1.4056 | |
| HCC1187 | TNBC | Basal A | PD173074 | FGFR1/3 | RTK | 7431.1 | uM | 11.70780 | 18.80630 | -0.9046 | -1.0000 | 2.3180 | 0.2116 | 0.9980 | 1.5594 | |
| HCC1187 | TNBC | Basal A | PD184352 | MEK | MAPK | 7812.029 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0727 | 0.0526 | 0.9642 | |
| HCC1187 | TNBC | Basal A | PD184352 | MEK | MAPK | 7812.029 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0727 | 0.0526 | 0.9642 | |
| HCC1187 | TNBC | Basal A | PD184352 | MEK | MAPK | 10753.146 | uM | inf | inf | 0.7681 | 0.7681 | 0.0000 | 0.1159 | 0.2362 | 1.4503 | |
| HCC1187 | TNBC | Basal A | PD184352 | MEK | MAPK | 10753.146 | uM | inf | inf | 0.7681 | 0.7681 | 0.0000 | 0.1159 | 0.2362 | 1.4503 | |
| HCC1187 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7433.095 | uM | inf | inf | 0.2099 | 0.2099 | 0.0000 | 0.6689 | 0.1148 | 0.9260 | |
| HCC1187 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7432.095 | uM | inf | inf | 1.0222 | 1.0222 | 0.0000 | 0.0161 | 0.1254 | 0.8368 | |
| HCC1187 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7431.095 | uM | inf | inf | 0.5824 | 0.5824 | 0.0000 | 0.2553 | 0.5276 | 1.2776 | |
| HCC1187 | TNBC | Basal A | PS-1145 | IKK | NFKB | 7433.065 | uM | inf | 1000.00000 | 0.6429 | 0.4284 | 0.5172 | 0.0654 | 0.7671 | 0.8820 | |
| HCC1187 | TNBC | Basal A | PS-1145 | IKK | NFKB | 7432.065 | uM | 3427.84650 | 1000.00000 | 0.5758 | 0.3739 | 1.1179 | 0.0234 | 0.9259 | 0.7981 | |
| HCC1187 | TNBC | Basal A | PS-1145 | IKK | NFKB | 7431.065 | uM | inf | 144.79520 | 0.5837 | 0.5461 | 1.1241 | 0.0908 | 0.9332 | 1.4650 | |
| HCC1187 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 7433.067 | uM | 9.47940 | 10.1330 | -0.8740 | -0.1978 | 5.0000 | 0.2638 | 0.7081 | 1.0142 | |
| HCC1187 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 7432.067 | uM | 22.79160 | 21.31010 | 0.0795 | 0.0553 | 1.7444 | 0.1425 | 0.9753 | 1.0373 | |
| HCC1187 | TNBC | Basal A | Ribavirin | 15300.211 | uM | 48.18310 | 61.54250 | 0.4912 | -0.1113 | 0.8215 | 0.1121 | 0.6468 | 0.8961 | |||
| HCC1187 | TNBC | Basal A | Ro 32-0432 | PKC | PKC | 10518.142 | uM | inf | inf | 0.9965 | 0.9965 | 0.0000 | 0.0075 | 0.0002 | 1.2869 |