Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1187 | TNBC | Basal A | SB-3CT | MMP2/9 | MMP | 10753.144 | uM | 16.84150 | 27.45860 | -0.9211 | -1.0000 | 2.2474 | 0.2310 | 0.9932 | 1.3008 | |
| HCC1187 | TNBC | Basal A | Selumetinib | MEK | MAPK | 10753.146 | uM | inf | 1000.00000 | 0.7006 | 0.2461 | 0.1684 | 0.1412 | 0.9122 | 1.4503 | |
| HCC1187 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 10753.153 | uM | 3.79880 | 10.50580 | -0.9537 | -1.0000 | 1.0800 | 0.3248 | 0.9712 | 1.3879 | |
| HCC1187 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 10518.141 | uM | 4.60660 | 11.04240 | -0.9668 | -1.0000 | 1.2566 | 0.3372 | 0.9742 | 1.3122 | |
| HCC1187 | TNBC | Basal A | Sirolimus | MTOR | MTOR | 7433.069 | uM | 0.04230 | 0.00832 | 0.2153 | 0.3309 | 0.6665 | 0.4127 | 0.9409 | 1.0307 | |
| HCC1187 | TNBC | Basal A | Sirolimus | MTOR | MTOR | 7432.069 | uM | 0.00413 | 0.00589 | -0.2280 | -0.1078 | 0.5477 | 0.7176 | 0.9579 | 0.9727 | |
| HCC1187 | TNBC | Basal A | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7433.084 | uM | 241.76520 | 317.58380 | -0.9953 | -1.0000 | 4.0275 | 0.2467 | 0.8826 | 1.0291 | |
| HCC1187 | TNBC | Basal A | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7432.084 | uM | 26.63010 | 50.71840 | -0.7259 | -0.6599 | 1.3061 | 0.3357 | 0.9737 | 0.8538 | |
| HCC1187 | TNBC | Basal A | Sulindac sulfide | COX1/2 | COX | 10518.136 | uM | 927.95440 | 1000.00000 | 0.7851 | -0.0259 | 0.6766 | 0.0394 | 0.6183 | 1.2490 | |
| HCC1187 | TNBC | Basal A | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7432.067 | uM | 5.81250 | 7.2390 | -0.9992 | -0.9981 | 5.0000 | 0.4502 | 0.9970 | 1.0373 | |
| HCC1187 | TNBC | Basal A | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7433.067 | uM | 5.60790 | 8.32790 | -0.9958 | -1.0000 | 2.7782 | 0.4569 | 0.9972 | 1.0142 | |
| HCC1187 | TNBC | Basal A | Taxol | TUBB | TUBB | 7811.002 | uM | 0.00583 | 0.01049 | -0.9898 | -1.0000 | 1.8709 | 1.2966 | 0.9842 | 0.4929 | |
| HCC1187 | TNBC | Basal A | Taxol | TUBB | TUBB | 12696.002 | uM | 0.00802 | 0.00995 | -0.9713 | -0.9731 | 5.0000 | 1.2723 | 0.9944 | 0.7184 | |
| HCC1187 | TNBC | Basal A | Taxol | TUBB | TUBB | 9244.002 | uM | 0.00722 | 0.00898 | -0.9968 | -0.9950 | 5.0000 | 1.2989 | 0.9984 | 0.5206 | |
| HCC1187 | TNBC | Basal A | Taxol | TUBB | TUBB | 7812.002 | uM | 0.00801 | 0.00970 | -0.8107 | -0.8039 | 5.0000 | 1.1382 | 0.9988 | 1.0730 | |
| HCC1187 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 10753.152 | uM | 0.69805 | 1.0330 | -0.8418 | -0.8157 | 2.4684 | 0.5252 | 0.9937 | 1.3690 | |
| HCC1187 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 10518.14 | uM | 1.0160 | 1.24260 | -0.8690 | -0.8683 | 5.0000 | 0.4833 | 0.9979 | 1.2052 | |
| HCC1187 | TNBC | Basal A | TCS PIM-1 1 | Pim kinase | PIM | 10518.135 | uM | inf | inf | 0.4907 | 0.4907 | 0.0000 | 0.1417 | 0.0602 | 1.1446 | |
| HCC1187 | TNBC | Basal A | TCS PIM-1 1 | Pim kinase | PIM | 10753.148 | uM | inf | 19.54260 | 0.5317 | 0.5305 | 4.8194 | 0.0622 | 0.8397 | 1.2988 | |
| HCC1187 | TNBC | Basal A | Temsirolimus | MTOR | MTOR | 10753.144 | uM | 0.74356 | 10.51980 | -0.9855 | -1.0000 | 0.4146 | 0.5235 | 0.8233 | 1.3008 | |
| HCC1187 | TNBC | Basal A | Topotecan | TOP1 | TOP | 7812.047 | uM | 0.25717 | 0.30378 | -0.1021 | -0.2221 | 2.2065 | 0.5926 | 0.9292 | 1.0776 | |
| HCC1187 | TNBC | Basal A | Torkinib | 15300.211 | uM | 0.00035 | 0.03423 | -0.7443 | -1.0000 | 0.2401 | 1.0888 | 0.9649 | 0.8961 | |||
| HCC1187 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 10518.138 | uM | 0.09728 | 0.11455 | -0.5380 | -0.2289 | 2.3063 | 0.6356 | 0.9308 | 1.3413 | |
| HCC1187 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 10753.15 | uM | 0.09803 | 0.20848 | -0.5371 | -0.4359 | 0.8308 | 0.5754 | 0.9552 | 1.4129 | |
| HCC1187 | TNBC | Basal A | TPCA-1 | IKK | NFKB | 10518.1 | uM | 1.72660 | 4.80140 | -0.1947 | -0.4091 | 0.5845 | 0.4171 | 0.980 | 1.4056 |