Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1187 | TNBC | Basal A | TPCA-1 | IKK | NFKB | 7431.1 | uM | 2.92080 | 23.6230 | -0.3311 | -0.8931 | 0.4902 | 0.3710 | 0.9929 | 1.5594 | |
| HCC1187 | TNBC | Basal A | Trametinib | MEK | MAPK | 9244.012 | uM | inf | inf | 0.8051 | 0.8051 | 0.0000 | 0.0362 | 0.0762 | 0.4292 | |
| HCC1187 | TNBC | Basal A | Trametinib | MEK | MAPK | 7812.036 | uM | inf | inf | 0.9297 | 0.9297 | 0.0000 | 0.0087 | 0.2131 | 1.0103 | |
| HCC1187 | TNBC | Basal A | Trametinib | MEK | MAPK | 7811.036 | uM | 4.20720 | 17.31660 | 0.0126 | -1.0000 | 0.7765 | 0.1581 | 0.9649 | 0.4612 | |
| HCC1187 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 7433.065 | uM | 4.75510 | 5.90980 | -0.9877 | -0.9827 | 5.0000 | 1.0545 | 0.9988 | 0.8820 | |
| HCC1187 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 7431.065 | uM | 5.10640 | 7.86560 | -0.8862 | -0.8737 | 2.3395 | 0.9227 | 0.9989 | 1.4650 | |
| HCC1187 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 7432.065 | uM | 1.82480 | 2.79630 | -0.9944 | -0.9900 | 2.5582 | 1.1358 | 0.9990 | 0.7981 | |
| HCC1187 | TNBC | Basal A | Triciribine | AKT | AKT | 7431.074 | uM | 0.30781 | 0.32441 | -0.1484 | -0.1501 | 5.0000 | 0.4317 | 0.9260 | 1.4349 | |
| HCC1187 | TNBC | Basal A | Triciribine | AKT | AKT | 7432.074 | uM | 0.09985 | 0.94087 | -0.7596 | -1.0000 | 0.4898 | 0.5937 | 0.9931 | 0.8598 | |
| HCC1187 | TNBC | Basal A | U-0126 | MEK | MAPK | 7812.029 | uM | inf | inf | 0.1448 | 0.1448 | 0.0000 | 0.2281 | -0.0052 | 0.9642 | |
| HCC1187 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 10753.143 | uM | 703.9730 | 1000.00000 | -0.6533 | -0.3342 | 1.4581 | 0.2661 | 0.8781 | 1.4954 | |
| HCC1187 | TNBC | Basal A | Vinorelbine | TUBB | TUBB | 7812.042 | uM | 0.02448 | 0.02930 | -0.9783 | -0.7271 | 4.9992 | 1.0018 | 0.9513 | 0.9722 | |
| HCC1187 | TNBC | Basal A | Vinorelbine | TUBB | TUBB | 7811.018 | uM | 0.01088 | 0.01347 | -0.9977 | -0.9563 | 5.0000 | 1.2447 | 0.9982 | 0.4694 | |
| HCC1187 | TNBC | Basal A | Vorinostat | HDAC | HDAC | 7432.065 | uM | 19.95780 | 24.69860 | -0.9931 | -0.9513 | 5.0000 | 1.0060 | 0.9964 | 0.7981 | |
| HCC1187 | TNBC | Basal A | Vorinostat | HDAC | HDAC | 7433.065 | uM | 14.62480 | 30.19620 | -0.9857 | -0.9715 | 1.4889 | 0.9699 | 0.9978 | 0.8820 | |
| HCC1187 | TNBC | Basal A | Vorinostat | HDAC | HDAC | 7431.065 | uM | 35.18370 | 55.47640 | -0.8812 | -0.8647 | 2.2049 | 0.8325 | 0.9995 | 1.4650 | |
| HCC1187 | TNBC | Basal A | XRP44X | ELK3 | MAPK | 10518.139 | uM | 1.20340 | 1.41520 | -0.7378 | -0.6246 | 5.0000 | 0.5809 | 0.9830 | 1.2366 | |
| HCC1187 | TNBC | Basal A | XRP44X | ELK3 | MAPK | 10753.151 | uM | 0.53311 | 0.70192 | -0.8185 | -0.7226 | 3.2504 | 0.7265 | 0.9936 | 1.2139 | |
| HCC1187 | TNBC | Basal A | ZM-447439 | AURK | AURK | 10518.138 | uM | 0.23611 | 0.23002 | 0.0120 | 0.0612 | 5.0000 | 0.4780 | 0.9213 | 1.3413 | |
| HCC1187 | TNBC | Basal A | ZM-447439 | AURK | AURK | 10753.15 | uM | 0.49239 | 0.52921 | -0.1737 | -0.1339 | 3.2903 | 0.3927 | 0.9860 | 1.4129 | |
| HCC1395 | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 7814.016 | uM | 86.84590 | 1000.00000 | 0.3508 | -0.6755 | 0.3498 | 0.1708 | 0.7839 | 0.8623 | ||
| HCC1395 | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 7815.016 | uM | 47.30110 | 203.97620 | 0.0252 | -1.0000 | 0.7517 | 0.1275 | 0.9086 | 0.4370 | ||
| HCC1395 | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 7816.016 | uM | 39.77890 | 185.42730 | -0.0051 | -1.0000 | 0.7137 | 0.1857 | 0.9465 | 1.1183 | ||
| HCC1395 | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 7813.016 | uM | 38.11570 | 46.84880 | -0.8358 | -0.8400 | 4.7784 | 0.1276 | 0.9950 | 0.8531 | ||
| HCC1395 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 7813.037 | uM | 1.13960 | 2.30350 | -0.5356 | -0.4451 | 0.9048 | 0.3852 | 0.9661 | 0.7127 |