Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1395 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 9254.037 | uM | 0.19480 | 0.66652 | -0.5117 | -0.5396 | 0.5950 | 0.5855 | 0.9698 | 0.8345 | |
| HCC1395 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 7814.04 | uM | 0.08640 | 0.24294 | -0.6919 | -0.5378 | 0.7063 | 0.7010 | 0.9709 | 0.8711 | |
| HCC1395 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 9258.037 | uM | 0.09754 | 0.36203 | -0.8344 | -0.7213 | 0.6809 | 0.7182 | 0.9730 | 0.6992 | |
| HCC1395 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 7816.05 | uM | 0.16073 | 0.17234 | -0.2105 | -0.0721 | 1.9302 | 0.5052 | 0.9819 | 1.0200 | |
| HCC1395 | TNBC | Basal B | 5-DFUR | TYMS | TYMS | 12000.143 | uM | 84.36160 | 1000.00000 | -0.3079 | -0.7342 | 0.3654 | 0.3948 | 0.8405 | 0.8939 | |
| HCC1395 | TNBC | Basal B | 5-DFUR | TYMS | TYMS | 12084.143 | uM | 289.26680 | 1000.00000 | -0.1951 | -0.5512 | 0.5991 | 0.3095 | 0.9146 | 1.3499 | |
| HCC1395 | TNBC | Basal B | 5-FU | TYMS | TYMS | 7813.017 | uM | 796.13610 | 1000.00000 | -0.3296 | -0.2150 | 1.5689 | 0.2351 | 0.9750 | 0.8685 | |
| HCC1395 | TNBC | Basal B | 5-FU | TYMS | TYMS | 7816.017 | uM | 5569.35590 | 1000.00000 | 0.3951 | 0.3058 | 0.5506 | 0.1699 | 0.9805 | 1.2318 | |
| HCC1395 | TNBC | Basal B | 5-FU | TYMS | TYMS | 9258.03 | uM | 607.47860 | 1000.00000 | -0.8573 | -0.7154 | 1.7821 | 0.3361 | 0.9845 | 0.4015 | |
| HCC1395 | TNBC | Basal B | 5-FU | TYMS | TYMS | 7814.017 | uM | 306.00360 | 1000.00000 | -0.5095 | -0.6608 | 0.7113 | 0.3922 | 0.9860 | 0.8254 | |
| HCC1395 | TNBC | Basal B | Afatinib | EGFR/HER2 | ErbB | 12000.165 | uM | 1.06870 | 2.54330 | -0.9983 | -1.0000 | 1.2671 | 0.5583 | 0.9902 | 0.6978 | |
| HCC1395 | TNBC | Basal B | Afatinib | EGFR/HER2 | ErbB | 12084.158 | uM | 1.49040 | 3.26980 | -0.9851 | -1.0000 | 1.3984 | 0.4850 | 0.9943 | 1.2976 | |
| HCC1395 | TNBC | Basal B | AG1024 | IGF1R | RTK | 7435.066 | uM | inf | inf | 0.8858 | 0.8858 | 0.0000 | 0.0656 | -0.0232 | 0.8924 | |
| HCC1395 | TNBC | Basal B | AG1024 | IGF1R | RTK | 7436.066 | uM | inf | 4.570 | 0.5866 | 0.5741 | 1.8013 | 0.0928 | 0.8508 | 1.2738 | |
| HCC1395 | TNBC | Basal B | AG1478 | EGFR | ErbB | 7813.016 | uM | inf | inf | 0.8734 | 0.8734 | 0.0000 | 0.0271 | 0.1722 | 0.8531 | |
| HCC1395 | TNBC | Basal B | AG1478 | EGFR | ErbB | 7816.016 | uM | inf | inf | 0.4398 | 0.4398 | 0.0000 | 0.1476 | 0.3491 | 1.1183 | |
| HCC1395 | TNBC | Basal B | AG1478 | EGFR | ErbB | 7815.016 | uM | inf | inf | 0.2498 | 0.2498 | 0.0000 | 0.0580 | 0.3971 | 0.4370 | |
| HCC1395 | TNBC | Basal B | AG1478 | EGFR | ErbB | 7814.016 | uM | 22.10670 | 46.38880 | -0.7749 | -1.0000 | 1.4822 | 0.2711 | 0.9828 | 0.8623 | |
| HCC1395 | TNBC | Basal B | AS-252424 | PI3K | PI3K | 12084.158 | uM | 65.63810 | 363.1330 | 0.4863 | -1.0000 | 0.6422 | 0.0778 | 0.8932 | 1.2976 | |
| HCC1395 | TNBC | Basal B | AS-252424 | PI3K | PI3K | 12000.165 | uM | 105.32320 | 9.98050 | 0.5381 | 0.4952 | 1.9724 | 0.0455 | 0.8937 | 0.6978 | |
| HCC1395 | TNBC | Basal B | Baicalein | Lipoxygenase | Metabolism | 7436.073 | uM | 11.77990 | 9.54750 | 0.2809 | 0.2806 | 3.9209 | 0.1875 | 0.9718 | 1.2318 | |
| HCC1395 | TNBC | Basal B | Baicalein | Lipoxygenase | Metabolism | 7435.073 | uM | 20.17280 | 25.02740 | -0.1776 | -0.2231 | 1.7109 | 0.1764 | 0.9828 | 0.7153 | |
| HCC1395 | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 7435.074 | uM | 0.02593 | 0.04552 | -0.8969 | -0.9050 | 1.8359 | 1.2360 | 0.9935 | 0.8579 | |
| HCC1395 | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 7435.074 | uM | 0.02593 | 0.04552 | -0.8969 | -0.9050 | 1.8359 | 1.2360 | 0.9935 | 0.8579 | |
| HCC1395 | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 7436.074 | uM | 0.04608 | 0.07970 | -0.8305 | -0.8281 | 1.7831 | 1.1039 | 0.9977 | 1.2173 |